Protein Alignment CG34357 and ADCY3

DIOPT Version :9

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 134/542 - (24%)
• Similarity: 214/542 - (39%)
• Gaps: 140/542 - (25%)

  Fly   952 LGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQ 1016
            :|.|:..|:||.|.:.           |||||..||..:......:...|:......|.:..|:.
Human   169 VGWQVFFVFSFFITLP-----------LSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQL 222

  Fly  1017 CWAEQPDMRPDFNSVY----------ERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQ 1071
                   :|....:|:          ..:.|.:...:..|::.. |.|| ...||||
Human   223 -------LREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEAR-QSLE-VKMNLEE-------- 270

  Fly  1072 LDIERKKTEQLLNRMLPSSVAEKL-----KMGLAVDPEEFS--------DVTIYFSDIVGFTTIA 1123
               :.::.|.|:..:||..||:::     |.....|.::|:        :|:|.|:||||||.::
Human   271 ---QSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLS 332

  Fly  1124 AHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQ 1188
            :.||..::|.|||:|:..||.....|:..:::.:||.|..:.|||....|||.....|.|.::..
Human   333 SACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEA 397

  Fly  1189 SGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG----------- 1242
            ......|...||  .:|:|:|||....||:|....:|.::...|..|::||:.|
Human   398 ISYVREKTKTGV--DMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERL 460

  Fly  1243 ----------SSW-RIHMSQETRDRLDARGGYAIEPR------GLIDIKGKGMMNTFWLLGKKGF 1290
                      ..| |:|:||.|.|.|  :|.:.:||.      ..::.||   :.|:.::..|
Human   461 YSCVVAPTLRLRWERVHISQSTMDCL--KGEFDVEPGDGGSRCDYLEEKG---IETYLIIASK-- 518

  Fly  1291 DKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEITPPTNA 1355
                |........:||:.|.:.|..              |:||:|||.|      .:|...|..:
Human   519 ----PEVKKTATQNGLNGSALPNGA--------------PASSKSSSPA------LIETKEPNGS 559

  Fly  1356 DLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENLLNPNSFNRL 1420
            ..:||          |.|......:|.|.|      |..|..|.||.|.....:|...||...||
Human   560 AHSSG----------STSEKPEEQDAQLFP------TTLSHLPHSRCLPGSQADNPSFPNPRRRL 608

  Fly  1421 PSSTGGSSSRLYKKIEEMMDLS 1442
                     ||....:.::|.|
Human   609 ---------RLQDLADRVVDAS 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	19/98 (19%)
		CYCc	1074..1266	CDD:214485	65/226 (29%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	34/164 (21%)
		CYCc	273..490	CDD:214485	65/220 (30%)
		Guanylate_cyc	310..516	CDD:278633	61/212 (29%)
		CYCc	925..1143	CDD:214485
		Guanylate_cyc	956..1163	CDD:278633

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810