DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and ADCY6

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	235	Identity:	71/235 - (30%)
Similarity:	122/235 - (51%)	Gaps:	31/235 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1072 LDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEF----------SDVTIYFSDIVGFTTIAAHC 1126
            |..|.::.|:||..:||..||.::|..:....|:.          .:|:|.|:||.|||::|:.|
Human   331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQC 395

  Fly  1127 SPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGR 1191
            :..::|..||:|:..||......:..:::.:||.|..|||||....|||.....|.:|::.....
Human   396 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISL 460

  Fly  1192 FNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDR 1256
              |:.:.||.:.:|:|:|:|....||:||...::.::.:.|..|:.||:.|.:.|||:::.|...
Human   461 --VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQY 523

  Fly  1257 LDARGGYAIEPRGLIDIKGKG----------MMNTFWLLG 1286
            |:  |.|.:||       |:|          .:.||.:||
Human   524 LN--GDYEVEP-------GRGGERNAYLKEQHIETFLILG 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	62/201 (31%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	11/36 (31%)
		Guanylate_cyc	370..554	CDD:306677	58/194 (30%)
		DUF1053	582..668	CDD:399378
		Guanylate_cyc	970..1164	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810