DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	1095	Identity:	393/1095 - (35%)
Similarity:	549/1095 - (50%)	Gaps:	220/1095 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 AEQLALDFNKTVVLWPCPRMKISSNFLPSFEAISLAVQSISTKLNWSQVDIYIG-DDNW---GLG 374
            ||.||.:....:|.|.||..:.:....|:....:.|:..:.....|::|.:... .|.|   |..
Mouse   139 AELLAQEAGVALVPWGCPGTRAAGTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRA 203

  Fly   375 LAIAANLH-VPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTI--LLLSTIELDWTEQARKDG 436
            |:.|.... :|..:     :..:.:.|:.| |......:.|...:  .|.|.:...|...| :.|
Mouse   204 LSTALRARGLPVAL-----VTSMETSDRSG-AREALGRIRDGPRVRGKLPSRVRARWVGPA-ESG 261

  Fly   437 QGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQ-------SDAFARNTGSPAEVVSSNL 494
            |.|.|.....:..::.|...|:           .:||.:       ::..|...||
Mouse   262 QRSEPASVSVRSAVVIMVMHSV-----------LLGGEEQRYLLEAAEELALTDGS--------- 306

  Fly   495 LVLTLLNDRH----------RLFLNAAGL------MATMQNFRAPLNGNYKDPPPSGHRNASLHK 543
            ||....:..|          ..|:|::.|      :.|:.. |.|..|:.:|    ..|.|..|:
Mouse   307 LVFLPFDTLHYALSPGPEALAAFVNSSQLRRAHDAVLTLTR-RCPPGGSVQD----SLRRAQEHQ 366

  Fly   544 LYP----YRNLLPLYDTI-------------------------VTTTTQSDTSETS--------- 570
            ..|    .:.:.||:.||                         .:...|...::.|
Mouse   367 ELPLDLNLKQVSPLFGTIYDAVFLLAGGVKRARTAVGGGWVSGASVARQVREAQVSGFCGVLGRT 431

  Fly   571 --PQFDFVVLDIVRDAPVATYKWRPLLILESDPGS-RGGGSVV---EGGGSYISHSIHPGYDEWL 629
              |.|..:..|...:...||:...|:|      || |..|:.:   .||.:       ||.|
Mouse   432 EEPSFVLLDTDASGEQLFATHLLDPVL------GSLRSAGTPMHFPRGGPA-------PGPD--- 480

  Fly   630 LVSSVLLWQCGAICW-TIAAIC----------VCLLVIMIAGIVAGGIA--MRNYFLRKRLSKGP 681
                       ..|| ....||          |..|:::..|:....:|  :|:..|..:::.||
Mouse   481 -----------PSCWFDPDVICNGGVEPGLVFVGFLLVIGMGLTGAFLAHYLRHRLLHMQMASGP 534

  Fly   682 NKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGA 746
            |||:|:..|..|                     |...||   ....:::||..||
Mouse   535 NKIILTLEDVTF---------------------LHPPGG---SSRKVVQGSRSSL---------- 565

  Fly   747 AAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLL 811
             |..||..|.:..:....|:..|              .|.||.|.||:........:|.......
Mouse   566 -ATRSASDIRSVPSQPQESTNVG--------------LYEGDWVWLKKFPGEHHMAIRPATKTAF 615

  Fly   812 VMAHGLRHENINPLIGWL----SDPNRT------AMVFDYCSRGSLQDVLIMDEIKLDWSFRLSL 866
            .....|||||:...:|..    :|...|      |:|.::|:||||.|:|...||||||.|:.||
Mouse   616 SKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKLDWMFKSSL 680

  Fly   867 LTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTA 931
            |.||::||||||...: .||.|.|||||||.|:|||:||:|.....|:|.:.|...||::.||||
Mouse   681 LLDLIKGMRYLHHRGV-AHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTA 744

  Fly   932 PELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPL 996
            |||||:..|.:.         ||..|||:|..|||||||.|..||.||.|:|||:|.:::.||||
Mouse   745 PELLRDPSLERR---------GTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPL 800

  Fly   997 IRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNL 1061
            .||.||...||.|.|.:|.|||||.|::||..:..::.||.:|.|||.|.:|:|.:|||:||:||
Mouse   801 CRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTNIIDSMLRMLEQYSSNL 865

  Fly  1062 EELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHC 1126
            |:|||||||:|:.|::||::||.:|||.||||.||||.:|:||.|.:||:|||||||||||:|..
Mouse   866 EDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMS 930

  Fly  1127 SPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSG 1190
            .|::||||||||||:|||.|.|::|||||||||||||.||||.:... ||.:||.|:||:|...|
Mouse   931 EPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVG 995

  Fly  1191 RFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRD 1255
            .|.::|:|.||:::|||||:|||.||||||||||||||||||||||||||||..:|||::..|..
Mouse   996 SFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVR 1060

  Fly  1256 RLDARG-GYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPP---PIGESHGL 1306
            .|.|.. |:.:|.||..::||||:.:|:||:|:.||:||:|.||   |...:||:
Mouse  1061 ILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPGASNHGI 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	123/287 (43%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	124/193 (64%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	68/363 (19%)
		PK_GC-2D	570..845	CDD:270945	125/298 (42%)
		HNOBA	<854..899	CDD:400168	29/44 (66%)
		CYCc	879..1070	CDD:214485	124/190 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2386
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002312
OrthoInspector	1	1.000	-	-		otm44295
orthoMCL	1	0.900	-	-		OOG6_103194
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4933
SonicParanoid	1	1.000	-	-		X1738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.810