DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and ADCY5

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens

Alignment Length:	362	Identity:	90/362 - (24%)
Similarity:	163/362 - (45%)	Gaps:	73/362 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1075 ERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEF----------SDVTIYFSDIVGFTTIAAHCSPV 1129
            |.::.|:||..:||..||.::|..:....|:.          .:|:|.|:||.|||::|:.|:..
Human   424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ 488

  Fly  1130 QVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNV 1194
            ::|..||:|:..||......:..:::.:||.|..|||||....|||.....|.:|::.....  |
Human   489 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISL--V 551

  Fly  1195 KHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDA 1259
            :.:.||.:.:|:|:|:|....||:||...::.::.:.|..|:.||:.|.:.|||:::.|.:.|:
Human   552 REVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN- 615

  Fly  1260 RGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLI-------RNSITL 1317
             |.|.:||       |.|.....:|                 :.|.::..||       :....:
Human   616 -GDYEVEP-------GCGGERNAYL-----------------KEHSIETFLILRCTQKRKEEKAM 655

  Fly  1318 KAQANKSRTST---NPSSSQS-----SSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNST 1374
            .|:.|:.||::   ||....:     :.|.|..|..:::         ..|...|.    |.|:.
Human   656 IAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMK---------RMGFEDPK----DKNAQ 707

  Fly  1375 NTISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENL 1411
            .:.:|...: .||.|:..      .:|.:..|..|::
Human   708 ESANPEDEV-DEFLGRAI------DARSIDRLRSEHV 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	62/200 (31%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	10/33 (30%)
		Guanylate_cyc	460..633	CDD:306677	57/200 (29%)
		DUF1053	668..760	CDD:399378	16/90 (18%)
		Guanylate_cyc	1087..1281	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810