Protein Alignment CG34357 and gcy-12

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_494995.2
• Gene: gcy-12 / 173902
• WormBaseID: WBGene00001538
• Length: 1679
• Species: Caenorhabditis elegans
• Alignment Length: 1689
• Identity: 423/1689 - (25%)
• Similarity: 627/1689 - (37%)
• Gaps: 565/1689 - (33%)

  Fly   210 LSGFIKLLELPKYTSVIKTLNAGIMVASHVDVDQNSTIYIGTPSQPRQQHRLHSKQEQEPHRHHH 274
            |:..:..|....|.||:    :|.:||:.|:::|:..:.      |..|
 Worm   125 LNQIVHCLTTDAYVSVV----SGALVAAIVEINQDKDLI------PAYQ---------------- 163

  Fly   275 EDSKAKQFPAGE---EESHSSGETEENHWN-DARIFSG---HCHQLAEQLALDFNKTVVLWPCPR 332
                 .::..|.   .:|||:....| ||. .||:|.|   :|...| .:|...|..::.:.|..
 Worm   164 -----LKYVFGNTCGNDSHSTRLFME-HWQAGARVFIGPEKNCKTEA-AMAASQNLPIISYRCND 221

  Fly   333 MKIS---------SNFLPSFEAISLAVQSISTKLNWSQVDIYIGDDNWGLGLAIAANLHVPYRIE 388
            ..||         :..:|....|..|..|:..:.||.:                   ..|.|.::
 Worm   222 QDISRDDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRK-------------------FSVVYDVK 267

  Fly   389 IGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTE---QARKDGQ----GSRPGRQHT 446
            .|:...:|.   :..|.::.|....:.....:::..:|::::   .:::|.|    ..:...|.|
 Worm   268 KGQVKNELF---ETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKSTMQTT 329

  Fly   447 KILLIDMAASSLDTQHGFYKYLSRMG------------------------GSQSDAFARNT---- 483
            :|.|      :.|....|...||.||                        .|.::.|.|||
 Worm   330 RIYL------TFDNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNVYHSMNNHFLRNTMTYL 388

  Fly   484 --------GSPAEVVSSNLLVLTLL-------NDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPP 533
                    .|..:::......|:::       :.|...|...||  ..|.:|......|.|
 Worm   389 HHSWDANNSSDRKMLDYARSALSIIPTPVKLNSQRFYNFWKKAG--DYMHHFGVQKADNLK---- 447

  Fly   534 SGHRNA------------SLHKLY----------PYRNLLPLYDTIVTTTTQS--------DTSE 568
             |:|.|            ::|:|.          |..:...:.|.||....:|        |...
 Worm   448 -GNRIACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDMRIDERG 511

  Fly   569 TSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSY--ISHSIH--------P 623
            .| :.:|.:|...:.||:..         :|||             ||  :.|::.        |
 Worm   512 NS-KGNFSLLSWQKVAPIMN---------KSDP-------------SYYPLDHALDLTAIFVEAP 553

  Fly   624 GYD---EWLLVSSVLLWQCG------AICWTIAAIC-----------VCLLVIMIAGIVAGGIAM 668
            ..|   .....||.:.|..|      .:|......|           |.:::|.:..:|..|..:
 Worm   554 DKDRLPNLQFKSSRIQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTL 618

  Fly   669 RNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSI 733
             ||...:|..|     .||....:.|.:.|||..|:.......|.|.......:...|...|..:
 Worm   619 -NYIRSRRFEK-----ELSMIWKIDPYEVRRVVGGVNNESTASLMQSDVMQFAKTKTPWWSKAPV 677

  Fly   734 GSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMR--ARYNGDLVQLKEV- 795
                                            ..||           ||  |.|.|.||.||::
 Worm   678 --------------------------------QGTG-----------MRGLASYKGTLVGLKDLM 699

  Fly   796 ------NINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMD 854
                  ::...|:...:||      ..|.|.|:|..:|.:.......:|.:|||:|||.|:|..:
 Worm   700 YGRKPKDLTREAKKELRAM------RQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNE 758

  Fly   855 EIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPP 919
            .:|||..:..|.:.|||:||.|:|.|.|::||.|.|.||::.:||.|:|.|:||....|......
 Worm   759 NLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDS 823

  Fly   920 RTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLG---TQLGDVYSFGIIMQEVVVRGEPYCML-- 979
            .....:..||||||.:.         .:|.:.:.   |...|.||||||..|:..|..||.:.
 Worm   824 SYNIWENFLWTAPEAMT---------INGSLAISNPPTPKADAYSFGIIFHEIFTREGPYKIYVQ 879

  Fly   980 ------SLSPEEIIVKIKK----------PPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDF 1028
                  ..:|::..|:.:.          ..|..||..|..........:|..||...|..||:|
 Worm   880 RGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEF 944

  Fly  1029 NSVYERFKMLNHG-RKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVA 1092
            .::..:.|.|.|. .|.|.:|.|..|:|||...||:|:.|||.:|..|:::::.||.||||||||
 Worm   945 KTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVA 1009

  Fly  1093 EKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETI 1157
            |:|..|..|.||.|..||||||||||||||:...:|::||..||.|||:||:.|..|:|||||||
 Worm  1010 EQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETI 1074

  Fly  1158 GDAYMVVSGLP--VKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGL 1220
            |||||||||:|  ..:..||||||.||:.:|.....|::.|....||.:|||:|||||.|||||.
 Worm  1075 GDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGK 1139

  Fly  1221 TMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA-RGGYAIEPRGLIDIKGKGMMNTFWL 1284
            |||||.||||||||||||||.|.:.|||.|..|:..|.: ..|:.:|.||.:.|||||.|.|:||
 Worm  1140 TMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWL 1204

  Fly  1285 LGKKGF-------DK-------PLPAPPPIGESHGLD---------------------------- 1307
            .|:.|:       ||       |.|.....|.|.|::
 Worm  1205 NGRAGYEFTETIEDKMVVPDIFPRPNLKNRGSSWGVNRESSLSLATEKSSQIMKRQSAAMNRNNQ 1269

  Fly  1308 --------------------------------ESLIRNSITL---------KAQANK-------- 1323
                                            |||:..|.:|         |:.|:|
 Worm  1270 DVIYYNQPLNSGGFTSRGTSNREMPKLYEEDRESLLNQSASLLGSRTSGRKKSTASKYNGFSASR 1334

  Fly  1324 --SRTSTNPSSS-----------------QSSSLA-GESVEVKVEITPPTNADLASGTNLPNSYS 1368
              |.|.:|.|||                 :|:||. ||  ::.:|....||....|...:||:.|
 Worm  1335 MFSSTISNASSSRPSRPSTFDHDTLALRKRSTSLPDGE--KLNLEFIETTNLANNSVPAIPNNIS 1397

  Fly  1369 -----------LDSNSTNTISPNATLCPEFPGKTT------------------------------ 1392
                       :|..|:.:.||:.:..|.:...||
 Worm  1398 SLEPVFRKASIIDGYSSQSESPSQSQYPSYRDLTTGPHQRKRGIATVFPVRKRSLSCGDAVPLKI 1462

  Fly  1393 --------------PSST----------------------------------------------- 1396
                          |.|:
 Worm  1463 NENGASGSITTAVSPRSSCRALDPTMKLAARASSPDEIIFQEDDEDALIDNDSLLTSNGNSKSED 1527

  Fly  1397 --------------------SPQSRKLSELTP----ENLLNPNSFNRLPSSTGGSSSRLYKK--- 1434
                                ||.:::..:.:|    :...|.|..|...||...|.|||:::
 Worm  1528 VLRTCPQPRRKNKHSFLRDPSPLAKRFRDASPFGKKKPFWNSNKSNEHTSSPADSISRLFRRFRG 1592

  Fly  1435 --IEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYLYGSVAGGAGGGQAGGGACASIALSGSGCG 1496
              :.|..||    ||| |....||.....|:.:.: |.:.|.....:.|.....|::.|...||
 Worm  1593 GSVNEYADL----NHY-CDDEDESGRANGYEMQEM-GKMTGRQREQRNGSRTNRSVSCSPDECG 1650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	89/307 (29%)
		HNOBA	<1047..1095	CDD:462234	25/47 (53%)
		CYCc	1074..1266	CDD:214485	114/194 (59%)
gcy-12	NP_494995.2	Periplasmic_Binding_Protein_type1	140..527	CDD:471960	80/455 (18%)
		PK_GC-A_B	648..957	CDD:270944	93/366 (25%)
		CYCc	991..1183	CDD:214485	113/191 (59%)