Protein Alignment CG34357 and gcy-19

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001348702.1
• Gene: gcy-19 / 191650
• WormBaseID: WBGene00001544
• Length: 1187
• Species: Caenorhabditis elegans
• Alignment Length: 1329
• Identity: 364/1329 - (27%)
• Similarity: 539/1329 - (40%)
• Gaps: 369/1329 - (27%)

  Fly   199 NVTVDFLRDVDLSGFIKLLELP---KYTSVIKTLNAGI----MVASHVDVDQNSTIYIGTPSQPR 256
            |:.:..|||   .|||...:..   .||...::|.|.:    |....:||      .||.|.
 Worm    69 NMAIQKLRD---DGFIAPFDFEVTVNYTECDRSLGAAVGMEFMRTKRLDV------VIGPPC--- 121

  Fly   257 QQHRLHSKQEQEPHRHHHEDSKAKQFPAGEEESHSS-----GETEENHWNDARIFSGHCHQLAEQ 316
                      ::|          .:..|.....:|:     |...::.:.|...:....:.:|..
 Worm   122 ----------RDP----------MEIMATMATYYSTPMLGWGLVTDSKFTDTERYPYLTNIMANS 166

  Fly   317 LALDFNKTVVLWPCPRMKISSNFLPSFEAISLAV-QSISTKLNWSQVDIYI-----------GDD 369
            |:|.|:...:|......:::..:..|.:...|:| ..:.|.:|  :.|.:.           ||.
 Worm   167 LSLGFSLVKLLEMMEWDRVALVYEESAQDYPLSVINDVETAIN--EYDTFAVNVVVKQALPGGDL 229

  Fly   370 NWGLGLAIAANLHVPYRI--EIGRTI----RDLHSQDKPGKA------III----------TAPL 412
            |....:::...:.:..||  .:.:|.    |.|...|:.|.|      |::          :|.|
 Worm   230 NDAQYISVLNRIKLRCRIIVSVFQTAPTRRRYLKMIDQQGMANEEYVHILLGLRSIGFGKQSAGL 294

  Fly   413 NDASTILLLSTIELDWTEQARKDGQGSRPGRQHTKILLIDMA-ASSLDTQHGFYKYLSRMGGSQS 476
            .......|.|.:...| :.|..||...|..:..|::|::|:. ...|.|......||
 Worm   295 TKCELNCLSSGLAPFW-DIAPDDGLNDRLKQAATRMLVMDLPDTMDLSTDVPDINYL-------- 350

  Fly   477 DAFARNTG--------------------SPAEVVSSNL--------LVLT--------LLNDRHR 505
            :.|..|.|                    ||....:.:|        |.:|        .|||..:
 Worm   351 NTFTMNCGAVVVNPPVSCATPACINASTSPPSAFARSLHDVFYLYGLAITNLYNQDPAYLNDIDK 415

  Fly   506 ----LFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTTTQSDT 566
                |.||.|||...:.     :|.|          |:.:.||..|. |...||
 Worm   416 INGALQLNFAGLTGEVS-----INAN----------NSRVPKLMLYA-LNDKYD----------- 453

  Fly   567 SETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVE-------------GGGSYIS 618
                 |..|:.|         ||             |..||:.|.             ||...:|
 Worm   454 -----QASFMNL---------TY-------------SLNGGASVSLAYTNEASLWYWYGGKRPLS 491

  Fly   619 HSI--HPGYDEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVAGGIAMRNYFLR-KRLSKG 680
            ..:  ..|.|    .....:.|.||:.:.|..:.:..::.:|....        |.:| |||.:.
 Worm   492 VPVCGFAGTD----CPQSFVDQYGALVFAIGGVLIFAMLFVITCFF--------YVMRQKRLERD 544

  Fly   681 PNKIVLSASDFVFPVDSRRVDEGIEAMLCCW---LQQLQEFGGPEVDKPDLLKGSIGSLKNLGFV 742
                              |:|..       |   |.:||  ..|:.||..:.|.|:.|
 Worm   545 ------------------RIDAE-------WQIPLVKLQ--APPKRDKERMSKRSLQS------- 575

  Fly   743 IPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNIN----GSAEL 803
                 .|.:   ||.|    |..:...:.:.::..:||            ||..::    .|..:
 Worm   576 -----GPSN---ITDT----SKMTFDNTFSNYSIFYLD------------KEPVLSTAHPASNLI 616

  Fly   804 RTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLT 868
            ||. .|..|....|.|||:|..:|...|......|:..|.||||||::......:|..|...::.
 Worm   617 RTD-YDTFVRLRKLDHENVNKFVGMSIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIR 680

  Fly   869 DLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPE 933
            |:..|::|||.|.|.||..|.|...:|:..|..|:||:||.:..|.: .|.:.|.    ||.|||
 Worm   681 DMAEGLKYLHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEK-KPMKRRQ----LWMAPE 740

  Fly   934 LLRNMKL-HQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSL--SPEEIIVKIKKPPP 995
            ::|...| ||..          :..|:||..:|..||:.|.|.:.|...  :.:||:.:|||..|
 Worm   741 VIRGTLLPHQIE----------KSADIYSLAVIASEVLTRKEAWNMAERKDTVDEIVYRIKKGGP 795

  Fly   996 LIRPSVSKGAAPPE------AIN-----IMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDT 1049
                    .|..||      .||     ::|.||:|:|..||..:.:....|.: ..:|.|.:|.
 Worm   796 --------NAPRPELDMDGVEINHNLLILIRDCWSEEPADRPSADVICNLLKNM-MPKKGNLMDH 851

  Fly  1050 MFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFS 1114
            :|.:||.|:.|||..:.:||::|..|:||.:.||.||||..|||:||.|..|:||.|..||::||
 Worm   852 VFNILEDYTTNLEVEVEDRTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFS 916

  Fly  1115 DIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQI 1178
            |:|.||.:||.|||.|||:||||||:.|||.|..:..||||:|||.|:.|||||.|..: |.:||
 Worm   917 DVVKFTQLAAKCSPFQVVNLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQI 981

  Fly  1179 ATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGS 1243
            ..::||.:.....|.:.|||...::||||:::|||.||||||:|||||||||||||||||||.|.
 Worm   982 VELSLDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGK 1046

  Fly  1244 SWRIHMSQETRDRLDAR--GGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGL 1306
            :..||:|..:...|...  ..|....||.:.|||||:|.|||:     |:
 Worm  1047 ASHIHLSAASYTLLMKHYPNQYNTASRGDVIIKGKGVMETFWV-----FE--------------- 1091

  Fly  1307 DESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDS 1371
                 ||:..:...:|....|...:::..||         .|.|||:.         |..:.:.:
 Worm  1092 -----RNNQFMGVSSNSGYQSDKKATNNGSS---------PESTPPST---------PPMHEVKA 1133

  Fly  1372 NSTNTISPNATLCPEFPGKTTPS--STSP 1398
            |     ||.....|..|...|.|  |.||
 Worm  1134 N-----SPVRHRKPPSPSSPTLSKRSVSP 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	85/295 (29%)
		CYCc	1074..1266	CDD:214485	106/194 (55%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	93/494 (19%)
		PKc_like	571..841	CDD:328722	91/324 (28%)
		CYCc	876..1065	CDD:214485	105/188 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770