DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and ADCY1

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	242	Identity:	76/242 - (31%)
Similarity:	123/242 - (50%)	Gaps:	27/242 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1044 VNFVDTMFQMLEKYSNN---------LEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGL 1099
            ||......::|.:.|..         :|:.:|     |:.|.:|.|:||..:||.:||.::|...
Human   224 VNMYGVFVRILTERSQRKAFLQARSCIEDRLR-----LEDENEKQERLLMSLLPRNVAMEMKEDF 283

  Fly  1100 AVDPEEF---------SDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVE 1155
            ...||..         .:|:|.|:||||||.:|:.|:..::|.|||:|:..||......:..:::
Human   284 LKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIK 348

  Fly  1156 TIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGL 1220
            .:||.|..||||.....|||.....|.||::...  .:|.....|.|.:|:|||||....||:||
Human   349 ILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTI--TSVAEATEVDLNMRVGLHTGRVLCGVLGL 411

  Fly  1221 TMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEP 1267
            ...:|.::.:.|..|:.||:.|...::|:::.|...|:  |.|.:||
Human   412 RKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLN--GDYEVEP 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	67/200 (34%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831	19/72 (26%)
		CYCc	258..453	CDD:214485	66/198 (33%)
		Guanylate_cyc	294..476	CDD:278633	57/167 (34%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520
		CYCc	826..1037	CDD:214485
		Guanylate_cyc	859..1056	CDD:278633
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810