DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gcy-28

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001021600.1	Gene:	gcy-28 / 172051	WormBaseID:	WBGene00020131	Length:	1276	Species:	Caenorhabditis elegans

Alignment Length:	1266	Identity:	365/1266 - (28%)
Similarity:	554/1266 - (43%)	Gaps:	304/1266 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 GFIKLLELPKYTSVIKTLNAGIMVASHVDVDQNSTIYIGTPSQPRQQHRLHSKQE-------QEP 269
            ||.....|...|.|...||.||.:.:          ..|.||      .|:||:|       |..
Worm   124 GFADNYGLATVTKVTAGLNGGIPILT----------TSGMPS------LLNSKKEYPFLTRMQGS 172

  Fly   270 HR-----------HHHEDSKAKQFPA---------------------GEEESHSSGETEENHWND 302
            :|           :|.|||.:|...:                     .::||..:|.|
Worm   173 YRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGAT------- 230

  Fly   303 ARIFSGHCH---QLAEQLALDFNKTVVL-WP--CPRMKISSNFLPSFEAISLAVQSISTKLNWSQ 361
                |.||:   ...::...:.:||... |.  .|:.....:.:...|.....::.||.:   |.
Worm   231 ----SSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQ---SN 288

  Fly   362 VDIYIGDDNWGLGLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIEL 426
            |.|.....:....:.:||:       ::|..        ..|:.:.|..   |.||   .|..|.
Worm   289 VIILCASPDTVREIMLAAH-------DLGMA--------TSGEYVFINI---DVST---GSHAEQ 332

  Fly   427 DWTEQARKDGQGSRPGRQHTKIL-LIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVV 490
            .|......:.:.:...::..:.| .|.:..|.||....| :...:....|...:...||...|:
Worm   333 PWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNF-ELRVKERADQKYNYTNITGKDYEM- 395

  Fly   491 SSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGH------------RNASLHK 543
              |..:....:   .:.|.|..|..|:|:...|.||:.......|.            .|...:.
Worm   396 --NNFISAFYD---AVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYS 455

  Fly   544 LYPYRNLLPLYDTIVTTTTQSDTS---ETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRG 605
            .|...:|.|:.:..|.....|..|   :|..|..:|......|.|:..|
Worm   456 DYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLHWVGGKPPTDLPICGY---------------- 504

  Fly   606 GGSVVEGGGSYISHSIHPGY--DEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVAGGIAM 668
                        ..|..|||  ..:||:.|.                  ||::::.|:..  ...
Worm   505 ------------DKSKCPGYPLHVYLLMGSF------------------LLILVLVGLFI--FFW 537

  Fly   669 RNYFL--------------------------RKRLSKGPN---------KIVLSAS--------- 689
            |.|.|                          :|:..|..|         .::.|.|
Worm   538 RRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKKRKNHNDYLPESDPLLRSTSRSSVNSDKF 602

  Fly   690 --DFVFPV----------DSRRVDEGIEAMLCCWLQ-------QLQEFGGPEVDKPDLLK----G 731
              |.:.|:          .:|::...|:..|..:.:       :.|:.||.   .|:.|:    |
Worm   603 DEDSLIPIRFRLRSSSSGTTRKISAMIDRKLSIFTRKKSTPPSESQKNGGL---TPNSLQKAENG 664

  Fly   732 SIGSLKNLGFVIP----GAAAPGSAGAITTTANG-------------------------KSGS-S 766
            ....:..:.|.:|    ..::|.|.......:|.                         |||| .
Worm   665 DCSPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGG 729

  Fly   767 ATGSLARHNPAHLDMRARYNGDLVQLKEVNINGS----AEL-RTKAMDLLVMAHGLRHENINPLI 826
            :..::|::|.......|.:.|.:|.:|::||:..    .:| |.:.|:|..| ..|:|::|....
Worm   730 SVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKM-KDLQHDHITRFT 793

  Fly   827 GWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSR 891
            |...|.....:|.:||.:|||:|:|..::|:||...:.|||.|||:|:.:||.|.:|.||.|.|.
Worm   794 GACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSS 858

  Fly   892 NCVVDARWVLKITDYGLNSFY--ESQGLPPRTRSA--KELLWTAPELLRNMKLHQHHHQHGRIQL 952
            |||||:|:|||:||:||:..:  |...|......|  |::|||||||||:....         .:
Worm   859 NCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAP---------PM 914

  Fly   953 GTQLGDVYSFGIIMQEVVVRGEPYCMLS--LSPEEIIVKIKKP-----PPLIRPSVSK------- 1003
            |||.||:|||.||:.|::.|...:.:.:  |||.||:.:::||     .|| ||.||:
Worm   915 GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPL-RPWVSETGEGEGD 978

  Fly  1004 GAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKV-NFVDTMFQMLEKYSNNLEELIRE 1067
            .|.....:::|..||:|.|..||:.:||.:..:.||...:. |.||.:.:.:|:|:||||.|:.|
Worm   979 DALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEE 1043

  Fly  1068 RTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVV 1132
            ||::...|:||.|:||:::||.::|:.|..|.||..|.:..||||||||||||::::..:|:|||
Worm  1044 RTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVV 1108

  Fly  1133 DLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHL 1197
            .||||||..||..::.:.||||||||||||||||||.:..|||.|||.|:|.|||:...|.::|.
Worm  1109 TLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKVKNFVIRHR 1173

  Fly  1198 PGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGG 1262
            |...|:||||:|:|...|||||..|||||||||||||:|||||.|...:||:||:|.|.|....|
Worm  1174 PHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAG 1238

  Fly  1263 YAIEPRGLIDIKGKGMMNTFWLLGKKGFDKP 1293
            :.:|.||.:::|||||..|:||.|.|..:.|
Worm  1239 FKLELRGSVEMKGKGMQTTYWLRGYKDVEIP 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	110/301 (37%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	109/191 (57%)
gcy-28	NP_001021600.1	PBP1_NPR_like	42..486	CDD:107368	79/419 (19%)
		ANF_receptor	64..465	CDD:279440	74/398 (19%)
		PK_GC-A_B	722..1016	CDD:270944	111/304 (37%)
		STYKc	741..1008	CDD:214568	103/277 (37%)
		HNOBA	<1026..1071	CDD:285003	19/44 (43%)
		CYCc	1050..1233	CDD:214485	107/182 (59%)
		Guanylate_cyc	1077..1262	CDD:278633	108/184 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920