DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	1100	Identity:	326/1100 - (29%)
Similarity:	512/1100 - (46%)	Gaps:	269/1100 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LALDFNKTV--VLWPCPRMKISSNFLPSFEAISLAVQSISTK-LNWSQVDIYIG-----DDNWGL 373
            |:.|:.:|:  :|.|..::..   ||..|    ..|.:.|.| .:|:...:|..     |..|.|
Mouse   149 LSCDYKETLTRILPPARKLMY---FLVDF----WKVNNASFKPFSWNSSYVYKNGSEPEDCFWYL 206

  Fly   374 GLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQARKDGQG 438
            .   |....|.|..|: ...:|:..:.:..:. |:|.....::.|::..|.|..:      |.:|
Mouse   207 N---ALEAGVSYFSEV-LNFKDVLRRSEQFQE-ILTGHNRKSNVIVMCGTPESFY------DVKG 260

  Fly   439 SRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGSPAEVVSSNLLVLTLLNDR 503
            .....:.|.::|:|:.::..                    |..||.:|..:  .|:|||||.::
Mouse   261 DLQVAEDTVVILVDLFSNHY--------------------FEENTTAPEYM--DNVLVLTLPSE- 302

  Fly   504 HRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTTTQSDTSE 568
                             ::..|.:..:...||..:.||    .|.....|:..::.|..::..:.
Mouse   303 -----------------QSTSNTSVAERFSSGRSDFSL----AYLEGTLLFGHMLQTFLENGENV 346

  Fly   569 TSPQF----------DF---VVLDIVRD---------APVATYKWRPLLILESDPGSRGGGSVVE 611
            |.|:|          .|   |.||...|         ..:.|.|::  ::::.|........|.|
Mouse   347 TGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYK--VLMKYDTHKNKTIPVAE 409

  Fly   612 GGGSYI--SHSIH---PGYDEWLLVSSVLLWQCGAICWTIAAICVCLLVIMIAGIVAGGIAMRNY 671
             ..::|  :|.:.   ||....:|:.:|         :|:..|.|.||:|.:       :.:|.|
Mouse   410 -NPNFIWKNHKLPNDVPGLGPQILMIAV---------FTLTGILVVLLLIAL-------LVLRKY 457

  Fly   672 -----FLRKRLSKGPNKIVLSASDFVFPV-------------DSRRVDEGIEAMLCCWLQQLQEF 718
                 ..:|:.|..|       |:.:||:             |.||.|.         :|::::.
Mouse   458 RRDHALRQKKWSHIP-------SENIFPLETNETNHISLKIDDDRRRDT---------IQRVRQC 506

  Fly   719 GGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRA 783
               :.||..::      ||:|                                 :|:
Mouse   507 ---KYDKKKVI------LKDL---------------------------------KHS-------- 521

  Fly   784 RYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQ 848
              :|:..:.:::::|           .|:.:.   :.|:....|.:....|...|.:||.||||:
Mouse   522 --DGNFSEKQKIDLN-----------KLLQSD---YYNLTKFYGTVKLDTRIFGVVEYCERGSLR 570

  Fly   849 DVL-----IMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGL 908
            :||     ..|...:||.|::|:|.|:.:||.|||:|.:.|||.|.|.|||||:|.|:||||:|.
Mouse   571 EVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGC 635

  Fly   909 NSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRG 973
            ||.     |||     |:.||||||.||...:             :|.||||||.||.||:::|.
Mouse   636 NSI-----LPP-----KKDLWTAPEHLRQATI-------------SQKGDVYSFAIIAQEIILRK 677

  Fly   974 EPYCMLSL-SPEEIIVKIK----KPPPLIRPSVSKGAAPPEAINI---MRQCWAEQPDMRPDFNS 1030
            |.:..||. ...|.|.:::    ||   .||.:....|..:.:.:   ::.||.|.|:.||||..
Mouse   678 ETFYTLSCRDHNEKIFRVENSYGKP---FRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKK 739

  Fly  1031 VYER----FKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSV 1091
            :...    |.:.:..:..:::||:.:.|:.||.|||.|:.|||:....||.:.:.|...:||..|
Mouse   740 IESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLV 804

  Fly  1092 AEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVET 1156
            .:.||....|:||.:.:||||||||||||||..:.:|::|||:|||:|..||..::.::||||||
Mouse   805 VKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVET 869

  Fly  1157 IGDAYMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGL 1220
            |||||:|.||||::..: ||..|:.||||:|...|.|.::||||:|:.:|||:|:|||.|||||:
Mouse   870 IGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGI 934

  Fly  1221 TMPRYCLFGDTVNTASRMESTGSSWRIHMSQET---RDRLDARGGYAIEPRGLIDIKGKGMMNTF 1282
            .|||||||||||||||||||||...|||||..|   ..|.|.:  :..|.||...:||:|...|:
Mouse   935 KMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQ--FLYEVRGETYLKGRGTETTY 997

  Fly  1283 WLLGKKGFDKPLPAPPPIGESHGLD---ESLIRNSITLK-AQANKSRTSTNPSSSQSSSL 1338
            ||.|.|..:..||:||.:.....|.   ..:|.:::..: |...|||..|..:|.:...|
Mouse   998 WLTGMKDQEYNLPSPPTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFL 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	91/294 (31%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	107/195 (55%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	62/330 (19%)
		PKc_like	480..749	CDD:304357	100/369 (27%)
		STYKc	502..744	CDD:214568	95/333 (29%)
		CYCc	787..978	CDD:214485	107/192 (56%)
		Guanylate_cyc	814..1001	CDD:278633	108/188 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820