Protein Alignment CG34357 and Gucy2e

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_570093.2
• Gene: Gucy2e / 113911
• RGDID: 69322
• Length: 1123
• Species: Rattus norvegicus
• Alignment Length: 1150
• Identity: 411/1150 - (35%)
• Similarity: 571/1150 - (49%)
• Gaps: 244/1150 - (21%)

  Fly   280 KQFPAGEEESHSSGETEENHWNDARIF-----SGHCHQLAEQLALDFNKTVVLWPCPRMKISSNF 339
            |..|.|.:..|:.. |...|.|....|     .|:| ..|..||..:.|::..|.|...:.....
  Rat   115 KILPTGCDTPHALA-TFVAHRNTVAAFIGPVNPGYC-PAAALLAQGWGKSLFSWACGAPEGGGAL 177

  Fly   340 LPSFEAISLAVQSISTKLNWSQVDIYIG-DDNW---GLGLAIAANLH-VPYRI-------EIGRT 392
            :|:..:::..:.|:.....|:::.|... .|.|   ...||.|...| :|..:       |.|.|
  Rat   178 VPTLPSMADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGAT 242

  Fly   393 --IRDLHSQDKPGKAIII----TAPLNDASTILLLSTIELDWTEQARKDG--QG----------- 438
              .:.|||..  |..|::    :|.|......:||..        |||:|  .|
  Rat   243 EVCKQLHSVH--GLKIVVLCMHSALLGGLEQTVLLRC--------ARKEGLTDGRLVFLPYDTLL 297

  Fly   439 -SRPGRQHTKILLID----------MAASSLDT---QHGFYKYLSRMGGSQSDAFARNTG----S 485
             :.|.|..:.::|.|          :...||||   .|.|.....| ||:     |.|.|    |
  Rat   298 FALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMR-GGT-----AANLGPEQVS 356

  Fly   486 P--AEVVSSNLLVLTLLN--------------DRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPS 534
            |  ..:..:.:|:...||              ..|...|:.||.     :.|..::|       .
  Rat   357 PLFGTIYDAVILLAHALNHSEAHGTGLSGAHLGNHIRALDVAGF-----SQRIRIDG-------K 409

  Fly   535 GHRNASLHKLYPYRNLLPLYDTIVTTTTQSDTSETSPQFDFVVLDIVRDAPVATYKWRPLLILES 599
            |.|             ||.|   |...|..:.|:..|..   :||      |:|.:.:||
  Rat   410 GRR-------------LPQY---VILDTNGEGSQLVPTH---ILD------VSTQQVQPL----- 444

  Fly   600 DPGSRGGGSVVEGGGSYISHSIHPGYDEWLLVSSVLLWQCGAICW-TIAAICV----------CL 653
                  |.:|...|||      .|..|              |.|| ....:|:          .|
  Rat   445 ------GTAVHFPGGS------PPARD--------------ASCWFDPNTLCIRGVQPLGSLLTL 483

  Fly   654 LVIMIAGIVAGGIAMRNYFLR-----KRLSKGPNKIVLSASDFVF--PVDSRR---VDEGIEAML 708
            .:..:..:|.|.:|   ||:|     .||.:||::|:|:..:..|  ...|||   ||.|.|:
  Rat   484 TITCVLALVGGFLA---YFIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSES-- 543

  Fly   709 CCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSSATGSLAR 773
                :.:.:.|.|:    .:::||..|:
  Rat   544 ----RSVVDGGSPQ----SVIQGSTRSV------------------------------------- 563

  Fly   774 HNPAHLDMR--ARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTA 836
              ||.|:..  |.|.|:.|.||:.....:.:||..::.||.....:||||:...:|....|..:|
  Rat   564 --PAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSA 626

  Fly   837 MVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVL 901
            ||.::|:||||:|:|..::::|||:|:.|||.||:||:||||.... .||.|.|||||||.|:||
  Rat   627 MVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHF-PHGRLKSRNCVVDTRFVL 690

  Fly   902 KITDYGLNSFYESQ-GLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGII 965
            ||||:|...|.||. ...|:. :.:|||||||||||..:   .....|:   .|..|||:|.|||
  Rat   691 KITDHGYAEFLESHCSFRPQP-APEELLWTAPELLRGPR---RPWGPGK---ATFKGDVFSLGII 748

  Fly   966 MQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNS 1030
            :|||:.|..|||...||.||||.|:..||||.||.||....|.|.|.:|:.||.|.||.||..:.
  Rat   749 LQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQ 813

  Fly  1031 VYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKL 1095
            :|.:||.:|.|:|.:..|:|.:||||||.:||.|::||||:|::||:|||:||::|||.|||..|
  Rat   814 IYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHAL 878

  Fly  1096 KMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDA 1160
            |||..|:||.|..||||||||||||||:|...|::||..||||||:|||.:::::||||||||||
  Rat   879 KMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDA 943

  Fly  1161 YMVVSGLPVKIPD-HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPR 1224
            |||.||||.:..: ||.:||.|||::|..:|.|.::|.|.||:::|.|||:|||.||||||||||
  Rat   944 YMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPR 1008

  Fly  1225 YCLFGDTVNTASRMESTGSSWRIHMSQET-RDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKK 1288
            ||||||||||||||||||..:|||:|:.| :..|....||.|:.||..::||||:..|:||.||.
  Rat  1009 YCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKT 1073

  Fly  1289 GFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSS 1333
            ||.:.||.|..|.......:.:.:...|..|:|.:|  ...|.||
  Rat  1074 GFCRSLPTPLSIQPGDPWQDHINQEIRTGFAKARQS--LAEPRSS 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	123/280 (44%)
		CYCc	1074..1266	CDD:214485	122/193 (63%)
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	86/395 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..556		9/36 (25%)
		PK_GC-2D	554..824	CDD:270945	126/316 (40%)
		CYCc	861..1050	CDD:214485	120/188 (64%)
		Interaction with NCALD. /evidence=ECO:0000269|PubMed:18178149	880..921		26/40 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8011
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002312
OrthoInspector	1	1.000	-	-		otm46397
orthoMCL	1	0.900	-	-		OOG6_103194
Panther	1	1.100	-	-	LDO	PTHR11920
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1738
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.780