Protein Alignment SLO2 and kcnma1a

DIOPT Version :10

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_009305518.1
• Gene: kcnma1a / 568554
• ZFINID: ZDB-GENE-070202-9
• Length: 1302
• Species: Danio rerio
• Alignment Length: 1747
• Identity: 344/1747 - (19%)
• Similarity: 558/1747 - (31%)
• Gaps: 632/1747 - (36%)

  Fly    12 LAMSDDNQTCSYSMPSVASPSLNHRLQRNVNFNEDLNDLAGYPPQQLPTAPAVRRFSKSIFQRPR 76
            ||::|.|.  ||.       |.:.|:..|:|||::
Zfish     2 LAVADGNG--SYG-------SSSSRMSNNINFNKN------------------------------ 27

  Fly    77 SMSVWSDISRSSMRLDERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYII 141
                 .|.|.|..::|..:.....|..:...:|:...|:   .||:......||:.||...|..:
Zfish    28 -----PDSSVSISKMDVIIPFTPDVPCDNNGQRMWWAFL---ASSMVTFFGGLFIILLWRTLKYL 84

  Fly   142 RVILDKNPTFITCYGCEVGNKTEFIISAKLTEE---------EFQENP---------IINWDAIL 188
                     :..|..|.:.||....::..:|.:         |.:|.|         :.:|..::
Zfish    85 ---------WTVCCHCNIKNKEAQKVNNPITIQADGTTKTGNEKEEAPASEVGWMTSVKDWAGVM 140

  Fly   189 WVNRPT----VLWVLQLLLAMVSLTQSLV----------------------------LTYLGYK- 220
             ::..|    ||.||...|::.:|....:                            |.|.|.:
Zfish   141 -ISAQTLTGRVLVVLVFALSIGALGIYFIDSSDPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRF 204

  Fly   221 ----GNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLN-CWLAKRSLENMFNDLHRAM 280
                ..:|       |.||:.:.:.| .|:  ||   :|:.::|| .||..|.|        ||:
Zfish   205 IAANDKLW-------FWLEVNSVVDF-FTV--PP---VFVSVYLNRSWLGLRFL--------RAL 248

  Fly   281 QKSQ-SALSQQLTILSAT------LLCLVFTS----VCGIQH-----------FQRAGHRHLNLF 323
            :..| |.:.|.|.||..:      .||.:|.|    ..|..|           ||.:  :.|:.:
Zfish   249 RLIQFSEILQFLNILKTSNSIKLVNLCSIFISTWLTAAGFIHLVENSGDPWENFQNS--QPLSYW 311

  Fly   324 QSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHR 388
            :..|.::||.|||||||........:|:||..|...|.:..:...::......|:|.|||||:
Zfish   312 ECVYLLMVTMSTVGYGDVYARTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSA-- 374

  Fly   389 AQSEKHVVVCS-TTLHADTIMDFLNEFYAHPLLQDFYVVL-----LSP-MELDTTM-RMILQVPI 445
            ....||:|||. .||  :::.:||.:| .|....|..|.:     :|| :||:... |...||.
Zfish   375 VNGRKHIVVCGHITL--ESVSNFLKDF-LHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVE- 435

  Fly   446 WAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYV 510
                  :.|||.|...||||.::..|:||.|||.:..||..|.|...|:|..::|::.|.:....
Zfish   436 ------FYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIIT 494

  Fly   511 QIFRPEHKLHV--------KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSP 567
            |:.:..:|.|:        |..:..:|..|.|...:|.:|...|.||::..|.  |.....:...
Zfish   495 QMLQYHNKAHLLNIPSWNWKEGDDAICLAELKAGFIAQSCLAQGLSTMLANLF--SMRSYIKIEE 557

  Fly   568 EEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHS-----HRKYGVALVGVRPAELPEF 627
            :.|.:.|.:...||:|          .||...:|...||.:     :.|..:.|:.:      |:
Zfish   558 DTWQKYYLEGVANEMY----------TEYLSSAFVGLSFPTVCELCYVKLKLLLIAI------EY 606

  Fly   628 YEE--------TILLNPGPRHIMKKDDTC--YYMSITKEENSAFV---VNQNQTSDPTAAAKEGS 679
            ..|        .||:||| .|:..::.|.  :..|..||...||.   ...:..:||....|.|
Zfish   607 KSEQRESRSRKRILINPG-NHVKMQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCG- 669

  Fly   680 GTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAA 744
                                                      ...|.:
Zfish   670 ------------------------------------------CKRTKM----------------- 675

  Fly   745 APPPVPSVCVRVPHSPSYDSGGG------TTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFV 803
                  ||..|:..:..:|.|..      .:|:.|.......:::|
Zfish   676 ------SVYKRMKLACCFDCGRSERDCSCMSGSVHSNMDSLQRAFP------------------- 715

  Fly   804 PSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHS 868
                                                                     |...|.|.
Zfish   716 ---------------------------------------------------------LSSVSVHD 723

  Fly   869 MGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDD 933
            ..|||..:..........|:   ..:|:.|||. ..||.|..|.|....|.|.......|.||:.
Zfish   724 CSTSLRASKYKFNGYVRSLE---DEHPSTLSPK-KKQRNGGMRNSPNCSPKMMRHDPLLIPGNEQ 784

  Fly   934 GEEGDESDDEIDDE--MPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDS------YQRGCSFCSA 990
            .|..|.:....|..  ..| .||::|.            .:|::.||.|      :...|.|...
Zfish   785 IESMDANVKRYDSTGMFHW-CPSKEIE------------KVILTRSEASMTVLSGHVVVCIFGDV 836

  Fly   991 TASASAAAVAVAVAAAPAPAPAPAY----PSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYS 1051
            |    :|.|.:.....|..|....|    |....|            |.:||    ||..:..:
Zfish   837 T----SALVGLRNLVMPLRASNFHYHELKPIVFVG------------SLDYL----RREWETLH- 880

  Fly  1052 CDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGS 1116
                  :.|.:.:       |.|..|:|...|...:..|..|...:|....
Zfish   881 ------NFPKVFI-------LPGTPLSRADLRAVNINLCDMCVILSANQNN-------------- 918

  Fly  1117 GATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCE 1181
                 ...:|::           |..||:...
Zfish   919 -----IDDASLQ-----------DKECILASL--------------------------------- 934

  Fly  1182 HCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALS 1246
                 |.|..|:.:...:|.|:  |.|   |..|  ...||....:|:..|:.:    |.:...|
Zfish   935 -----NIKSMQFDDSIGVLQAN--SQG---FTPP--GMDRSSPDNSPVHGLVRQ----ASVTTGS 983

  Fly  1247 YFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIK 1311
            ..|::          .:|.:.|..|        ..:|.|.|::|.:                :|:
Zfish   984 NIPII----------TELAKPGKLL--------PLVSFSQEKNSGT----------------NIQ 1014

  Fly  1312 SITELSQSSNMRFMQFRAHD--KYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLL 1374
            .||||...||::|:.....|  ...|:|::                  |||.|..|:.|:||:|:
Zfish  1015 MITELVNDSNVQFLDQDDDDDPDTELYLTQ------------------PFACGTAFAVSVLDSLM 1061

  Fly  1375 YQAFVKDYVITFVR------------LLLGIDQAPGSGFLTSMRITKDDMWIRT----------- 1416
            ...:..|.::|.:|            .||..:.|...|:.|...:...|. .|.
Zfish  1062 SATYFNDNILTLIRTLVTGGATPELEALLAEENALRGGYSTPQTLANRDR-CRVAQLALYDGPFA 1125

  Fly  1417 -------YGRLYQKLCSTTCEIPIGIYRTQDTSNADTSH------VSNSPVERWGPFSAFSRHCV 1468
                   ||.|:.|...|...:..||||.:|......|.      ::|.|.|    |.......:
Zfish  1126 DLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLGAPSQCTKRYVITNPPYE----FEMVPTDLI 1186

  Fly  1469 RLRPSYDEETG--------TPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRS--VNCLG 1523
            .....:|...|        :..|:..|::....|...|..:....:|..|....:|.:  :|.:|
Zfish  1187 FCLMQFDHNAGQSRASLSHSSHSSHSSSKKSSSVHSIPATNRQNRSSKAREARDKQNATRMNRMG 1251

  Fly  1524 GCSERKGSSYSINLADEARDNHAQQIE----RAEIANLVRSRMESLNL--PTIDYDD 1574
              .|::.      ..|||.:.:.:.|:    ...:||.|.....:.:|  |..:.:|
Zfish  1252 --PEKRW------FTDEAENAYPRNIQIKPMSTHMANQVNQYKSTSSLIPPIREVED 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	16/43 (37%)
		BK_channel_a	525..619	CDD:460947	22/98 (22%)
kcnma1a	XP_009305518.1	Ion_trans	150..367	CDD:459842	57/239 (24%)
		PRK10537	<314..474	CDD:236711	59/171 (35%)
		BK_channel_a	517..604	CDD:460947	22/98 (22%)