DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and Npr2

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_446290.1	Gene:	Npr2 / 116564	RGDID:	620851	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	1106	Identity:	361/1106 - (32%)
Similarity:	503/1106 - (45%)	Gaps:	236/1106 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 WPCPRMKISSNFLPSFEAISLAVQS-----------ISTKLNWS---------QVDIYI-GDDNW 371
            |..||:.         .|::|||::           :|::|:.:         .||:.: .|.:.
  Rat    40 WAWPRVG---------PAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDL 95

  Fly   372 GLG----------LAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIITAP----LNDASTILLLS 422
            .||          ...|::.|:|. :..|.......::::..:.::.|.|    |.:     .:.
  Rat    96 LLGPGCVYPAASVARFASHWHLPL-LTAGAVASGFAAKNEHYRTLVRTGPSAPKLGE-----FVV 154

  Fly   423 TI--ELDWTEQ-------ARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGG-SQSD 477
            |:  ..:||.:       ||.|   .||.....:.:...:..|:|..||  ..|....|| .|:.
  Rat   155 TLHGHFNWTARAALLYLDARTD---DRPHYFTIEGVFEALQGSNLSVQH--QVYTREPGGPEQAT 214

  Fly   478 AFARNTG------SPAEVVSSNLLVL---TLLNDRHRLF--------LNAAGLMAT--------- 516
            .|.|..|      .|.|::...||..   .|.|..:..|        |.|....||
  Rat   215 HFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRT 279

  Fly   517 -------MQNFRAPLNGNYKDPPPSGHRNASLHKLYPYR------------NLLP--LYDTIV-- 558
                   .:.|:..|...|::||...::......|...|            ||:.  .||.|:
  Rat   280 QEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLY 344

  Fly   559 -----TTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILESDPGSRGGGSVVEGGGSYIS 618
                 .|..:..|.|..       |.||.......|.....|::......|....|:...|...|
  Rat   345 AQVLNETIQEGGTREDG-------LRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLES 402

  Fly   619 HSIHPGYDEWLLVSSVLLWQCGAICW---------------------------TIAAICVCLLVI 656
            ....|. ..:......:.|....|.|                           |:|.:.:...:.
  Rat   403 GDFQPA-AHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGIT 466

  Fly   657 MIAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRVDEGIEAMLCCWLQQLQE--FG 719
            .|...|:..:..|...|.|.|:                           :||  |..:.:|  ||
  Rat   467 FIMFGVSSFLIFRKLMLEKELA---------------------------SML--WRIRWEELQFG 502

  Fly   720 GPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLARHNPAHLDMRAR 784
                 ..|......||...|       :..||:.....||:||....|       |..|
  Rat   503 -----NSDRYHKGAGSRLTL-------SLRGSSYGSLMTAHGKYQIFA-------NTGH------ 542

  Fly   785 YNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRGSLQD 849
            :.|::|.:|.|| ....||..:.:..|.....::..::...||...||....:|.:||.||||||
  Rat   543 FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD 606

  Fly   850 VLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYES 914
            :|..|.|.|||.||.||:.|||:||.:||.|.:..||:|.|.|||||:|:|||||||||.|| .|
  Rat   607 ILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASF-RS 670

  Fly   915 QGLPPRTRS--AKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGEPYC 977
            ...|..:.:  ||: ||||||||....|.         ..|.|..|||||.||:||:.:|..|:.
  Rat   671 TAEPDDSHALYAKK-LWTAPELLSGNPLP---------TTGMQKADVYSFAIILQEIALRSGPFY 725

  Fly   978 M--LSLSPEEIIVKIKK-PPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLN 1039
            :  |.|||:||:.|::. ..|..|||:.:.....|.:.:|.:|||:.|..||||..:....:..|
  Rat   726 LEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFN 790

  Fly  1040 HGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPE 1104
            .....:.:|.:...:|:|:||||:|:.|||:....|::|.|.||.::||.||||:||.|..|..|
  Rat   791 KEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAE 855

  Fly  1105 EFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPV 1169
            .|..||||||||||||.::|..:|:|||.|||||||.|||.|:.::||||||||||||||||||.
  Rat   856 AFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920

  Fly  1170 KIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1233
            :... ||.:||.|||.||.....|.::|.|...|:||||:||||.|||||||.||||||||||||
  Rat   921 RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN 985

  Fly  1234 TASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLG-KKGFDKPLPAP 1297
            |||||||.|.:.:||:|..|:|.||..|.:.:|.||.:::||||.|.|:|||| :||       |
  Rat   986 TASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG-------P 1043

  Fly  1298 P 1298
            |
  Rat  1044 P 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	111/282 (39%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	119/192 (62%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607	76/408 (19%)
		PK_GC-A_B	518..792	CDD:270944	117/298 (39%)
		HNOBA	<798..846	CDD:400168	22/47 (47%)
		CYCc	825..1009	CDD:214485	116/183 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820