Protein Alignment CG34357 and daf-11

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_505960.3
• Gene: daf-11 / 179605
• WormBaseID: WBGene00000907
• Length: 1077
• Species: Caenorhabditis elegans
• Alignment Length: 1249
• Identity: 300/1249 - (24%)
• Similarity: 481/1249 - (38%)
• Gaps: 373/1249 - (29%)

  Fly   336 SSNFLPSFEAISLAVQSISTKL---------------------------------NWSQV----- 362
            ||||| .|..::..:||:...:                                 .|.||
 Worm     6 SSNFL-RFANLTAEMQSLEINILKGYPYEHPTMIDMVTRSPQNLAQNLVSLLRGFEWGQVGAVLC 69

  Fly   363 -DIYIGDDNWGLGLAIAA--------------NLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPL 412
             :.|.||:       :|:              |:.:...:.||:....::..|    ||.|..|
 Worm    70 EECYEGDE-------LASEIYFSTIEDIFENNNIALKETVRIGKRENSVNISD----AITIFEP- 122

  Fly   413 NDASTILLLSTIEL-DWTEQARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQS 476
             .|..|||....:| |:||........:....::|.:::|  :.:||:....:         .::
 Worm   123 -SARVILLFLGNKLNDYTEFMTAMSMNNYTTEEYTPVIVI--SKNSLELTFPW---------KEN 175

  Fly   477 DAFARNTGSPAEVVSSNLLVLTLLNDRHRL--FLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNA 539
            ||.       ||:....::|.....|:.::  ||::.. .:|::.....|
 Worm   176 DAI-------AELFDKAIIVYNNCYDKSKISSFLSSYS-FSTIEETIISL--------------- 217

  Fly   540 SLHKLYPYRNLLPLY-DTIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILE--SDP 601
               ::|...:||..| .|.:|.||         .|::|               :|...:.  |.|
 Worm   218 ---QMYEGYHLLGYYLYTAITNTT---------LFNYV---------------QPEKAISSMSIP 255

  Fly   602 GSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVAGGI 666
            |. .|...:...|..|:     |||..::..|
 Worm   256 GP-FGEIFINSNGQRIA-----GYDVLVVDKS--------------------------------- 281

  Fly   667 AMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGI--EAMLCCWLQQLQEFGGPEVDKPDLL 729
                               |::::|:.|:.:...|:..  :|.|...|.....| .|..|.|  |
 Worm   282 -------------------LNSNNFIMPLGTISTDKKCPDQACLNFVLNSTSSF-EPLKDVP--L 324

  Fly   730 KGSIGSL-KNLGFVIPGAAAPG-------SAGAITTTANGKSGSSATGSLARHNPAHLDMRARYN 786
            .|..|.: ...|.:|..|...|       ....|....||..|.|.:      ||..:..:
 Worm   325 CGFHGEICDQTGVIIAIAVIMGVLLMFIIILTTIRKCCNGSKGRSIS------NPWVIPFQ---- 379

  Fly   787 GDLVQLKEVNINGSAEL-------------------RTKAM----------DLLVMAHGLR---- 818
             |:..:...|..||..:                   |||.:          |..||...||
 Worm   380 -DVRFIDLTNTEGSQHMSIQSLQRNMEEKQRLQSLARTKHIATVDQVYVLADKYVMRDKLRYDKI 443

  Fly   819 -------------HENINPLIGWLSD-PNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLS--LL 867
                         |:|:|..:|...| .:...::::.|.||||.|.:...|.:...:.|..  .|
 Worm   444 DINLLYQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFL 508

  Fly   868 TDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSF---YESQGL------PPRTRS 923
            .|:::|:.|:|.|.:..||.||..||::|:.|::|::.:|:|..   :::.|.      .|..:|
 Worm   509 RDILKGLEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQIFTEDHTPVIKS 573

  Fly   924 AKELLWTAPELLRNMKLHQHHHQHGRI--QLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEE- 985
             :||.:..|.:.:..|.:...::...|  |.|.:. |:||||:|:.|::::.:....|..||.|
 Worm   574 -EELHYFDPAMKKIWKNYADRNERALITPQFGKKC-DMYSFGVILHEIILKKKFVEQLFDSPREE 636

  Fly   986 ----II------VKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNH 1040
                :|      :..:.|.|:|.|...:  ...:.|.::..|:.   .:|||          :..
 Worm   637 DDSVLIDDENDAIASRFPLPIIIPEGIE--MHNDLIKMLENCFG---SVRPD----------IAL 686

  Fly  1041 GRKV---------NFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLK 1096
            .||:         :.||.|.:.|..|:..|.|.::.||.:|:.|::|.:|||..:||.|||..||
 Worm   687 ARKIIDTVLKMSGSLVDLMIKNLTAYTQGLNETVKNRTAELEKEQEKGDQLLMELLPKSVANDLK 751

  Fly  1097 MGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAY 1161
            .|:||||:.:.:.||.:|||||||::.:...|::||.||:.:|..||..|:....||:|||||||
 Worm   752 NGIAVDPKVYENATILYSDIVGFTSLCSQSQPMEVVTLLSGMYQRFDLIISQQGGYKMETIGDAY 816

  Fly  1162 MVVSGLPVKI-PDHAEQIATMAL---DLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTM 1222
            .|.:||||.: .||.:.|..:||   |.||   .|.:.|.||..|..|.|.::||..|||:|...
 Worm   817 CVAAGLPVVMEKDHVKSICMIALLQRDCLH---HFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKA 878

  Fly  1223 PRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA---------RGGYAIEPRGLIDIKGKGM 1278
            |||..||:.|..||:|||:|...||.|:..::..|:.         |||..||        |.|.
 Worm   879 PRYACFGEAVILASKMESSGVEDRIQMTLASQQLLEENFPQFVCSNRGGRTIE--------GIGR 935

  Fly  1279 MNTFWLLGKKGFDKPLPAPPPIGE-------SHGLDESLIRNSITLKAQANKSRTSTNPSSSQSS 1336
            :.|:||.|...           ||       .:.|::.|.|   .:|........:|........
 Worm   936 ILTYWLEGVNA-----------GEQVKVVEFQNDLNDELSR---IMKKDGELLAAATALKPKDKM 986

  Fly  1337 SLAGESVEVKVEITPPTNADLASGTNLPNSYSLD---SNSTNTISPNATLCPEFPGKTTPSS--- 1395
            :||.|.|     |....|.:    ..|....:|.   ......|..|..|..|..|:..|..
 Worm   987 TLAKEKV-----IAERKNEE----ERLQRQQTLQEALEEHEEEIEMNEVLVDEDEGEGKPKEVDL 1042

  Fly  1396 TSPQSRKLSELTPE 1409
            ||..|.::.||..|
 Worm  1043 TSIVSTQMEELEDE 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	77/348 (22%)
		HNOBA	<1047..1095	CDD:462234	20/47 (43%)
		CYCc	1074..1266	CDD:214485	89/204 (44%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_type1	2..289	CDD:471960	68/415 (16%)
		Protein Kinases, catalytic domain	447..695	CDD:473864	63/264 (24%)
		CYCc	729..922	CDD:214485	86/195 (44%)