DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gucy2d

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	1108	Identity:	389/1108 - (35%)
Similarity:	542/1108 - (48%)	Gaps:	245/1108 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 GHCHQLAEQLALDFNKTVVLWPCPRMKISSNFLPSF----EAISLAVQSISTKLNWSQVDIYIGD 368
            |:| ..|..||.::||.::.|.|.:.::.....|:|    ...|..:.|:.....|:.|.|...:
Zfish   154 GYC-TAATLLAKNWNKGILSWGCLKAEMDEEMYPTFLRPLPLSSRVLFSVLRFFRWAHVGIVTAE 217

  Fly   369 -DNW-GLGLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAPLNDASTILLLSTIELDWTEQ 431
             |.| ..|..:||:|.. ..:.:|:.:.....::.|.:|:                        |
Zfish   218 GDMWEATGHELAASLRA-LGLPVGKVVTMEQDKEGPRQAL------------------------Q 257

  Fly   432 ARKDGQGSR-----------PGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSDAFARNTGS 485
            |.:|....|           .|.:..::|...:....:|..:.|..|         |....:.
Zfish   258 AIRDTDRVRVVIMCMHSALIGGEEQYQLLTTALEMRMIDRGYIFIPY---------DTLLYSL-- 311

  Fly   486 PAEVVSSNLL------------VLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRN 538
            |.|.|...:|            |||:..|:..            |||....|...:.....|..:
Zfish   312 PYENVKYPILANDSKLRRAYDGVLTVTMDQGE------------QNFYEAFNAAQESFEIRGSTS 364

  Fly   539 AS--LHKLYPYRNLLPLYDTIVTTTTQSDTSETSPQFDFVVLDI--------------------- 580
            |.  ...:.|:..  .:|:.|..|...::.|..|....:|..|:
Zfish   365 AEEVTRWVSPFFG--TIYNMIYYTAMAAEQSRASSGGRWVSGDLLSQNEGGFEFDGFNQRISGGT 427

  Fly   581 ------VRDAPVATYKWRPLLILESDPGSRGGGSVV--------------EGGGSYISHSIH--- 622
                  ||.|           :|:||    |.||.:              .||..|:..|||
Zfish   428 NGEGMQVRYA-----------VLDSD----GSGSSLYRTHALEASHTYGKYGGLKYLGKSIHFAG 477

  Fly   623 --PGYDEWLLVSSVLLWQCGAICWTIAAICVC-----------LLVIMIAGIVAGGI---AMRNY 671
              |..|              |.|| .:....|           ||:..|..|...||   .:|.|
Zfish   478 ASPSSD--------------ANCW-FSPYIACSGGLDGVTLFFLLMFFIVLIAGAGILFLQVRKY 527

  Fly   672 ----FLRKRLSKG--PNKIVLSASDFVF--PVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDL 728
                |....:..|  |.||||:..|.||  ...|||                      :::...:
Zfish   528 GAGGFFGAFIGGGGSPTKIVLTLDDLVFINTTLSRR----------------------KLNDESM 570

  Fly   729 LKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRARYNGDLVQLK 793
            ||..:.                    :.|..:..||.|...|....:..     |.:.||.|.||
Zfish   571 LKSQLD--------------------VKTPRHSVSGRSYITSTPETSNV-----AVFEGDWVWLK 610

  Fly   794 EVNINGS-AELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIK 857
            :.....| .|:......:.|....:||||:|..:|...|.....:|.::|:||||:|:|..:|::
Zfish   611 KCPCADSITEISESTQTIFVKLRDMRHENLNLFLGLFMDTGIFGIVTEHCTRGSLEDLLNNEEMR 675

  Fly   858 LDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTR 922
            |||.|:.|||.||:|||:|||...: :||.|.|||||||.|:|||:||||.|.....|.:.....
Zfish   676 LDWMFKSSLLLDLIRGMKYLHNRGI-IHGRLKSRNCVVDGRFVLKVTDYGFNEILNCQNIILEDN 739

  Fly   923 SAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEII 987
            :.::..|||||:|||..|.:.         ||..||||||.||||||:.|..|:|||.:.|||||
Zfish   740 APEDQFWTAPEILRNPDLKKK---------GTYPGDVYSFSIIMQEVISRCAPFCMLDMPPEEII 795

  Fly   988 VKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQ 1052
            .|::.||||.||:||...||.:.|.:|:|.|:|:|:.||.|..::.:||.:|.|:|.|.:|:|.:
Zfish   796 EKVRSPPPLCRPTVSMDEAPLDVIQLMKQAWSEEPEQRPTFEDIFRQFKSMNKGKKTNIIDSMLR 860

  Fly  1053 MLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIV 1117
            |||:||:|||:|||||||:|::||:||:.||.:|||.|||..||.|..|.||.|::||:||||||
Zfish   861 MLEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALALKTGKPVKPEHFAEVTLYFSDIV 925

  Fly  1118 GFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKI-PDHAEQIATM 1181
            |||||:|...|::||||||||||.||..|..::|||||||||||||.||:|.:. ..||.::|.|
Zfish   926 GFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDVYKVETIGDAYMVASGVPNRNGTRHAAEMANM 990

  Fly  1182 ALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWR 1246
            :||:||..|.|.::|:|.|.:::|||||:||..||||||.|||||||||||||||||||||..:|
Zfish   991 SLDILHCIGTFKMRHMPDVKVKIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGLPYR 1055

  Fly  1247 IHMSQETRDRLDA-RGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPP---PIGESHG-- 1305
            ||::|.|.|.|:: :.||.|:.||..::||||:..||||:|:.|||||||.||   |...:||
Zfish  1056 IHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEETFWLVGRDGFDKPLPIPPDLTPGASNHGIS 1120

  Fly  1306 LDE 1308
            |||
Zfish  1121 LDE 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	120/278 (43%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	119/193 (62%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366	69/381 (18%)
		PK_GC-2D	581..849	CDD:270945	120/282 (43%)
		HNOBA	<858..903	CDD:311573	29/44 (66%)
		CYCc	883..1075	CDD:214485	119/191 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	245	1.000	Domainoid score	I2137
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	585	1.000	Inparanoid score	I965
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002312
OrthoInspector	1	1.000	-	-		otm26554
orthoMCL	1	0.900	-	-		OOG6_103194
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970