DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34357 and adcy8

DIOPT Version :9

Sequence 1:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	391	Identity:	114/391 - (29%)
Similarity:	174/391 - (44%)	Gaps:	76/391 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1028 FNSVYERFKMLNHGRKVNFVDT---------MF--------QMLEKYSNNLEELIR----ERTEQ 1071
            :..::.|:..|...:..:|:.|         ||        |.|| |:..|:.|.|    |...:
Zfish   851 YTPLFIRYDTLTLNQSKSFLGTKETSLLLMAMFLLAVFYHGQQLE-YTARLDFLWRVQAKEEINE 914

  Fly  1072 LDIERKKTEQLLNRMLPSSVA----EKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHC----SP 1128
            :...|:..|.:|..:|||.||    ||.:....:..:.:..|.:.|:.|.||....:..    ..
Zfish   915 MRELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQG 979

  Fly  1129 VQVVDLLNDLYTIFDATINA---YNVYKVETIGDAYMVVSGL-PVKIP-----DHAEQIATMALD 1184
            |:.:.|||::...||..:..   .::.|::|||..||.|||| |.|..     .|...:|..|:.
Zfish   980 VECLRLLNEIIADFDELLGEERFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFAIA 1044

  Fly  1185 LLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHM 1249
            |.......| ||... ..|||||:..|...|||:|...|:|.::|.|||.||||:|||.|.:|.:
Zfish  1045 LNESIQEIN-KHSFN-NFQLRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQL 1107

  Fly  1250 SQETRDRLDARGGYAIEPRGLIDIKG----KGMMNTFWLLGKKGFDKPLPAPPPIGESH------ 1304
            .:||...|:.| |:|.|.||.|.:||    :|.:.|.:::|:...:..:..|..:...:
Zfish  1108 PEETYAILNER-GFAFEYRGEIYVKGISEQEGKIRTHFMIGRVQPNPLILQPRKLTGQYSLAAVV 1171

  Fly  1305 -GLDESLIR-----------NSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEITPPTNADL 1357
             ||.:||.|           ||..:|...|: ||...|..|.:|         ..|:|  ..:||
Zfish  1172 LGLVQSLNRQKQKQILNENNNSGIMKGHYNR-RTLLAPGGSDTS---------HAEVT--DKSDL 1224

  Fly  1358 A 1358
            |
Zfish  1225 A 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	2/12 (17%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	71/208 (34%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831
		CYCc	340..538	CDD:214485
		Guanylate_cyc	379..563	CDD:278633
		DUF1053	592..685	CDD:283888
		CYCc	919..1123	CDD:214485	71/206 (34%)
		Guanylate_cyc	948..1147	CDD:278633	69/201 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910