DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gcy-13

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	1069	Identity:	331/1069 - (30%)
Similarity:	485/1069 - (45%)	Gaps:	218/1069 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LALDFNKTVVLWPCPRMKISSNFL------------PSFEAISLAVQSISTKLNWSQ-VDIYIGD 368
            ||..:|..|:.|   .:.|||:|:            |..::|:.|:..:..:..|:: |.:::.|
Worm    77 LAGYYNTPVLTW---GLTISSSFIDTSKYPTTVTIVPVAKSIAAAIHEVMIQFEWTEFVYVFVED 138

  Fly   369 DNWGLGLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQAR 433
            :..|.                   .||...|        ||:..|..|....:...:..:|...|
Worm   139 EKCGY-------------------FRDDLEQ--------ITSDSNYTSLSRTIQIYDQSYTNLVR 176

  Fly   434 KDGQGSRPGRQHTKIL--------LIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVV 490
            :..:.....|..|..|        ...:||..||.....|.||  ..|.:|.|: :.|.|..:||
Worm   177 QLEKLKTVSRIFTVCLPEAGDIKRRFMLAAYDLDMTTDEYVYL--FAGPKSTAY-QQTSSTGDVV 238

  Fly   491 SSNLLVLTLLNDRHR------LFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRN 549
              .:.|....|...|      .|:....::||               |..|.:.|:..|....|.
Worm   239 --GIWVDWSENPDGRDEEAKLAFMRTMVIVAT---------------PVQGEQYAAFKKEVIERM 286

  Fly   550 LLPLYDTIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILE--------------SD 600
            .||.|:.:      .:..|...|......|.:.|. :..|    .|||.              |:
Worm   287 KLPPYNCV------DECKEKEYQEAAEYADQLHDT-IYLY----ALILNKTIEEQGIEQIANGSN 340

  Fly   601 PGSRGGGSVVEG-GGSYISHSIHPGYD------------------EWLLVSSVLLWQCGAICWTI 646
            ..:||.|...|| .|....:.|  ||.                  .::.:.|.      ::.||.
Worm   341 IVTRGAGIEFEGMSGVVRMNGI--GYRLPNMNLANLDSNATQRTVAYMDIDST------SVNWTF 397

  Fly   647 AAICVCLLVIMIAGIV---------AGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDE 702
            |.|...|:.....|.:         :|.....|:|:                |:::.|    |..
Worm   398 AIIDQALIWDAYNGKLPQTRPECGYSGKSCPVNFFV----------------DYLYIV----VIV 442

  Fly   703 GIEAMLCCWLQQLQEFGGPEVDKPDLLK---------GSIGSLKNLGFVIPGAA----APGSAGA 754
            .:..:|||....:..|...:..:.:.|:         |.:.|      :|.|..    :..|..:
Worm   443 AVIIVLCCAAAAIAAFLVIKARRDEELRLDDQWIVPHGMLQS------IIKGRKESHHSSRSLQS 501

  Fly   755 ITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRT----KAMDLLVMAH 815
            .:||..|.:|.|:..........        .|..|.:.|..:....:||.    :....|.|..
Worm   502 NSTTTTGTTGISSRSVFFPETET--------QGYFVYMNEPVLARKYQLRVPIFKQDRSELRMLR 558

  Fly   816 GLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTS 880
            .:.|:|:|..||...|.......:.||||||::||:....|.:|..|...|:.|:..|::|:|.|
Worm   559 SIEHDNVNRFIGLSIDGPVYMSFWRYCSRGSIKDVIAKSSINMDGFFIYCLIKDIASGLQYIHHS 623

  Fly   881 PLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHH 945
            |::.||:|||..|.::.||.:||..||| ||  .||:..||...  ||.||||:||.
Worm   624 PIKQHGSLTSECCYINDRWQVKIGSYGL-SF--MQGVEKRTEDG--LLHTAPEVLRE-------- 675

  Fly   946 QHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPE--EIIVKIK---KPPPLIRPSVS--K 1003
               .:..|||.||||||.|:..|:|.....:.:.:...|  |||..:|   :.|  .|||:.  .
Worm   676 ---GLTSGTQAGDVYSFSIVCSELVGHSSAWNLENRKEEADEIIFMVKRGGRTP--FRPSLDDVD 735

  Fly  1004 GAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGR--KVNFVDTMFQMLEKYSNNLEELIR 1066
            ....|..::::|.||.|.|..||:.:.|.:..|.:|.||  ..|.:|.:|.:|||::::||:.::
Worm   736 DDINPAMLHLIRDCWDEDPKQRPNIDMVNKLMKNMNSGRSGSANLMDHVFSVLEKHASSLEDEVQ 800

  Fly  1067 ERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQV 1131
            ||.::|..|:||::.||.||||..|||:||:|.:|:||.|..|||:|||:||||.:|...:|:||
Worm   801 ERMKELVEEKKKSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFTVLANKSTPLQV 865

  Fly  1132 VDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKI-PDHAEQIATMALDLLHQSGRFNVK 1195
            |:|||||||.|||.|...:.||||||||||:||||||.:. .:|...||.|:|:|:.....|.:.
Worm   866 VNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFKIP 930

  Fly  1196 HLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA- 1259
            |||...:|:|||:|:|.|.||||||||||||||||||||||||||.|....||:|.:..|.|.:
Worm   931 HLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLTSL 995

  Fly  1260 RGGYAIEPRGLIDIKGKGMMNTFWLLGKK 1288
            ...|..|.||.:.|||||:|.|:||||.|
Worm   996 YKEYNTESRGEVIIKGKGVMQTYWLLGMK 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	92/288 (32%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	111/193 (58%)
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347	76/388 (20%)
		ANF_receptor	13..368	CDD:279440	74/353 (21%)
		PKc_like	548..770	CDD:304357	84/239 (35%)
		HNOBA	<797..829	CDD:285003	15/31 (48%)
		CYCc	808..1000	CDD:214485	110/191 (58%)
		Guanylate_cyc	835..1022	CDD:278633	108/186 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770