Protein Alignment SLO2 and Kcnt1

DIOPT Version :10

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_006233759.1
• Gene: Kcnt1 / 60444
• RGDID: 621106
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 1616
• Identity: 658/1616 - (40%)
• Similarity: 863/1616 - (53%)
• Gaps: 469/1616 - (29%)

  Fly    79 SVWSDISR----SSMRLD---ERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSC 136
            ||.||:.:    ....||   .:|:||:|||||||||||:|:||||||||||||:.:..||||:|
  Rat    44 SVGSDVGQRLHVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTC 108

  Fly   137 VLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQL 201
            :|||:||:||.....|.|:||     |::..:...:..||      :|..||||.|...|||:|:
  Rat   109 LLYIVRVLLDNPDQGIGCWGC-----TKYNYTFNGSSSEF------HWAPILWVERKMALWVIQV 162

  Fly   202 LLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAK 266
            ::|.:|..::::|.||.||||||:||....|:||::.|:||.:|:..|||||||||:||||||||
  Rat   163 IVATISFLETMLLIYLSYKGNIWEQIFHVSFVLEMINTLPFIITVFWPPLRNLFIPVFLNCWLAK 227

  Fly   267 RSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVV 331
            .:||||.||.|||:.::|||:..|:.||..||||||||..|||||.:||| .:|||..|.|:.:|
  Rat   228 HALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAG-GNLNLLTSFYFCIV 291

  Fly   332 TFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVV 396
            ||||||:||..|.||||||.:||:|||.|:|||.|||:|.:.||||||.||:||.|||::|||||
  Rat   292 TFSTVGFGDVTPKIWPSQLLVVILICVTLVVLPLQFEELVYLWMERQKSGGNYSRHRARTEKHVV 356

  Fly   397 VCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDG 461
            :|.::|..|.:|||||||||||.|||:|||:|.|.|:|..:|.:||:|:|:|||||:|||.|||.
  Rat   357 LCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPSEMDVQVRRVLQIPLWSQRVIYLQGSALKDQ 421

  Fly   462 DLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEH 526
            ||.||:|:..||||||::||..|:||||..||||:|||||||||.|.||||.:||:|.|||||:|
  Rat   422 DLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADH 486

  Fly   527 VVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSR 591
            ||||:|.|||:||.||.||..|||:|||:|||||||||:|||:|.|:||:|||||:|||.:|||:
  Rat   487 VVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSK 551

  Fly   592 FFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKE 656
            ||.||||||||||:||:|:||||.|:|::..|     .::||||||||||:...|||:|::||||
  Rat   552 FFREYEGKSFTYAAFHAHKKYGVCLIGLKREE-----NKSILLNPGPRHILAASDTCFYINITKE 611

  Fly   657 ENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTF 721
            |||||:..|.:.......|.:....|
  Rat   612 ENSAFIFKQEEKQKRRGLAGQALYEG--------------------------------------- 637

  Fly   722 TSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQP 786
                                                                             
  Rat   638 ----------------------------------------------------------------- 637

  Fly   787 HPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAG 851
                             ||..|...||:         ::...|..:..|...|         ..|
  Rat   638 -----------------PSRLPVHSIIA---------SMGTVAMDLQNTDCRP---------SQG 667

  Fly   852 GSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILP 916
            |||| |||.|.|                          |..|.            .|||||||.|
  Rat   668 GSGG-GGGKLTL--------------------------PTENG------------SGSRRPSIAP 693

  Fly   917 VPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSY 981
            |.::..||:.                              :.|           .|:...|||.
  Rat   694 VLELADSSAL------------------------------LPC-----------DLLSDQSEDE- 716

  Fly   982 QRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVM 1046
                                            ..|||..|.|
  Rat   717 --------------------------------VTPSDDEGLS----------------------- 726

  Fly  1047 KKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTA 1111
                                                                             
  Rat   727 ----------------------------------------------------------------- 726

  Fly  1112 MAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQL 1176
                                      |.:|   |||:||.||:||.|||||:||..|.|.|||:|
  Rat   727 --------------------------VVEY---VKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRL 762

  Fly  1177 AQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAF 1241
            .:.|:|.||.:||.|.::||.||::|:.|.||:||||:||||::||:..||||:|||:.:||..|
  Rat   763 DKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRRELNPIVLLLDNKPDHHF 827

  Fly  1242 LDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKF 1306
            |:|:..||:||:|.||:|.||.||:.||..|:::|||:||.:.|||||.::|..|||.||.||:.
  Rat   828 LEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRL 892

  Fly  1307 FPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLD 1371
            |||:...|||:..||||||||||.|.|:|.|||:||:|:|.||::::|||||||||.|||.||||
  Rat   893 FPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKQERENGSNLAFMFRLPFAAGRVFSISMLD 957

  Fly  1372 TLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIY 1436
            |||||:|||||:||..|||||:|..||||:|.:|::|:||:||||||||:|||||::.|||||||
  Rat   958 TLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKVTEDDLWIRTYGRLFQKLCSSSAEIPIGIY 1022

  Fly  1437 RTQDTSNADTSHV-SNSPVE---RWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYR 1497
            ||:       .|| |:.|.:   :.||       .:.|.|:..:.:...:..:|:.| .:|
  Rat  1023 RTE-------CHVFSSEPHDLRAQGGP-------AIALLPAQSQISVNMEDCEDTRE-AKG---- 1068

  Fly  1498 PPG--SATGGAS-------SFRPQPQ---RQRSVNCLGGCSERKGSSYSINLADEARDNHAQQ-- 1548
            |.|  :|:||.|       |..|...   |::|:......|.:  ||.....|....|...||
  Rat  1069 PWGTRAASGGGSTHGRHGGSADPVEHPLLRRKSLQWARKLSRK--SSKQAGKAPMTTDWITQQRL 1131

  Fly  1549 -----IERAEIANLVRSRMESLNLPTIDYDDVS----------------------EKRNHLSYVI 1586
                 .||.|::.||::||:.|.|||..|:||:                      ..:|.||||:
  Rat  1132 SLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHHQNTLSYVL 1196

  Fly  1587 INPSCDLKLEEGDLIYLVRPSPFSAQKTFERH-NSRRKSNISFCSNINLGATCGPQ 1641
            |||..|.:||..|::||:|..|.:       | .|..:|..|.||| .| ::|.|:
  Rat  1197 INPPPDTRLEPNDIVYLIRSDPLA-------HVTSSSQSRKSSCSN-KL-SSCNPE 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	27/43 (63%)
		BK_channel_a	525..619	CDD:460947	68/93 (73%)
Kcnt1	XP_006233759.1	Ion_trans	143..323	CDD:459842	106/186 (57%)
		Ion_trans_2	258..331	CDD:462301	49/73 (67%)
		BK_channel_a	485..579	CDD:460947	68/93 (73%)