Protein Alignment CG34357 and Gucy2d

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_001124165.1
• Gene: Gucy2d / 14918
• MGIID: 106030
• Length: 1117
• Species: Mus musculus
• Alignment Length: 1109
• Identity: 399/1109 - (35%)
• Similarity: 541/1109 - (48%)
• Gaps: 238/1109 - (21%)

  Fly   280 KQFPAGEEESHSSGETEENHWNDARIF-----SGHCHQLAEQLALDFNKTVVLWPCPRMKISSNF 339
            |..|.|.:..|:.. |...|.|....|     .|.| ..|..||..:.|::..|.|...:...:.
Mouse   115 KVLPTGCDTPHALA-TFVAHKNIVAAFVGPVNPGFC-SAAALLAQGWGKSLFSWACEAPEGGGDL 177

  Fly   340 LPSFEAISLAVQSISTKLNW-------SQVDIYIGDDNWGLGLAIAANLH-VPYRI-------EI 389
            :|:..:.:..:.|:.....|       |..||::   .....||.|...| :|..:       |.
Mouse   178 VPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWV---TTAQQLATAFRTHGLPIGLVTSLGPGEK 239

  Fly   390 GRT--IRDLHSQDKPGKAIII----TAPLNDASTILLLSTIELDWTEQARKDGQGSRPGRQHTKI 448
            |.|  .:.|||..  |..|::    :|.|.......||   ...|.|       |...||
Mouse   240 GATEVCKQLHSVH--GLKIVVLCMHSALLGGLEQTTLL---HCAWEE-------GLTDGR----- 287

  Fly   449 LLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGL 513
             |:.:...:|                   .||...|      :.:.|||    |.|.....|...
Mouse   288 -LVFLPYDTL-------------------LFALPYG------NRSYLVL----DDHGPLQEAYDA 322

  Fly   514 MATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTTTQSDTSETSPQFDFVVL 578
            :.|:....:|.:..:.....||...|:|..    ..:.||:.||               :|.|:|
Mouse   323 VLTVSLESSPESHAFTATEMSGGATANLEP----EQVSPLFGTI---------------YDAVIL 368

  Fly   579 ---------------------DIVRDAPVATYKWRPLLILESDPGSRGGGSVV---EGGGSYI-- 617
                                 |.||...||.:..|   |.....|.|....|:   :|.||.:
Mouse   369 LAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQR---IRTDGKGRRLAQYVILDTDGEGSQLVP 430

  Fly   618 SH--------------SIH------PGYDEWLLVSSVLLWQCGAICW-TIAAICV-------CLL 654
            :|              .||      |.:|              |.|| ....:|:       .||
Mouse   431 THILDTSTWQVQPLGKPIHFPGGSPPAHD--------------ASCWFDPNTLCIRGVQPLGSLL 481

  Fly   655 VIMIAGIVA--GGIAMRNYFLR-----KRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWL 712
            .:.||.::|  ||...  ||:|     .||.:||::|:|::.:..|                  |
Mouse   482 TLTIACVLALVGGFLA--YFIRLGLQQLRLLRGPHRILLTSQELTF------------------L 526

  Fly   713 QQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPA 777
            |:......|.||                          |.....:..:|.|..|.|...||..||
Mouse   527 QRTPSRRRPHVD--------------------------SGSESRSVVDGGSPRSVTQGSARSLPA 565

  Fly   778 HLDMR--ARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFD 840
            .|:..  |.|.|:.|.||:.....:.:||..::..|.....:||||:...:|....|..:|||.:
Mouse   566 FLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLE 630

  Fly   841 YCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITD 905
            :|:||||:|:|..:.::|||:|:.|||.||:||:||||.... .||.|.|||||||.|:||||||
Mouse   631 HCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRF-PHGRLKSRNCVVDTRFVLKITD 694

  Fly   906 YGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVV 970
            :|...|.||........:.:|||||||||||.         .|:   .|..|||:|..||:|||:
Mouse   695 HGYAEFLESHCSSRPQPAPEELLWTAPELLRG---------PGK---ATFKGDVFSLAIILQEVL 747

  Fly   971 VRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERF 1035
            .|..|||...||.||||.|:..||||.||.||....|.|.|.:|:.||.|.||.||..:.:|.:|
Mouse   748 TRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQF 812

  Fly  1036 KMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLA 1100
            |.:|.|:|.:.||:|.:||||||.:||:|::||||:|::||:|||:||::|||.|||..||||..
Mouse   813 KSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTT 877

  Fly  1101 VDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVS 1165
            |:||.|..||||||||||||||:|...|::||..||||||:|||.:::::|||||||||||||.|
Mouse   878 VEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVAS 942

  Fly  1166 GLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFG 1229
            |||.:..: ||.:||.:|||:|..:|.|.::|.|.||:::|.|||:|||.|||||||||||||||
Mouse   943 GLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFG 1007

  Fly  1230 DTVNTASRMESTGSSWRIHMSQET-RDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKP 1293
            |||||||||||||..:|||:||.| :..|....||.|:.||..::||||:..|:||.||.||.:|
Mouse  1008 DTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRP 1072

  Fly  1294 LPAP 1297
            ||.|
Mouse  1073 LPTP 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864	125/279 (45%)
		HNOBA	<1047..1095	CDD:462234	30/47 (64%)
		CYCc	1074..1266	CDD:214485	123/193 (64%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	82/403 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..557		7/53 (13%)
		PK_GC-2D	554..818	CDD:270945	124/276 (45%)
		CYCc	855..1044	CDD:214485	121/188 (64%)
		Interaction with NCALD. /evidence=ECO:0000250|UniProtKB:P51839	874..915		26/40 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1117