Protein Alignment CG34357 and gcy-14

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_506660.2
• Gene: gcy-14 / 191647
• WormBaseID: WBGene00001540
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1263
• Identity: 351/1263 - (27%)
• Similarity: 516/1263 - (40%)
• Gaps: 365/1263 - (28%)

  Fly   288 ESHSSGETEE--NHWNDARIFSGHCHQ---LAEQLALDFNKTVVLW---------PCPRMKISSN 338
            |..:.|:|.|  ||.|...|....|::   ....||..:|..|..|         ...|...:..
 Worm    75 EGLAGGKTVELINHDNVDVIIGPTCNRAGIAVASLAAYYNVPVFQWGLTTAADIGNVSRYPTTVT 139

  Fly   339 FLPSFEAISLAVQSISTKLNWSQ-VDIY-----------IGDDNWGLGLAIAANLHVPYRIEIGR 391
            ......:::|.|:.:..:..|.: |.||           :.||...:|:. .:::.:.|.::|..
 Worm   140 LSLDTHSMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMGIE-NSDVTLAYMVQIQT 203

  Fly   392 TIRD-----LHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQARKDGQGSRPGRQHTKILLI 451
            ...|     |....|.|: |||....|                            ||...|..:.
 Worm   204 VTLDALQKALTEVSKRGR-IIIACFAN----------------------------GRGFKKAFVA 239

  Fly   452 DMAASSLDTQHGFYK---------YLSRMGGSQSDAFARNTG------SPAEVVSSNLLVLTLLN 501
            ....:.:.|....|.         |:..:.|.:..::....|      :|.::..:...||.:.:
 Worm   240 STVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQIRDAYGKVLYICD 304

  Fly   502 DRHRLFLNAAGLMATM----QNFRAPL----------------NGNYKDPPPSGHRNASLHKLYP 546
            :        .||..|:    .||.:.|                |..||  .|:.:........|.
 Worm   305 N--------MGLPTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYK--VPATYAGQLFDAFYA 359

  Fly   547 Y-----RNLLPLYDTIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGG 606
            |     |:|           ||..|........||:.||..                |..|..||
 Worm   360 YGVALNRSL-----------TQDPTRANLKNGSFVLSDIGM----------------SFQGVGGG 397

  Fly   607 GSVVEGGGSYI--------SHSIHPGYDEWLLVSSVL----------------LWQ--------C 639
            ...::..|:.|        :.|:.|    :|..|.|:                ||.        |
 Worm   398 TVTLDDTGTRIVQVYMFALNTSLLP----YLAASLVINGSEVEYTPFYKSEADLWSVRPLARPIC 458

  Fly   640 G-------------AICWTIAAICVCLLVIMIAGIVAG--GIAMRNYFLRKRLSKGPNKIVLSAS 689
            |             .:.:||.|     .||::..::||  |:.......||.:.:         .
 Worm   459 GFSGLECPPDFVKEYLVYTIIA-----AVIVVLALLAGCAGLLYTMQMKRKEMER---------Q 509

  Fly   690 DFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGA 754
            |.::.|..      ||      |||:|.....|        .|:.|.         |:.|.::..
 Worm   510 DLLWQVPF------IE------LQQVQSKSKAE--------ASMHSF---------ASGPSTSTK 545

  Fly   755 ITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRH 819
            ||.    :|.|.....:..:  ...|:.|....||:  .:.:....||.|        ......:
 Worm   546 ITV----ESRSETINFIFYY--YQQDILAAMKHDLI--LQFDAEQKAEFR--------QMRNFDN 594

  Fly   820 ENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRV 884
            :|:|..||...|..:...::.:||||||.||:....:::|..|..||:.|:..|:.::|.|.|:.
 Worm   595 DNLNKFIGLCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKC 659

  Fly   885 HGALTSRNCVVDARWVLKITDYGLNSF--YESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQH 947
            ||.||||.|::|.||.:||:.|||.|.  :|:    |:   .::||||.||.|||       ...
 Worm   660 HGHLTSRCCLIDDRWQIKISGYGLKSVRTFEN----PK---KEDLLWTPPENLRN-------ENE 710

  Fly   948 GRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSL--SPEEIIVKIKK----PPPLIRPSVSKGAA 1006
            .|:    ..||:||||||..|::.|...:.:.:.  .|:.||.::||    |   :|||:..|..
 Worm   711 ERL----PEGDIYSFGIICSEILTRSSAFDLENRKEKPDVIIYQVKKGGHNP---MRPSLDTGET 768

  Fly  1007 ---PPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRER 1068
               .|..::::|.||.|:|..||....|......:..|||.|.:|.:|.|||.|::.|||.:.:|
 Worm   769 VEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDR 833

  Fly  1069 TEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVD 1133
            |::|..|:||::.||.||||..||:|||:|..|:||.|..|||:|||:|.|||:|..|:|:|||.
 Worm   834 TKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVT 898

  Fly  1134 LLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKI-PDHAEQIATMALDLLHQSGRFNVKHL 1197
            ||||||||||..|...:|||||||||.|:.|||||.:. .:|...||.|:|..|.....|.|:||
 Worm   899 LLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHL 963

  Fly  1198 PGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRL-DARG 1261
            |...:.||||::.|...||||||||||||||||.|||||||||.|...:||::.|....| ...|
 Worm   964 PSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVG 1028

  Fly  1262 GYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRT 1326
            |:..|.||.:.|||||:|.|:||||:                        ::.|::.|||.:.:|
 Worm  1029 GFRTESRGEVIIKGKGVMETYWLLGE------------------------QSRISVSAQAPREKT 1069

  Fly  1327 STNPSSSQSSSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKT 1391
                                                                      ||.|.:.
 Worm  1070 ----------------------------------------------------------PEPPRRQ 1076

  Fly  1392 TPSSTSPQSRKLSELTPENLLNP-NSFN 1418
            :..|.||...|:||.|.:.|.:. ..||
 Worm  1077 SVRSISPIIEKMSEETQKGLYSAYKDFN 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	88/288 (31%)
		CYCc	1074..1266	CDD:214485	109/193 (56%)
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347	74/418 (18%)
		ANF_receptor	43..418	CDD:279440	72/409 (18%)
		PKc_like	535..800	CDD:304357	93/310 (30%)
		HNOBA	<817..860	CDD:285003	21/42 (50%)
		CYCc	839..1031	CDD:214485	109/191 (57%)
		Guanylate_cyc	866..1053	CDD:278633	106/186 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770