DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and Kcnu1

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	XP_017455870.1	Gene:	Kcnu1 / 680912	RGDID:	1585877	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	1598	Identity:	267/1598 - (16%)
Similarity:	472/1598 - (29%)	Gaps:	676/1598 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQEN 179
            |:.|.:.:...:|..|..|:  ||:|.|:.|..:..:.|..|...       |....:....:.|
  Rat    21 IEIQAAFILSSLATFFGGLI--VLFIFRIALKISRNWKTVKGPRG-------ILELFSSRRIEVN 76

  Fly   180 PI--INWDAI------LWVNRPTVLWVLQLLLAMVSLTQSLVLTYL----------GYKGNIWQQ 226
            |:  :.:..:      :.::..|::..:.::|..|....|||:.::          .|:..|...
  Rat    77 PLRKLYFHGVFRERIEMLLSAQTIVGQVLVILVFVLSIGSLVIYFINSMDPVRKCSSYEDKIVHV 141

  Fly   227 ILSFH-------------------FILELVTTIPFALTIVHPPLRNLFIPIFLNC-WLAKRSLEN 271
            .|||:                   |.||: .:|....||  ||   .||..:|.. ||..|.|..
  Rat   142 DLSFNAFFSFYFGLRFWAAEDKIKFWLEM-NSIVDIFTI--PP---TFISYYLKSNWLGLRFLRA 200

  Fly   272 M----FNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHF-----------QRAGHRHLN 321
            :    ...:.:.:|..:::.|.:|:.|.:.::...||: .|..|.           :.:|...||
  Rat   201 LRLLELPKILQILQVIKTSNSVKLSKLMSIVISTWFTA-AGFLHLTFPLPSLFGQVENSGDPWLN 264

  Fly   322 --------LFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQ 378
                    .|:|.|.|..|.||||:||.|......::::|.....:||:......::...:..|:
  Rat   265 GRNSQTMSYFESIYLVTATMSTVGFGDVVAKTSLGRIFIVFFTLGSLILFANYIPEMVELFSTRK 329

  Fly   379 KLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQ-DFYVVLLS----PMELDTTMR 438
            |....|.:  .:.:|.:|||. .:..|::..||..|......: :..:|.|.    .:||:|.::
  Rat   330 KYNKPYEA--VKGKKFIVVCG-NITIDSVTAFLRNFLHRKAGEINIEIVFLGEAPPSVELETLLK 391

  Fly   439 MILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFA 503
                  .......::.|:.||..||.|..:..||||.|||....:|....|...|:|..::|::.
  Rat   392 ------CHTSCTTFVCGTALKFEDLKRVAVENAEACLILANPFCSDLHDEDNSNIMRVLSIKNYY 450

  Fly   504 PNVPQYVQIFRPEHKLHV--------KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRG 560
            |.....:|:.:.::|:.:        ...::::|..|.|...:|..|..||..|.:|.|......
  Rat   451 PQTRVIIQMLQSQNKVFLSRIPNWNWSAGDNIICFAELKLGFIAQGCLVPGLCTFLTTLFIEQNQ 515

  Fly   561 QEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELP 625
            :...:.|.:.|.|.|  ..|:|.     ..|...::.|.:|...|.....|..:.|:.::  ..|
  Rat   516 KVFPKHPWQKHFLNG--LKNKIL-----TQRLSNDFVGMTFPQVSRLCFLKMHLMLIAIQ--HKP 571

  Fly   626 EFYE-ETILLNPGPRHIMKKDDTCYYMS-ITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGAS 688
            .|:. .:::|||..:..:.||...:::: .:|:...|.....|..||
  Rat   572 LFHNCCSLILNPSSQVRLNKDTLGFFIAESSKDVKRALFYCSNCHSD------------------ 618

  Fly   689 SSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVC 753
                                                                           ||
  Rat   619 ---------------------------------------------------------------VC 620

  Fly   754 VRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQ 818
                                                                 ||..:
  Rat   621 -----------------------------------------------------NPELI------- 625

  Fly   819 NLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTT 883
                                             |..||..
  Rat   626 ---------------------------------GKCGCKN------------------------- 632

  Fly   884 GNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEM 948
                    .:...|::|.::..:  |......|..:::||.|
  Rat   633 --------RSRQQLVAPTIMVMQ--SSLNEFAPTAEIYTSIS----------------------- 664

  Fly   949 PWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAP 1013
                             :.:|.|:.:.::.:
  Rat   665 -----------------REQTSSVTILTTRN---------------------------------- 678

  Fly  1014 AYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLA 1078
             .|.|:|.:|.. .||:.|                    ...|||:|                |.
  Rat   679 -MPVDTADDSDM-LDSSGM--------------------FHWCRSMP----------------LD 705

  Fly  1079 RLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSC 1143
            ::..:|                              ...||
  Rat   706 KVVLKR------------------------------SDKAT------------------------ 716

  Fly  1144 IVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILA---ADYA 1205
                                                           :::||..:...   |..:
  Rat   717 -----------------------------------------------HEFQNHIVACVFGDAHSS 734

  Fly  1206 SNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSY----------FPLVYWMLGSIDC 1260
            ..|:.||::||||...::..|.          |:.|:.:|.|          ||.::.|.||...
  Rat   735 LMGLRNFVMPLRASNYTRQELK----------DIVFIGSLEYFQREWRFLRNFPKIHIMPGSALY 789

  Fly  1261 LDDLLRAGITLAESVVVV---NKELSNSAEEDSLSDCNTIVAVQNM------------------- 1303
            ..||....:......|::   .|.||:..    |.|..||:|..|:
  Rat   790 TGDLHAVNVEQCSMCVILATPYKALSSQL----LVDTETIMATLNIQALRISCPMSGSSKKEVNT 850

  Fly  1304 ----FKF-----FPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPF 1359
                .|:     :..|..:|||...||:.|::         .:..:::..|....|:|    ..|
  Rat   851 SPTFSKYEGKQRYQQIPILTELKNPSNIHFIE---------QMDGLDEAIKGTSLHLS----TAF 902

  Fly  1360 AAGAVFSASMLDTLLYQAFVKDYVITFVRLLL--GIDQAP---------------GSGFLTSM-- 1405
            :.|.|||.:.||:||..||...:|:..:::|:  ||:...               |:.||:..
  Rat   903 STGTVFSGTFLDSLLATAFYNYHVLELLQMLVTGGINSQTEHCLVKEKLYEGNEGGATFLSGRTR 967

  Fly  1406 ----------RITKDDMWIRTYGRLYQKLCSTTCEIPI---GIYRTQD-------------TSNA 1444
                      .|..|....:|:|:|:   |.:...:.|   |:||..|             |..|
  Rat   968 CKLGLLSLDETILSDIKPKKTFGQLF---CGSLDNLGILCVGLYRMMDEGEHNSERKRFVITRPA 1029

  Fly  1445 DTSHVSNSPVERWGPFSA--FSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGAS 1507
            :..|:..|.:    .|.|  ||..|.:      .|:......:|:|   ..||....||...||.
  Rat  1030 NECHLLPSDL----VFCAIPFSITCDK------SESNASIQDQDTT---TNVTSMSQGSNFQGAQ 1081

  Fly  1508 SFRPQPQRQRSVNCLGGCSERKGSS------YSINLAD 1539
            |    ...:.|::......|:|...      |.:||.|
  Rat  1082 S----ALNEHSLSPASAMGEKKSPQLLNSRVYPLNLFD 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	22/84 (26%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	22/94 (23%)
Kcnu1	XP_017455870.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D858812at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850