Protein Alignment SLO2 and Kcnma1

DIOPT Version :9

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: NP_114016.2
• Gene: Kcnma1 / 83731
• RGDID: 620715
• Length: 1242
• Species: Rattus norvegicus
• Alignment Length: 1450
• Identity: 268/1450 - (18%)
• Similarity: 446/1450 - (30%)
• Gaps: 555/1450 - (38%)

  Fly   214 LTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLN-CWLAKRSLENMFNDLH 277
            |.::.....:|       |.||:.:.:.| .|:  ||   :|:.::|| .||..|.|
  Rat   231 LRFIAANDKLW-------FWLEVNSVVDF-FTV--PP---VFVSVYLNRSWLGLRFL-------- 274

  Fly   278 RAMQKSQ-SALSQQLTIL---------------------SATLLCLVFTSVCGIQHFQRAGHRHL 320
            ||::..| |.:.|.|.||                     :|..:.||..|....::||  .::.|
  Rat   275 RALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQ--NNQAL 337

  Fly   321 NLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYS 385
            ..::..|.::||.|||||||........:|:||..|...|.:..:...::......|:|.|||||
  Rat   338 TYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYS 402

  Fly   386 SHRAQSEKHVVVCS-TTLHADTIMDFLNEFYAHPLLQDFYVVL-----LSP-MELDTTM-RMILQ 442
            :  ....||:|||. .||  :::.:||.:| .|....|..|.:     :|| :||:... |...|
  Rat   403 A--VSGRKHIVVCGHITL--ESVSNFLKDF-LHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQ 462

  Fly   443 VPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVP 507
            |.       :.|||.|...||||.::..|:||.|||.:..||..|.|...|:|..::|::.|.:.
  Rat   463 VE-------FYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIR 520

  Fly   508 QYVQIFRPEHKLHV--------KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQ 564
            ...|:.:..:|.|:        |..:..:|..|.|...:|.:|...|.||::..|.  |.....:
  Rat   521 IITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLF--SMRSFIK 583

  Fly   565 QSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHS-----HRKYGVALVGV--RPA 622
            ...:.|.:.|.:...||:|          .||...:|...||.:     ..|..:.::.:  :.|
  Rat   584 IEEDTWQKYYLEGVSNEMY----------TEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSA 638

  Fly   623 ELPEFYEETILLNPGPRHIMKKDDTC--YYMSITKEENSAFV---VNQNQTSDPTAAAKEGSGTG 682
            .......:.||:||| .|:..::.|.  :..|..||...||.   ...:..:||....|.|....
  Rat   639 NRESRSRKRILINPG-NHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRL 702

  Fly   683 GGGGAS-----SSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTA 742
            .....|     |.|.......:....:.::..|:....|:...|..|::        ::|..||:
  Rat   703 IYSKMSIYKRMSRACCFDCGRSERDCSCMSGRVRGNVDTLERNFPLSSV--------SVNDCSTS 759

  Fly   743 AAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSEN 807
            ..|                                     :....||
  Rat   760 FRA-------------------------------------FEDEQPP------------------ 769

  Fly   808 PTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTS 872
                                        ||        ||.....:||
  Rat   770 ----------------------------TL--------SPKKKQRNGG----------------- 781

  Fly   873 LSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEG 937
                              ..|:|| .||.::.     ..|.::|             |||..:..
  Rat   782 ------------------MRNSPN-TSPKLMR-----HDPLLIP-------------GNDQIDNM 809

  Fly   938 DESDDEIDDE--MPWRSPSE-----------KIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCS 989
            |.:..:.|..  ..|.:|.|           .:..|.||        :::          |.|
  Rat   810 DSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGH--------VVV----------CIF-- 854

  Fly   990 ATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRV-------MK 1047
              ...|:|.:.:.....|..|                       |..:..:|:..|       :|
  Rat   855 --GDVSSALIGLRNLVMPLRA-----------------------SNFHYHELKHIVFVGSIEYLK 894

  Fly  1048 KSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAM 1112
            :.:   ....:.|.:.:       |.|..|:|...|...:..|..|                ..:
  Rat   895 REW---ETLHNFPKVSI-------LPGTPLSRADLRAVNINLCDMC----------------VIL 933

  Fly  1113 AAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLA 1177
            :|.......||              :.|..||:...
  Rat   934 SANQNNIDDTS--------------LQDKECILASL----------------------------- 955

  Fly  1178 QVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFL 1242
                     |.|..|:.:...:|.|:  |.|   |..|  ...||....:|:..:| |:|.:.
  Rat   956 ---------NIKSMQFDDSIGVLQAN--SQG---FTPP--GMDRSSPDNSPVHGML-RQPSIT-- 1001

  Fly  1243 DALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFF 1307
                                    .|:
  Rat  1002 ------------------------TGV-------------------------------------- 1004

  Fly  1308 PSIKSITELSQSSNMRFMQFRAHD--KYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASML 1370
             :|..||||...:|::|:.....|  ...|:|::                  |||.|..|:.|:|
  Rat  1005 -NIPIITELVNDTNVQFLDQDDDDDPDTELYLTQ------------------PFACGTAFAVSVL 1050

  Fly  1371 DTLLYQAFVKDYVITFVR------------LLLGIDQAPGSGFLTSMRITKDDMWIRT------- 1416
            |:|:...:..|.::|.:|            .|:..:.|...|:.|...:...|. .|.
  Rat  1051 DSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR-CRVAQLALLD 1114

  Fly  1417 -----------YGRLYQKLCSTTCEIPIGIYRTQDTSNADTSH------VSNSPVERWGPFSAFS 1464
                       ||.|:.|...|...:..||||.:|...:..|.      ::|.|.|    |....
  Rat  1115 GPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYE----FELVP 1175

  Fly  1465 RHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERK 1529
            ...:.....:|...|                 :...|.:..:.|.:...::..||:.:...:.|.
  Rat  1176 TDLIFCLMQFDHNAG-----------------QSRASLSHSSHSSQSSSKKSSSVHSIPSTANRP 1223

  Fly  1530 GSSYSINLADEARDNHAQQI 1549
            ....|    .|:||...:::
  Rat  1224 NRPKS----RESRDKQKKEM 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	21/65 (32%)
		BK_channel_a	524..619	CDD:281490	21/99 (21%)
Kcnma1	NP_114016.2	PLN03192	217..>393	CDD:215625	46/184 (25%)
		PRK10537	<343..>415	CDD:236711	27/73 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840