Protein Alignment CG34357 and gcy-18

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1083
• Identity: 293/1083 - (27%)
• Similarity: 471/1083 - (43%)
• Gaps: 188/1083 - (17%)

  Fly   299 HWNDARIFSG-HCHQLAEQLALDFNKTVVLWPCPRMKISSNFLP---SFEAISLAVQSISTKLNW 359
            |.:..|.|.| :|  .||..|:  .|....|..|.:..||  :|   |..::...:..:|:|...
 Worm   113 HVHQVRAFIGPYC--AAELEAV--TKMATFWNIPIISYSS--VPNAVSDRSVYKTLARVSSKNTN 171

  Fly   360 SQVDIYIG---DDNWGLGLAIAANL------------HVPYRIEIGRTIRDLHSQDKPGKAIIIT 409
            |..:..:.   ...| |.:|||.|.            .:.:|..:....:.:..::.....::.:
 Worm   172 SIAEATVALLLHYKW-LKVAIATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNS 235

  Fly   410 APLND----ASTILLL--STIELD----------------------WTEQARK--------DGQG 438
            ..|.|    |..|:.|  ||.||.                      |.:...|        ||:.
 Worm   236 GQLGDLAANARIIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTPWIGADGEM 300

  Fly   439 SRPGRQH--TKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSS----NLLVL 497
            .:..:.|  ..|::.|:..........|.:.:.:.|..:||....|......:..|    .|.:.
 Worm   301 LQRVKDHYANAIIVDDVNGFDDSVVSSFVEKIEKHGMQKSDIDVTNINGYLHLFDSLKLYALAIR 365

  Fly   498 TLLN--DRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTT 560
            .:||  |......|...:...|:  |....|.........:::|.                .:.|
 Worm   366 KVLNETDNEAYVTNGQFIWNRMR--RMKFEGVVSRSSSEENKDAG----------------AIGT 412

  Fly   561 TTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIHPGY 625
            ....|.::.:|.|....:...||..:........||...| |.:......:...:.|.....|..
 Worm   413 VLMDDVADRAPIFSAFYISPNRDKVMKMVNMESELISNCD-GLKNKSGCFQLKINDIKSGFWPSE 476

  Fly   626 DEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASD 690
            |..:.:...:....|..|..:..|.|..|:|::..|......:..|...|:|.|.|.:|
 Worm   477 DGSMPLDEPICGYRGQRCSYLLEISVGSLIILLILISVVFFFLFRYCENKQLEKMPWRI------ 535

  Fly   691 FVFPVDSRRVD-EGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGA 754
              |..|.:.:| |.:::|:                                          |.|:
 Worm   536 --FHDDLQFIDEEQVKSMM------------------------------------------SVGS 556

  Fly   755 ITT-TANGKSGSS--ATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHG 816
            :|| .:|.::|..  |...:..|...|   |.:....:..:||            .|.||.....
 Worm   557 VTTKLSNIQTGQKQHAIIGVNTHTTYH---RYKQRRPIKFIKE------------DMQLLTQMKQ 606

  Fly   817 LRHENINPLIG-WLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTS 880
            ..|:|:||.:| ..::.....:::.:||||::||::....:.||..|..:.:.|:..|:.|||.|
 Worm   607 AVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDITLGLEYLHAS 671

  Fly   881 PLRVHGALTSRNCVVDARWVLKITDYGLNS---FYESQGL-----------PPRTRSAKELLWTA 931
            |:..||:||...|::|..|::|::|||:.:   .:|.||.           ..:...|..:::.|
 Worm   672 PIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKDSDDKSQASQATSIIYMA 736

  Fly   932 PELLRNMKLHQHHHQHGRIQ-------LGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVK 989
            ||||:|.:.::   :.|..|       |..|.||:||||::|.|::.|..|: ..:.:..|::..
 Worm   737 PELLKNRETNK---RRGMDQSWVKQSMLRRQAGDIYSFGMVMYEILFRSLPF-RDNTNISELVDY 797

  Fly   990 IKKPPPLIRPSV-SKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQM 1053
            :......:.|.: ::....|:...::|.||:|.|::||....|....:|:.. .|.:.||.|.:|
 Worm   798 LADGSKTVSPEIQNQMGLHPDLNALLRDCWSENPEIRPSIRRVRLNTEMVLK-TKGSLVDQMMKM 861

  Fly  1054 LEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVG 1118
            :|:|:||||:|:.|||..|:....:.:|||.::||:.||.:||||.:|.|:.:|..||.||||||
 Worm   862 MEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVG 926

  Fly  1119 FTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIP-DHAEQIATMA 1182
            ||||.:..:|::||::||.|||.||..|.....|||||||||||||||:|.:.. :|:..||..|
 Worm   927 FTTICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTA 991

  Fly  1183 LDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRI 1247
            ||:......:.:.|.|...::.|.|.|||...|||||||.|||||||||||.:|||||||:...|
 Worm   992 LDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMI 1056

  Fly  1248 HMSQETRDRLDARGG-YAIEPRGLIDIKGKGMMNTFWLLGKKG 1289
            .||:|....:.|... :....||.:.:||||...||||..:.|
 Worm  1057 QMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDRVG 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	78/302 (26%)
		HNOBA	<1047..1095	CDD:462234	22/47 (47%)
		CYCc	1074..1266	CDD:214485	96/193 (50%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575	62/357 (17%)
		Protein Kinases, catalytic domain	549..846	CDD:473864	83/357 (23%)
		CYCc	882..1073	CDD:214485	96/190 (51%)