DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gcy-12

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	1689	Identity:	423/1689 - (25%)
Similarity:	627/1689 - (37%)	Gaps:	565/1689 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 LSGFIKLLELPKYTSVIKTLNAGIMVASHVDVDQNSTIYIGTPSQPRQQHRLHSKQEQEPHRHHH 274
            |:..:..|....|.||:    :|.:||:.|:::|:..:.      |..|
Worm   125 LNQIVHCLTTDAYVSVV----SGALVAAIVEINQDKDLI------PAYQ---------------- 163

  Fly   275 EDSKAKQFPAGE---EESHSSGETEENHWN-DARIFSG---HCHQLAEQLALDFNKTVVLWPCPR 332
                 .::..|.   .:|||:....| ||. .||:|.|   :|...| .:|...|..::.:.|..
Worm   164 -----LKYVFGNTCGNDSHSTRLFME-HWQAGARVFIGPEKNCKTEA-AMAASQNLPIISYRCND 221

  Fly   333 MKIS---------SNFLPSFEAISLAVQSISTKLNWSQVDIYIGDDNWGLGLAIAANLHVPYRIE 388
            ..||         :..:|....|..|..|:..:.||.:                   ..|.|.::
Worm   222 QDISRDDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRK-------------------FSVVYDVK 267

  Fly   389 IGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTE---QARKDGQ----GSRPGRQHT 446
            .|:...:|.   :..|.::.|....:.....:::..:|::::   .:::|.|    ..:...|.|
Worm   268 KGQVKNELF---ETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKSTMQTT 329

  Fly   447 KILLIDMAASSLDTQHGFYKYLSRMG------------------------GSQSDAFARNT---- 483
            :|.|      :.|....|...||.||                        .|.::.|.|||
Worm   330 RIYL------TFDNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNVYHSMNNHFLRNTMTYL 388

  Fly   484 --------GSPAEVVSSNLLVLTLL-------NDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPP 533
                    .|..:::......|:::       :.|...|...||  ..|.:|......|.|
Worm   389 HHSWDANNSSDRKMLDYARSALSIIPTPVKLNSQRFYNFWKKAG--DYMHHFGVQKADNLK---- 447

  Fly   534 SGHRNA------------SLHKLY----------PYRNLLPLYDTIVTTTTQS--------DTSE 568
             |:|.|            ::|:|.          |..:...:.|.||....:|        |...
Worm   448 -GNRIACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDMRIDERG 511

  Fly   569 TSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSY--ISHSIH--------P 623
            .| :.:|.:|...:.||:..         :|||             ||  :.|::.        |
Worm   512 NS-KGNFSLLSWQKVAPIMN---------KSDP-------------SYYPLDHALDLTAIFVEAP 553

  Fly   624 GYD---EWLLVSSVLLWQCG------AICWTIAAIC-----------VCLLVIMIAGIVAGGIAM 668
            ..|   .....||.:.|..|      .:|......|           |.:::|.:..:|..|..:
Worm   554 DKDRLPNLQFKSSRIQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTL 618

  Fly   669 RNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSI 733
             ||...:|..|     .||....:.|.:.|||..|:.......|.|.......:...|...|..:
Worm   619 -NYIRSRRFEK-----ELSMIWKIDPYEVRRVVGGVNNESTASLMQSDVMQFAKTKTPWWSKAPV 677

  Fly   734 GSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMR--ARYNGDLVQLKEV- 795
                                            ..||           ||  |.|.|.||.||::
Worm   678 --------------------------------QGTG-----------MRGLASYKGTLVGLKDLM 699

  Fly   796 ------NINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMD 854
                  ::...|:...:||      ..|.|.|:|..:|.:.......:|.:|||:|||.|:|..:
Worm   700 YGRKPKDLTREAKKELRAM------RQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNE 758

  Fly   855 EIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPP 919
            .:|||..:..|.:.|||:||.|:|.|.|::||.|.|.||::.:||.|:|.|:||....|......
Worm   759 NLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDS 823

  Fly   920 RTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLG---TQLGDVYSFGIIMQEVVVRGEPYCML-- 979
            .....:..||||||.:.         .:|.:.:.   |...|.||||||..|:..|..||.:.
Worm   824 SYNIWENFLWTAPEAMT---------INGSLAISNPPTPKADAYSFGIIFHEIFTREGPYKIYVQ 879

  Fly   980 ------SLSPEEIIVKIKK----------PPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDF 1028
                  ..:|::..|:.:.          ..|..||..|..........:|..||...|..||:|
Worm   880 RGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEF 944

  Fly  1029 NSVYERFKMLNHG-RKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVA 1092
            .::..:.|.|.|. .|.|.:|.|..|:|||...||:|:.|||.:|..|:::::.||.||||||||
Worm   945 KTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVA 1009

  Fly  1093 EKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETI 1157
            |:|..|..|.||.|..||||||||||||||:...:|::||..||.|||:||:.|..|:|||||||
Worm  1010 EQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETI 1074

  Fly  1158 GDAYMVVSGLP--VKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGL 1220
            |||||||||:|  ..:..||||||.||:.:|.....|::.|....||.:|||:|||||.|||||.
Worm  1075 GDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGK 1139

  Fly  1221 TMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA-RGGYAIEPRGLIDIKGKGMMNTFWL 1284
            |||||.||||||||||||||.|.:.|||.|..|:..|.: ..|:.:|.||.:.|||||.|.|:||
Worm  1140 TMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWL 1204

  Fly  1285 LGKKGF-------DK-------PLPAPPPIGESHGLD---------------------------- 1307
            .|:.|:       ||       |.|.....|.|.|::
Worm  1205 NGRAGYEFTETIEDKMVVPDIFPRPNLKNRGSSWGVNRESSLSLATEKSSQIMKRQSAAMNRNNQ 1269

  Fly  1308 --------------------------------ESLIRNSITL---------KAQANK-------- 1323
                                            |||:..|.:|         |:.|:|
Worm  1270 DVIYYNQPLNSGGFTSRGTSNREMPKLYEEDRESLLNQSASLLGSRTSGRKKSTASKYNGFSASR 1334

  Fly  1324 --SRTSTNPSSS-----------------QSSSLA-GESVEVKVEITPPTNADLASGTNLPNSYS 1368
              |.|.:|.|||                 :|:||. ||  ::.:|....||....|...:||:.|
Worm  1335 MFSSTISNASSSRPSRPSTFDHDTLALRKRSTSLPDGE--KLNLEFIETTNLANNSVPAIPNNIS 1397

  Fly  1369 -----------LDSNSTNTISPNATLCPEFPGKTT------------------------------ 1392
                       :|..|:.:.||:.:..|.:...||
Worm  1398 SLEPVFRKASIIDGYSSQSESPSQSQYPSYRDLTTGPHQRKRGIATVFPVRKRSLSCGDAVPLKI 1462

  Fly  1393 --------------PSST----------------------------------------------- 1396
                          |.|:
Worm  1463 NENGASGSITTAVSPRSSCRALDPTMKLAARASSPDEIIFQEDDEDALIDNDSLLTSNGNSKSED 1527

  Fly  1397 --------------------SPQSRKLSELTP----ENLLNPNSFNRLPSSTGGSSSRLYKK--- 1434
                                ||.:::..:.:|    :...|.|..|...||...|.|||:::
Worm  1528 VLRTCPQPRRKNKHSFLRDPSPLAKRFRDASPFGKKKPFWNSNKSNEHTSSPADSISRLFRRFRG 1592

  Fly  1435 --IEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYLYGSVAGGAGGGQAGGGACASIALSGSGCG 1496
              :.|..||    ||| |....||.....|:.:.: |.:.|.....:.|.....|::.|...||
Worm  1593 GSVNEYADL----NHY-CDDEDESGRANGYEMQEM-GKMTGRQREQRNGSRTNRSVSCSPDECG 1650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	89/307 (29%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	114/194 (59%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365	92/510 (18%)
		ANF_receptor	140..519	CDD:279440	79/447 (18%)
		PK_GC-A_B	648..957	CDD:270944	93/366 (25%)
		TyrKc	688..951	CDD:197581	82/277 (30%)
		HNOBA	<967..1012	CDD:285003	24/44 (55%)
		CYCc	991..1183	CDD:214485	113/191 (59%)
		Guanylate_cyc	1018..1206	CDD:278633	112/187 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820