DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and KCNT1

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	XP_011517179.1	Gene:	KCNT1 / 57582	HGNCID:	18865	Length:	1301	Species:	Homo sapiens

Alignment Length:	1642	Identity:	662/1642 - (40%)
Similarity:	871/1642 - (53%)	Gaps:	485/1642 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LNDLAGY-----PPQQLPTAPAVRRFSKSIFQRPRSMSVWSDISRSSMRLDERVRVEYYVNENTF 106
            |.|.||:     ..:.||..|.. ||...:...|            |.:.|:||:||:|||||||
Human    91 LLDTAGFKMSDLDSEVLPLPPRY-RFRDLLLGDP------------SFQNDDRVQVEFYVNENTF 142

  Fly   107 KERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKL 171
            ||||:|:||||||||||||:.:..||||:|:|||:||:||.....|.|:||.   |..:..:...
Human   143 KERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCP---KQNYSFNDSS 204

  Fly   172 TEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILEL 236
            :|        |||..||||.|...||.:|:::|::|..::::|.||.||||||:||....|:||:
Human   205 SE--------INWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEM 261

  Fly   237 VTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCL 301
            :.|:||.:||..|||||||||:||||||||.:||||.||.|||:.::|||:..|:.||..|||||
Human   262 INTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCL 326

  Fly   302 VFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQ 366
            |||..|||||.:||| .:|:|..|.|:.:||||||||||..|.||||||.:||||||||:|||.|
Human   327 VFTGTCGIQHLERAG-ENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQ 390

  Fly   367 FEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPM 431
            ||:|.:.||||||.||:||.||||:|||||:|.::|..|.:|||||||||||.|||:|||:|.|.
Human   391 FEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPT 455

  Fly   432 ELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRS 496
            |:|..:|.:||:|:|:|||||:|||.|||.||.||:|:..||||||::||..|:||||..||||:
Human   456 EMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRA 520

  Fly   497 WAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQ 561
            |||||||||.|.||||.:||:|.|||||:|||||:|.|||:||.||.||..|||:|||:||||||
Human   521 WAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ 585

  Fly   562 EGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPE 626
            |||:|||:|.|:||:|||||:|||.:|||:||.||||||||||:||:|:||||.|:|::..:
Human   586 EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKRED--- 647

  Fly   627 FYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSA 691
              .::||||||||||:...|||:|::|||||||||:..|.:.....|.:.:|...|
Human   648 --NKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEG--------- 701

  Fly   692 SHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRV 756
                                                                .|..||.|:...:
Human   702 ----------------------------------------------------PARLPVHSIIASM 714

  Fly   757 PHSPSYDSGGGTT-----GTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDS 816
                      ||.     ||.|
Human   715 ----------GTVAMDLQGTEH------------------------------------------- 726

  Fly   817 RQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLT 881
                                         .|:.:||.||
Human   727 -----------------------------RPTQSGGGGG-------------------------- 736

  Fly   882 TTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDD 946
              |:.|.:|..|.            .|||||||.||.::..||:.
Human   737 --GSKLALPTENG------------SGSRRPSIAPVLELADSSAL-------------------- 767

  Fly   947 EMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAP 1011
                      :.|           .|:...|||.
Human   768 ----------LPC-----------DLLSDQSEDE------------------------------- 780

  Fly  1012 APAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGT 1076
              ..|||..|.|
Human   781 --VTPSDDEGLS----------------------------------------------------- 790

  Fly  1077 LARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDY 1141
                                                                         |.:|
Human   791 -------------------------------------------------------------VVEY 794

  Fly  1142 SCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYAS 1206
               |||:||.||:||.|||||:||..|.|.|||:|.:.|:|.||.:||.|.::||.||::|:.|.
Human   795 ---VKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAG 856

  Fly  1207 NGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITL 1271
            ||:||||:||||::||:..||||:|||:.:||..||:|:..||:||:|.||:|.||.||:.||..
Human   857 NGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIY 921

  Fly  1272 AESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALH 1336
            |:::|||:||.:.|||||.::|..|||.||.||:.|||:...|||:..||||||||||.|.|:|.
Human   922 ADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLA 986

  Fly  1337 LSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGF 1401
            |||:||||:|.||::::|||||||||.|||.|||||||||:|||||:||..|||||:|..||||:
Human   987 LSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGY 1051

  Fly  1402 LTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRH 1466
            |.:|:||:.|:||||||||:|||||::.|||||||||:       |||          ||....|
Human  1052 LCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTE-------SHV----------FSTSEPH 1099

  Fly  1467 CVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGS--ATGGASSFR------PQPQ---RQRSVN 1520
            .:|.:..........:.|::    ::|    |.||  .|||:|..|      |...   |::|:.
Human  1100 DLRAQSQISVNVEDCEDTRE----VKG----PWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQ 1156

  Fly  1521 CLGGCS----ERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDV------ 1575
            .....|    ::.|.:.:.....:.|.:..::.||.|::.||::||:.|.|||..|:||
Human  1157 WARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTAS 1221

  Fly  1576 ---------------SEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERH-NSRRKS 1624
                           ::.:|.||||:|||..|.:||..|::||:|..|.:       | .|..:|
Human  1222 DVMNRVNLGYLQDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLA-------HVASSSQS 1279

  Fly  1625 NISFCSNINLGATCGPQ 1641
            ..|.||: .| ::|.|:
Human  1280 RKSSCSH-KL-SSCNPE 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	45/65 (69%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	69/94 (73%)
KCNT1	XP_011517179.1	Ion_trans_2	322..395	CDD:285168	51/73 (70%)
KCNT1	XP_011517179.1	BK_channel_a	548..643	CDD:281490	69/94 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152600
Domainoid	1	1.000	509	1.000	Domainoid score	I323
eggNOG	1	0.900	-	-		E1_KOG3193
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11055
Inparanoid	1	1.050	1195	1.000	Inparanoid score	I191
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48024
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	1	1.000	-	-		FOG0002662
OrthoInspector	1	1.000	-	-		otm40313
orthoMCL	1	0.900	-	-		OOG6_103731
Panther	1	1.100	-	-	O	PTHR10027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3407
SonicParanoid	1	1.000	-	-		X1773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800