Protein Alignment SLO2 and kcnma1b

DIOPT Version :9

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_021336127.1
• Gene: kcnma1b / 798583
• ZFINID: ZDB-GENE-101209-2
• Length: 1107
• Species: Danio rerio
• Alignment Length: 1585
• Identity: 302/1585 - (19%)
• Similarity: 467/1585 - (29%)
• Gaps: 658/1585 - (41%)

  Fly   115 IKNQRSSLRIRIADLF-LKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQE 178
            |..|..:.|:.:..:| |.:.:.|:|.|    |.:....:|                   |.|.:
Zfish    12 ISAQTLTGRVLVVLVFALSIGALVIYFI----DSSDPIESC-------------------EHFDK 53

  Fly   179 NPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYK-----GNIWQQILSFHFILELVT 238
            |                 :.||:.:|.    ....|.|.|.:     ..:|       |.||:.:
Zfish    54 N-----------------FTLQIDMAF----NVFFLLYFGLRFIAANDKLW-------FWLEVNS 90

  Fly   239 TIPFALTIVHPPLRNLFIPIFLN-CWLAKRSLENMFNDLHRAMQKSQ-SALSQQLTILSAT---- 297
            .:.| .|:  ||   :|:.::|| .||..|.|        ||::..| |.:.|.|.||..:
Zfish    91 VVDF-FTV--PP---VFVSVYLNRSWLGLRFL--------RALRLIQFSEILQFLNILKTSNSIK 141

  Fly   298 --LLCLVFTS----VCGIQH-----------FQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDI 345
              .||.:|.|    ..|..|           ||.:  :.|:.::..|.::||.|||||||.....
Zfish   142 LVNLCSIFISTWLTAAGFIHLVENSGDPWENFQNS--QPLSYWECVYLLMVTMSTVGYGDVCAKT 204

  Fly   346 WPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCS-TTLHADTIMD 409
            ...:|:||..|...|.:..:...::......|:|.|||||:  ....||:|||. .||  :::.:
Zfish   205 TLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSA--VNGRKHIVVCGHITL--ESVSN 265

  Fly   410 FLNEFYAHPLLQDFYVVL-----LSP-MELDTTM-RMILQVPIWAQRVIYIQGSCLKDGDLARAR 467
            ||.:| .|....|..|.:     :|| :||:... |...||.       :.|||.|...||||.:
Zfish   266 FLKDF-LHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVE-------FYQGSVLNPHDLARVK 322

  Fly   468 MNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHV--------KFA 524
            :..|:||.|||.:..||..|.|...|:|..::|::.|.:....|:.:..:|.|:        |..
Zfish   323 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEG 387

  Fly   525 EHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGD 589
            :..:|..|.|...:|.:|...|.||::..|.  |.....:...:.|.:.|.:...||:|
Zfish   388 DDAICLAELKLGFIAQSCLAQGLSTMLANLF--SMRSYIKIEEDTWQKYYLEGVANEMY------ 444

  Fly   590 SRFFGEYEGKSFTYASFHS-----HRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTC- 648
                .||...:|...||.:     :.|..:.|:.:....  :..|.:.|:||| .|:..::.|.
Zfish   445 ----TEYLSSAFVGLSFPTVCELCYVKLKLLLIAIEYKS--DQRESSTLINPG-NHVKMQEGTLG 502

  Fly   649 -YYMSITKEENSAFV---VNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTT 709
             :..|..||...|..   ...:..:||....|.|
Zfish   503 FFIASDAKEVKRALFYCKACHDDITDPKRIKKCG------------------------------- 536

  Fly   710 VQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHL 774
                                                       |.|:.:|.|..:|
Zfish   537 -------------------------------------------CKRMLYSKSNYNG--------- 549

  Fly   775 QPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPP 839
                                       ::.|       |:|..|                   .|
Zfish   550 ---------------------------YIKS-------IADESQ-------------------CP 561

  Fly   840 PPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLN 904
            .|....|.                                         ||.|..|    ..::|
Zfish   562 RPAVRSSA-----------------------------------------VPAARVP----VPLVN 581

  Fly   905 QRRGS-----RRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDE-----------MPWRSP 953
            .|:||     ....:|..|........|:|.:   .|...|.:.:|||           :..|.|
Zfish   582 YRKGSTLSADHHKGLLLSPAASYLHRLSLASS---RELQRSREGVDDEGVRLHRACSLPVKHRHP 643

  Fly   954 SEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSD 1018
            |              |:||::...:.|            |.|                    |..
Zfish   644 S--------------THSLLVEEEQHS------------SLS--------------------PKK 662

  Fly  1019 SAGESGTNADSAAMPSE--EYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLA 1081
            .....|........|..  .:.|.|....|      |...:.....||
Zfish   663 KQRNGGMRTSPTCSPKNLIRHDPLLEMETM------DENIKKYDSTGM----------------- 704

  Fly  1082 ARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVK 1146
                 ...|.|........|.:.|     ||...||....
Zfish   705 -----FHWCPSKDIERVLLTRSEA-----AMTVLSGHVVV------------------------- 734

  Fly  1147 GFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYN 1211
                                                |.:.:.|.              |..|:.|
Zfish   735 ------------------------------------CIFGDVKS--------------ALIGLRN 749

  Fly  1212 FIIPLRA---HFRSKTSLNPIILLLERRPDVAFLDALSY----------FPLVYWMLGSIDCLDD 1263
            .::||||   |:.   .|.||:          |:.:|.|          ||.|..:.|:.....|
Zfish   750 LVMPLRASNFHYH---ELKPIV----------FVGSLEYLKREWETLHNFPKVSILPGTPLSRAD 801

  Fly  1264 LLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFK----------------FFP---- 1308
            |....|.|.:..|:::.. .|:.::.||.|...|:|..|:..                |.|
Zfish   802 LRAVNINLCDMCVILSAN-QNNIDDASLQDKECILASLNIKSMQFDDSIGLLQANSQGFTPPGMD 865

  Fly  1309 ----------------------SIKSITELSQSSNMRFMQFRAHD--KYALHLSKMEKREKERGS 1349
                                  :|..||||...||::|:.....|  ...|:|::
Zfish   866 RSSPENSPVHGLVRQASITTGANIPIITELVNDSNVQFLDQDDDDDPDTELYLTQ---------- 920

  Fly  1350 HISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRL------------LLGIDQAPGSGFL 1402
                    |||.|..|:.|:||:|:...:..|.::|.:|.            ||..:.|...|:.
Zfish   921 --------PFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEGLLAEENALRGGYS 977

  Fly  1403 TSMRITKDDMWIRT------------------YGRLYQKLCSTTCEIPIGIYRTQDTSNADTS-- 1447
            |...:...|. .|.                  ||.|:.|...|...:..||||.:|......|
Zfish   978 TPQTLANRDR-CRVAQLALYDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLTAASLC 1041

  Fly  1448 ----HVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASS 1508
                .::|.|.|    |.......:.....:|...|...|..::                  .||
Zfish  1042 TKRYVITNPPYE----FDLVPTDLIFCLMQFDHNAGQSRSNLNT------------------QSS 1084

  Fly  1509 FRPQPQRQRSVNCLGGCSERKGSSY 1533
            |.|..:..||     .|:.|....|
Zfish  1085 FCPVRRASRS-----RCTPRDKQKY 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	24/86 (28%)
		BK_channel_a	524..619	CDD:281490	22/99 (22%)
kcnma1b	XP_021336127.1	Ion_trans	21..238	CDD:306908	64/283 (23%)
		NADB_Rossmann	252..365	CDD:328723	40/122 (33%)
		BK_channel_a	387..475	CDD:308870	22/99 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587085
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840