DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34357 and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001238874.1	Gene:	gucy1b1 / 100150304	ZFINID:	ZDB-GENE-090313-160	Length:	608	Species:	Danio rerio

Alignment Length:	302	Identity:	115/302 - (38%)
Similarity:	167/302 - (55%)	Gaps:	29/302 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1008 PEAINIMRQCWAEQPDMRPDFNSVYERFKMLN----HGRKVNFVDTMFQMLEKYSNNLE-ELIRE 1067
            ||..||:..|   .|.:. :.:.:..|...|:    |....:.|....|..|:|....| |::.:
Zfish   314 PETENILFLC---SPSVM-NLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTD 374

  Fly  1068 RTEQ----LDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAA-HCS 1127
            |.:.    |:.|:|||::||..:||.|||.:|:....|..:.:.:|||.||.||||....: |.|
Zfish   375 RLQHTLRALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHAS 439

  Fly  1128 ---PVQVVDLLNDLYTIF----DATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDL 1185
               .:::|:||||:||.|    |:..|.| ||||||:||.||.|||||.....||:.|..:|||:
Zfish   440 AEGAIKIVNLLNDIYTRFDILTDSRKNPY-VYKVETVGDKYMTVSGLPEPCTHHAKSICHLALDM 503

  Fly  1186 LHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMS 1250
            :..:|:..|..   .|:|:.||:|||....||:|..||||||||:|||..||.|:||...:|::|
Zfish   504 MEIAGQVKVDE---DPVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVS 565

  Fly  1251 QETRDRL----DARGGYAIEPRGLIDIKGKGMMNTFWLLGKK 1288
            :.|...|    :|...:.:|.||.:.:|||......|.|.:|
Zfish   566 EYTYRCLQSVENADPQFHLEYRGPVTMKGKKEPMKVWFLSRK 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	8/36 (22%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	89/203 (44%)
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:285002
		HNOBA	207..406	CDD:285003	28/95 (29%)
		CYCc	385..584	CDD:214485	89/202 (44%)
		Guanylate_cyc	412..605	CDD:278633	84/196 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810