Protein Alignment CG34357 and gcy-5

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_496219.1
• Gene: gcy-5 / 191643
• WormBaseID: WBGene00001532
• Length: 1122
• Species: Caenorhabditis elegans
• Alignment Length: 958
• Identity: 294/958 - (30%)
• Similarity: 434/958 - (45%)
• Gaps: 200/958 - (20%)

  Fly   435 DGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSR--------------------MGGSQSDAF 479
            ||..:...|...|:|:||:.:...|.:  |.:||::                    ...:...::
 Worm   297 DGNETNARRAAEKMLVIDVNSDVQDAE--FLQYLTKNIADAVRNPPMKCNTSECINASSTSMGSY 359

  Fly   480 AR----------------NTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQN-FRAPLNGN 527
            ||                |:..|....:.|||:..::..    |....|.:...|| :|.|
 Worm   360 ARHLFDVFYLYGMAVSKLNSTDPTVYGNLNLLMPQMVTS----FDGMTGRVQIGQNLYRVP---- 416

  Fly   528 YKDPPPSGHRNASLHKLYPYRNLLPLYD--TIVTTTTQSDTSETSPQFD------FVVLDIVR-- 582
                         .::||   .|...|:  .:|..|..:.:|:.|..:.      :...|..|
 Worm   417 -------------TYQLY---GLDEKYEQVALVNMTFYNSSSQLSRGYSDEGRSVWHFWDGTRPL 465

  Fly   583 DAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAICWTIA 647
            |.|:..:                       .|.|........|...:.|:|::|         |.
 Worm   466 DTPICGF-----------------------SGRYCPVQFWDQYGVLIFVASIVL---------IF 498

  Fly   648 AICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWL 712
            .||:.|:.                                   |.|.:..||.::  |.:...|
 Worm   499 LICIMLMC-----------------------------------FGFMIRGRRAEQ--ERLNSEW- 525

  Fly   713 QQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPA 777
                :....::..|...|....|.::|           .:|..|.|  |:|..:..|..  |...
 Worm   526 ----QIPSIQLIMPQKEKRKPNSRRSL-----------QSGPSTIT--GESKMTIDGGF--HENY 571

  Fly   778 HLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYC 842
            .:.|   :..|||...:   :.|.::..:..:..|....|.|:|:|..||...|..:...|:..|
 Worm   572 TVQM---FEKDLVLTTK---HHSMQMNKEEKEKFVKLRKLEHDNLNKFIGLSIDGPQFVAVWKMC 630

  Fly   843 SRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYG 907
            |||||||::......:|..|...::||:..||.:||.|.|.:||.|.|..|:|:..|.:|:||:|
 Worm   631 SRGSLQDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSFLHLHGNLRSATCLVNDSWQVKLTDFG 695

  Fly   908 LNSFYESQGLPPRTRSAKELLWTAPELLR-NMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVV 971
            |.:..|.     .|.|.|.|||.|||:|| ::.:||....          .|||||.||..|::.
 Worm   696 LGALLEE-----HTPSKKRLLWAAPEVLRGSLTIHQMDPS----------ADVYSFAIIASEILT 745

  Fly   972 RGEPYCMLSL--SPEEIIVKIKK-PPPLIRPSVSKGA-APPEAINIMRQCWAEQPDMRPDFNSVY 1032
            :.|.:.:.:.  ..:||:..:|| ....|||.:...| ..|....:::.||:|||:.||....:.
 Worm   746 KREAWDISNRKEGADEILYMVKKGGNRTIRPELILDAEVSPRLTTLVKDCWSEQPEDRPKAEQIC 810

  Fly  1033 ERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKM 1097
            :....:......|.:|.:|.|||:|::.||..|.|||::|.:|:||.:.||:||||..|||:||.
 Worm   811 KLLSEMTPRGNTNLMDHVFNMLEEYTSTLEVDIEERTKELTLEKKKADILLSRMLPKQVAERLKA 875

  Fly  1098 GLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYM 1162
            |..|:||.|..||:.|||:|.||.:||.|||.|||:||||||:.||..|..:.|||||:|||.|:
 Worm   876 GQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTIIEEHGVYKVESIGDGYL 940

  Fly  1163 VVSGLPVKIP-DHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYC 1226
            .|||||.|.. .|.:||..|:|..:.....|.|.|||...::||||:::|||.||||||:|||||
 Worm   941 CVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGINSGPCVAGVVGLSMPRYC 1005

  Fly  1227 LFGDTVNTASRMESTGSSWRIHMSQETRDRLDAR--GGYAIEPRGLIDIKGKGMMNTFWLLGKKG 1289
            ||||||||||||||.|....||||:.....|...  ..|....||.:.|||||:|.|||:|||..
 Worm  1006 LFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVIIKGKGVMETFWVLGKTD 1070

  Fly  1290 FD-KPLP--APPPIGESH---GLDESLIRNSIT---LKAQANKSRTST 1328
            .| |.|.  ..|||.:.:   .:.|.|.:.::|   .:.::.||:..|
 Worm  1071 SDTKSLSTRTTPPITDENWPPQMKEDLKKRAVTPYPERQRSGKSKMDT 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	86/282 (30%)
		HNOBA	<1047..1095	CDD:462234	25/47 (53%)
		CYCc	1074..1266	CDD:214485	108/194 (56%)
gcy-5	NP_496219.1	PBP1_NPR_GC-like	30..439	CDD:380575	30/167 (18%)
		PK_GC	546..816	CDD:270894	91/305 (30%)
		HNOBA	<829..873	CDD:462234	24/43 (56%)
		CYCc	852..1042	CDD:214485	107/189 (57%)