DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gcy-5

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	958	Identity:	294/958 - (30%)
Similarity:	434/958 - (45%)	Gaps:	200/958 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 DGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSR--------------------MGGSQSDAF 479
            ||..:...|...|:|:||:.:...|.:  |.:||::                    ...:...::
Worm   297 DGNETNARRAAEKMLVIDVNSDVQDAE--FLQYLTKNIADAVRNPPMKCNTSECINASSTSMGSY 359

  Fly   480 AR----------------NTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQN-FRAPLNGN 527
            ||                |:..|....:.|||:..::..    |....|.:...|| :|.|
Worm   360 ARHLFDVFYLYGMAVSKLNSTDPTVYGNLNLLMPQMVTS----FDGMTGRVQIGQNLYRVP---- 416

  Fly   528 YKDPPPSGHRNASLHKLYPYRNLLPLYD--TIVTTTTQSDTSETSPQFD------FVVLDIVR-- 582
                         .::||   .|...|:  .:|..|..:.:|:.|..:.      :...|..|
Worm   417 -------------TYQLY---GLDEKYEQVALVNMTFYNSSSQLSRGYSDEGRSVWHFWDGTRPL 465

  Fly   583 DAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAICWTIA 647
            |.|:..:                       .|.|........|...:.|:|::|         |.
Worm   466 DTPICGF-----------------------SGRYCPVQFWDQYGVLIFVASIVL---------IF 498

  Fly   648 AICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWL 712
            .||:.|:.                                   |.|.:..||.::  |.:...|
Worm   499 LICIMLMC-----------------------------------FGFMIRGRRAEQ--ERLNSEW- 525

  Fly   713 QQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPA 777
                :....::..|...|....|.::|           .:|..|.|  |:|..:..|..  |...
Worm   526 ----QIPSIQLIMPQKEKRKPNSRRSL-----------QSGPSTIT--GESKMTIDGGF--HENY 571

  Fly   778 HLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYC 842
            .:.|   :..|||...:   :.|.::..:..:..|....|.|:|:|..||...|..:...|:..|
Worm   572 TVQM---FEKDLVLTTK---HHSMQMNKEEKEKFVKLRKLEHDNLNKFIGLSIDGPQFVAVWKMC 630

  Fly   843 SRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYG 907
            |||||||::......:|..|...::||:..||.:||.|.|.:||.|.|..|:|:..|.:|:||:|
Worm   631 SRGSLQDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSFLHLHGNLRSATCLVNDSWQVKLTDFG 695

  Fly   908 LNSFYESQGLPPRTRSAKELLWTAPELLR-NMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVV 971
            |.:..|.     .|.|.|.|||.|||:|| ::.:||....          .|||||.||..|::.
Worm   696 LGALLEE-----HTPSKKRLLWAAPEVLRGSLTIHQMDPS----------ADVYSFAIIASEILT 745

  Fly   972 RGEPYCMLSL--SPEEIIVKIKK-PPPLIRPSVSKGA-APPEAINIMRQCWAEQPDMRPDFNSVY 1032
            :.|.:.:.:.  ..:||:..:|| ....|||.:...| ..|....:::.||:|||:.||....:.
Worm   746 KREAWDISNRKEGADEILYMVKKGGNRTIRPELILDAEVSPRLTTLVKDCWSEQPEDRPKAEQIC 810

  Fly  1033 ERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKM 1097
            :....:......|.:|.:|.|||:|::.||..|.|||::|.:|:||.:.||:||||..|||:||.
Worm   811 KLLSEMTPRGNTNLMDHVFNMLEEYTSTLEVDIEERTKELTLEKKKADILLSRMLPKQVAERLKA 875

  Fly  1098 GLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYM 1162
            |..|:||.|..||:.|||:|.||.:||.|||.|||:||||||:.||..|..:.|||||:|||.|:
Worm   876 GQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTIIEEHGVYKVESIGDGYL 940

  Fly  1163 VVSGLPVKIP-DHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYC 1226
            .|||||.|.. .|.:||..|:|..:.....|.|.|||...::||||:::|||.||||||:|||||
Worm   941 CVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGINSGPCVAGVVGLSMPRYC 1005

  Fly  1227 LFGDTVNTASRMESTGSSWRIHMSQETRDRLDAR--GGYAIEPRGLIDIKGKGMMNTFWLLGKKG 1289
            ||||||||||||||.|....||||:.....|...  ..|....||.:.|||||:|.|||:|||..
Worm  1006 LFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVIIKGKGVMETFWVLGKTD 1070

  Fly  1290 FD-KPLP--APPPIGESH---GLDESLIRNSIT---LKAQANKSRTST 1328
            .| |.|.  ..|||.:.:   .:.|.|.:.::|   .:.::.||:..|
Worm  1071 SDTKSLSTRTTPPITDENWPPQMKEDLKKRAVTPYPERQRSGKSKMDT 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	86/282 (30%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	108/194 (56%)
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347	30/168 (18%)
		ANF_receptor	49..426	CDD:279440	27/154 (18%)
		PK_GC	546..816	CDD:270894	91/305 (30%)
		HNOBA	<830..873	CDD:285003	23/42 (55%)
		CYCc	852..1042	CDD:214485	107/189 (57%)
		Guanylate_cyc	879..1067	CDD:278633	104/187 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770