DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and gc2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	1099	Identity:	398/1099 - (36%)
Similarity:	564/1099 - (51%)	Gaps:	215/1099 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 GHCHQLAEQLALDFNKTVVLWPCPRMKISS-----NFLPSFEAISLAVQSISTKLNWSQVDIY-I 366
            |:| :.|..|...:||.|..|.|...::..     .|..:....||.:.|......|:.|.|. .
Zfish   135 GYC-EAASLLGKSWNKAVFSWSCIEHELDDVRSHPTFARTMPVPSLVLLSFMRHFRWAHVGIISS 198

  Fly   367 GDDNW--------------GLGLAI---AANLHVPYRIEIG--RTIRDL-------HS---QDKP 402
            .:|.|              ||.:.|   |.|.|...|..:.  |.:.||       ||   ..:.
Zfish   199 SEDVWVEAAIKLANALRSHGLPVGIVTSARNDHTSVRQTLAKVRKVADLRLVILVMHSVLIGGRT 263

  Fly   403 GKAIIITA---PLNDASTI------LLLSTIELDWTEQARKDGQGSRPGRQHTKILLIDMAASSL 458
            .|.::.||   .:.|.|.:      |..|......|:.|.:  ..|:..|.:..:|.|.:.:..
Zfish   264 QKLLLETAHDMRMTDGSLVFMSYDTLFYSLPYHHVTQPALR--YNSKLLRAYDAVLTITIESPK- 325

  Fly   459 DTQHGFYKYLSRMGGSQSDAFARNTGSPAEV------VSSNLLVLTLLNDRHRL-FLNAAGLMAT 516
              :..||:...:   :|.|........|.:|      :.|:::.:.     |.: .:.|||...:
Zfish   326 --EQSFYQAFEK---AQEDGELPKHLKPQQVSPLFGTIYSSIVFMA-----HAVQSVRAAGQWMS 380

  Fly   517 MQNFRAPLNGNYKDPPPSGHRNASLHKLYPYRNLLPLYDTIVTTTTQSDTSETSPQFDFVVLD-I 580
                    .||..       :||        ||||          .:..:|..:...||.:|| :
Zfish   381 --------GGNIA-------QNA--------RNLL----------FKGGSSLQANSSDFGMLDYV 412

  Fly   581 VRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYISHSIH------PGYDEWLLVSSVLLWQC 639
            :.|....:::.:|...:|...      .:|.    ::...||      |..|
Zfish   413 ILDTDGFSWELQPTYRIEMQT------DMVR----FLGRHIHFPYAGPPRTD------------- 454

  Fly   640 GAICWTIAAICVCL----LVIMIAGIVAGGIAM-----RNYFLRKRLSK-----GPNKIVLSASD 690
             :.||....| :|.    |..||:..:.|.:.:     .:|.:|::::|     |||||:|:.:|
Zfish   455 -SSCWFTHGI-ICRGGVNLFHMISMFLLGFLFIFLSIGCSYCIRRKINKIRLVRGPNKILLTLND 517

  Fly   691 --FVFPVDSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAG 753
              |:.|                                        ||.|....:..:.|..:..
Zfish   518 VTFINP----------------------------------------SLSNKKLSVDDSKASDTRM 542

  Fly   754 AITTTANGKSGSSATGSLARHNPAHLDMR--ARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHG 816
            :|       |..|....::..:||..:..  |.|.||...:|.:.......:.....|:..:...
Zfish   543 SI-------SERSLVSPMSSQSPATYENSNVAIYEGDWAWMKRLPYGTFRSITPNTSDVFELMKD 600

  Fly   817 LRHENINPLIGWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSP 881
            ||||||||.:|:..|....|:|.::||||||:|:|:.|::||||.|:.||:.||::||:|||...
Zfish   601 LRHENINPFLGFFHDCGVFAIVTEFCSRGSLEDLLVNDDVKLDWMFKSSLILDLIKGMKYLHHRN 665

  Fly   882 LRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQ 946
            : .||.|.|||||||.|:||||||||.|...|||..|.....|::|||||||:||......|
Zfish   666 V-CHGRLKSRNCVVDGRFVLKITDYGYNEVLESQRFPYIEPPAEDLLWTAPEILRGSYPGLH--- 726

  Fly   947 HGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAI 1011
                  ||..||||||.|||||||:||.|:|||..:.:||:.|::||||:.||.||...||.|.|
Zfish   727 ------GTHSGDVYSFSIIMQEVVMRGPPFCMLENTFDEIVQKVRKPPPMCRPIVSPDHAPMECI 785

  Fly  1012 NIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIER 1076
            .:|:|||.|||:.||.|:.::::||.:|.|:|.|.:|:|.:|||:||:|||||||||||:|:||:
Zfish   786 QLMKQCWNEQPEKRPTFDEIFDQFKNVNKGKKTNIIDSMLRMLEQYSSNLEELIRERTEELEIEK 850

  Fly  1077 KKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTI 1141
            :|||:||.:|||.||||.||:|..|:||.|..|::|||||||||||:|:..|::||||||||||.
Zfish   851 QKTEKLLTQMLPPSVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTT 915

  Fly  1142 FDATINAYNVYKVETIGDAYMVVSGLPVKIPD---HAEQIATMALDLLHQSGRFNVKHLPGVPLQ 1203
            |||.|..::|||||||||||||.||:||  |:   ||.:||.||||:|...|.|.::|:|.||::
Zfish   916 FDAVIGNHDVYKVETIGDAYMVASGVPV--PNGNRHAAEIANMALDILSAVGTFRMRHMPDVPVR 978

  Fly  1204 LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQET-RDRLDARGGYAIEP 1267
            :|||||||||.||||||||||||||||||.|||||||||..:|||:...| :..::.:.||.:|.
Zfish   979 IRIGLHTGPCVAGVVGLTMPRYCLFGDTVTTASRMESTGLPYRIHVHSSTVKILMELKLGYRVEL 1043

  Fly  1268 RGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRT 1326
            |...::|||.:..|:||.|:.||.||||.||.:  ..||:....:  :.||....|..|
Zfish  1044 RARTELKGKRIEETYWLTGRDGFTKPLPVPPVL--KSGLESKDFK--VMLKKAVRKIST 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	129/279 (46%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	124/195 (64%)
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	71/361 (20%)
		PK_GC-2D	551..815	CDD:270945	127/273 (47%)
		HNOBA	<824..869	CDD:311573	32/44 (73%)
		CYCc	848..1040	CDD:214485	123/193 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	245	1.000	Domainoid score	I2137
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	585	1.000	Inparanoid score	I965
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002312
OrthoInspector	1	1.000	-	-		otm26554
orthoMCL	1	0.900	-	-		OOG6_103194
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4933
SonicParanoid	1	1.000	-	-		X1738
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860