Protein Alignment CG34357 and ADCY2

DIOPT Version :10

• Sequence 1: NP_001356914.1
• Gene: CG34357 / 5740349
• FlyBaseID: FBgn0085386
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 86/296 - (29%)
• Similarity: 154/296 - (52%)
• Gaps: 43/296 - (14%)

  Fly  1057 YSNNLEELIRERTEQ-----------LDIERKKTEQLLNRMLPSSVAEKL-----------KMGL 1099
            |..:|.||..::|.|           |:.|:::.|:||..:||:.:|.::           |.|.
Human   207 YHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQ 271

  Fly  1100 AVDPEEF--------SDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVET 1156
            ..:...|        ::|:|.::||||||.:|:.|||.::|.:||:|:..||.........:::.
Human   272 MENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKI 336

  Fly  1157 IGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLT 1221
            :||.|..|||||:.:|:||:....|.||:.....:  |:...||.:.:|:|:|:|....||:||.
Human   337 LGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKK--VRDATGVDINMRVGVHSGNVLCGVIGLQ 399

  Fly  1222 MPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKG----KGMMNTF 1282
            ..:|.::...|..|:.||:.|...|:|:|..|.:.|:  |.|.:| .|..||:.    :.::.|:
Human   400 KWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN--GAYKVE-EGDGDIRDPYLKQHLVKTY 461

  Fly  1283 WLLGKKGFDKPLPAPPPI-GESHGLDESLIRNSITL 1317
            :::..||..:   :|..: ...|.||.:.:|.|:.:
Human   462 FVINPKGERR---SPQHLFRPRHTLDGAKMRASVRM 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	Protein Kinases, catalytic domain	763..1041	CDD:473864
		HNOBA	<1047..1095	CDD:462234	14/48 (29%)
		CYCc	1074..1266	CDD:214485	66/210 (31%)
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	80/267 (30%)
		Guanylate_cyc	281..465	CDD:425528	61/188 (32%)
		Adcy_cons_dom	495..600	CDD:461877	86/296 (29%)
		Guanylate_cyc	878..1077	CDD:425528
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993