Protein Alignment SLO2 and kcnt2l

DIOPT Version :10

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_012808571.1
• Gene: kcnt2l / 779818
• XenbaseID: XB-GENE-5993003
• Length: 1159
• Species: Xenopus tropicalis
• Alignment Length: 1565
• Identity: 629/1565 - (40%)
• Similarity: 836/1565 - (53%)
• Gaps: 463/1565 - (29%)

  Fly    83 DISRSSMRLDERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDK 147
            |:.....:.|:||.||:|||||:|||||:|:||||||||||:|:.:..||||||:||||||:||
 Frog    18 DLLMGDWQQDDRVHVEFYVNENSFKERLKLFFIKNQRSSLRVRVFNCSLKLLSCLLYIIRVLLD- 81

  Fly   148 NPTFIT--CYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQ 210
            :|....  |:.|              |::.:......:|..|:|||||..||.||:|:|::|..:
 Frog    82 DPRESRGGCWEC--------------TKQNYSAQQKFDWTPIIWVNRPLPLWGLQVLVALISFWE 132

  Fly   211 SLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFND 275
            :::|||||||||||:|:|...||||::.|:||.:||..|||||:|||:||||||||.:||||.||
 Frog   133 TMLLTYLGYKGNIWEQLLRIPFILEMLNTLPFFVTIFWPPLRNVFIPVFLNCWLAKHALENMIND 197

  Fly   276 LHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGD 340
            ||||:|::.||:..|:.||..||:||:||.:|||||.:|||: :|.||.|.|:.:|||||||:||
 Frog   198 LHRAIQRTHSAMFNQVFILICTLICLMFTCICGIQHLERAGN-NLTLFDSLYFCIVTFSTVGFGD 261

  Fly   341 FVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHAD 405
            ..|.||||||.:||||||||||||.|||||.|.||||||.||:||.:|||:|||||:|.::|..|
 Frog   262 VTPKIWPSQLLVVIMICVALIVLPIQFEQLVFLWMERQKSGGNYSRYRAQTEKHVVLCVSSLKID 326

  Fly   406 TIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNE 470
            .:|||||||||||.|||.|||||.|.|:|..:|.:||:|:|:|||||:|||.|||.||.||::::
 Frog   327 LLMDFLNEFYAHPRLQDHYVVLLCPTEMDLPVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKIDD 391

  Fly   471 AEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKY 535
            |||||||:.|...|:.|||..||||:|||||||||.|.||||.:||:|.|:|||:|||||:||||
 Frog   392 AEACFILSNRFERDRIAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKY 456

  Fly   536 ALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKS 600
            |:||.||.||..|||:|||:||||||:...||::|...|.:||.||:|||.|.:|:|||||||||
 Frog   457 AMLALNCVCPATSTLITLLIHTSRGQDSASSPDQWQNTYSRCSANEVYHIRLSESKFFGEYEGKS 521

  Fly   601 FTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQ 665
            |||:|||:|:||||.|:|||...     :.:|||||||.|||...|||:|::|:|||||||.:..
 Frog   522 FTYSSFHAHKKYGVCLIGVRRDN-----KTSILLNPGPCHIMSSTDTCFYINISKEENSAFSLKD 581

  Fly   666 NQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSAS 730
            |:.:..:...|                                          :|:...|.|
 Frog   582 NEEAKKSGYPK------------------------------------------STYHGLTRL--- 601

  Fly   731 TTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDS 795
                             ||.|:
 Frog   602 -----------------PVHSI------------------------------------------- 606

  Fly   796 GEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGG 860
                   :.|....|:.:..||                            ||....|
 Frog   607 -------IASMGTVAMDLQGSR----------------------------SPESVDG-------- 628

  Fly   861 LGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSP--DVLNQRRGSRRPSILPVPDMFTS 923
                                               |:|||  |..:.|:.| ..::|.|.|..||
 Frog   629 -----------------------------------NMLSPPADGTHTRKHS-IDAVLDVVDGDTS 657

  Fly   924 SSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFC 988
            ::|.:..:...:|..:||:|:|
 Frog   658 TNFDLLSDQSEDETSQSDEELD------------------------------------------- 679

  Fly   989 SATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCD 1053
                                                                             
 Frog   680 ----------------------------------------------------------------- 679

  Fly  1054 SECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGA 1118
                                                                             
 Frog   680 ----------------------------------------------------------------- 679

  Fly  1119 TAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHC 1183
                  ||:.               :|||:|..:|:||.|||||:||::|.|.|||:|.:.|:|.
 Frog   680 ------SSIN---------------LVKGYPSNTPYIGSSPTLCHLLQQKNPYCCLRLDKSCQHY 723

  Fly  1184 SYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYF 1248
            .|.:|:.|.::|..:|::|::|.||:||||:||||::|.|..|:|||||||..|||.||:|:.:|
 Frog   724 PYEDARAYGFRNALVIVSAEHAGNGLYNFIVPLRAYYRGKKELSPIILLLENPPDVQFLEAICWF 788

  Fly  1249 PLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSI 1313
            ||||:|:||||.|||:||.|::.|..:|||.:|.|..||||.::|..|||.||.:|:.||.:..|
 Frog   789 PLVYYMVGSIDNLDDMLRCGVSYAAHMVVVGEESSMIAEEDYMADARTIVNVQTLFRLFPGLNII 853

  Fly  1314 TELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAF 1378
            |||:..:|||||||:|.|||::.|||:||||:||||::.:|||||||||.|||.|||||||||:|
 Frog   854 TELTHPANMRFMQFKAKDKYSVVLSKLEKRERERGSNLVFMFRLPFAAGKVFSVSMLDTLLYQSF 918

  Fly  1379 VKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQ-DTS 1442
            ||||:|:..|||||:|..||||||.::|:|::|:|||.||||||||||||.:||||||||: ...
 Frog   919 VKDYMISITRLLLGLDSMPGSGFLCALRVTEEDLWIRCYGRLYQKLCSTTGDIPIGIYRTETHLL 983

  Fly  1443 NADTSHVSNSPVE--------RWGPFSAFSRHCVRLRPSYDEETGTP----DSTKDSTE--MLRG 1493
            .|..|.||.| ||        |||                |...|.|    .::.|.:|  :||
 Frog   984 PASESQVSIS-VEDYEDTRETRWG----------------DPSQGRPLHRNSTSSDQSEHPLLR- 1030

  Fly  1494 VTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLV 1558
                            |...|..|.::..|.....|.:|..|:   :.|.:..::.||.|:..||
 Frog  1031 ----------------RKSMQWARRLSRKGARQPGKSASERIS---QQRMSLYRRSERQELNALV 1076

  Fly  1559 RSRMESLNLPTIDYD----DVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHN 1619
            ::||:.|.|.|.:|.    |:.:..|.|||::||||.|.|||..|::||:||.|.    |.....
 Frog  1077 KTRMKHLGLSTAEYSMKQMDIMDTDNTLSYILINPSPDTKLELNDVVYLIRPDPL----TLVSMK 1137

  Fly  1620 SRRKS 1624
            ||:.|
 Frog  1138 SRKAS 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	30/43 (70%)
		BK_channel_a	525..619	CDD:460947	62/93 (67%)
kcnt2l	XP_012808571.1	Ion_trans	<134..284	CDD:459842	98/150 (65%)
		Ion_trans_2	220..286	CDD:462301	45/66 (68%)
		BK_channel_a	446..540	CDD:460947	62/93 (67%)