Protein Alignment CG34357 and gcy-23

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_500309.3
• Gene: gcy-23 / 191652
• WormBaseID: WBGene00001548
• Length: 1073
• Species: Caenorhabditis elegans
• Alignment Length: 1125
• Identity: 300/1125 - (26%)
• Similarity: 500/1125 - (44%)
• Gaps: 245/1125 - (21%)

  Fly   281 QFPAGEEESHSSGETEENHWNDARIFSG-HCHQLAEQLALDFNKTVVLWPCP---RMKISSNF-- 339
            |...||.....:...:..|....|.|.| :|:...:.:|    |....|..|   .|..|::|
 Worm    62 QMGCGESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVA----KMATFWNIPVVGYMASSNSFAD 122

  Fly   340 -----------LPSFEAISLAVQSISTKLNWSQVDIYIGDDNWGLGLAIAAN------------- 380
                       |.:..:::.|..::.....|::|             |||.|
 Worm   123 KTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKV-------------AIATNTGAVAFERVQSFE 174

  Fly   381 -------LHVPYRI------------------EIGRTIR-------DLHSQDKPGKAIIITAPLN 413
                   ::|..:|                  |:..:.|       .....:|.....:..:.:|
 Worm   175 EVFHQRGINVVRKIMLEEYTNAKAIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMN 239

  Fly   414 DASTILLLSTIELDWTEQARKDGQGSRPGRQHTKILLIDMAASS--LDTQHGF-------YKYLS 469
            :|:...:|..::|:..:.|...|:... .:|:.|    |..|:|  :|..:||       :|...
 Worm   240 NANYAWILPWLQLETKDMAPWLGENGE-YQQNVK----DHFANSFIIDDVNGFDNTLVTPFKERL 299

  Fly   470 RMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPS 534
            ...|..:|          ::...|:.....|.|..||:  |..:.|||..              :
 Worm   300 EASGYSTD----------DLEMKNIYGYIHLYDALRLY--ALAVRATMNE--------------T 338

  Fly   535 GHRNASLHKLYPYRNLLPL-YDTIVT-------TTTQSDTSETSPQFDFVVLDIVRDAPVATYKW 591
            |:.|:.|:....:.::..: :..:|:       |....|.:|.:|.:....:....|......:.
 Worm   339 GNENSYLNGKEVWNHMRRITFPGLVSNAGVTSGTVMMDDIAERAPVYAAFYVPPNSDTVRKVCEL 403

  Fly   592 RPLLILESDPGSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCG---AIC-WTIAAICVC 652
            .|:::...| |::.|....|...:.:|....|..|..|.....   .||   ..| :|...|..|
 Worm   404 EPVMLTNCD-GTKTGNGCYELQVTDLSTGFWPSIDGSLPADEP---ACGFRNEKCDYTTLIIGGC 464

  Fly   653 LLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEG-IEAMLCCWLQQLQ 716
            :::::|..|:.       :|:..|:.:  |:.:.:....::..|.|.:.|. :::||
 Worm   465 IVLLIILLIIC-------FFILSRVCE--NRALANTPWRIYRDDFRTIQENEMKSML-------- 512

  Fly   717 EFGGPEVDKPDLLKGSIGSLK----NLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPA 777
                           ||||.|    |:...:...|..|     |.|               |...
 Worm   513 ---------------SIGSSKTKMSNMSMFVKHHAVVG-----TNT---------------HASF 542

  Fly   778 HLDMRAR---YNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGW-LSDPNRTAMV 838
            ||..:.|   :|...:||                 |..|...: |:|:||.:|. .::.....::
 Worm   543 HLYPQRRPIVFNRQDLQL-----------------LNQMKQAV-HDNLNPFLGMSFNEKEEMVVL 589

  Fly   839 FDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKI 903
            :.:||||::||::...|:.||..|..:.:.|:..|:.|||:|.:..||:||..:|::|..|::|:
 Worm   590 WKFCSRGTIQDMIYNQEVSLDSKFHGAFIRDITLGLEYLHSSIIGYHGSLTPWSCLIDRNWMIKL 654

  Fly   904 TDYGLNS---FYESQGLPPRTRSAKE------------LLWTAPELLRNMKLHQHHHQH----GR 949
            ||||:.:   .:|..|| ..|.:.||            ||:..||:|:|.:.::.....    .:
 Worm   655 TDYGIANPLERWEKLGL-ISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWVKQ 718

  Fly   950 IQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSV-SKGAAPPEAINI 1013
            .|...|:||:|:||::|.|::.|..|: ....:..|::..|:......||:| .:....|:.:.:
 Worm   719 SQARRQMGDIYAFGMVMHEILFRALPF-PNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVAL 782

  Fly  1014 MRQCWAEQPDMRPDFNSVYERFKMLNHGR-KVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERK 1077
            :..||.|.|::||....|  |....|:.: |.:.||.|.:|:|:|:||||:|:.|||..|:....
 Worm   783 LLDCWNENPEVRPSIRRV--RLNTENYLKVKGSLVDQMMRMMEQYANNLEKLVAERTGMLEEANV 845

  Fly  1078 KTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIF 1142
            :.::||.::||..||.:||||.:|..:.|...|:.||||||||||.:..:|::||.:||.:|:.|
 Worm   846 RADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKF 910

  Fly  1143 DATINAYNVYKVETIGDAYMVVSGLPVKI-PDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRI 1206
            |..||.:..|||||||||||:|||:|.:. .:|...|...||:|:.....:.:.|...|.|::|:
 Worm   911 DDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVKLRIRL 975

  Fly  1207 GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRD---RLDARGGYAIEPR 1268
            |:|||...|||||||.|||||||||||.|||||||....:|.||||.||   |..:.  :.|..|
 Worm   976 GIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSE--FQITLR 1038

  Fly  1269 GLIDIKGKGMMNTFWLLGKK 1288
            |.::.||||.:.::|||||:
 Worm  1039 GTVEAKGKGPVTSYWLLGKQ 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	80/301 (27%)
		CYCc	1074..1266	CDD:214485	94/195 (48%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	64/392 (16%)
		ANF_receptor	38..385	CDD:279440	62/370 (17%)
		PK_GC	509..806	CDD:270894	91/361 (25%)
		HNOBA	<817..863	CDD:285003	19/45 (42%)
		CYCc	842..1035	CDD:214485	94/194 (48%)
		Guanylate_cyc	869..1056	CDD:278633	93/188 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810