Protein Alignment SLO2 and kcnt2

DIOPT Version :9

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_021324135.1
• Gene: kcnt2 / 568327
• ZFINID: ZDB-GENE-130530-783
• Length: 1130
• Species: Danio rerio
• Alignment Length: 1555
• Identity: 546/1555 - (35%)
• Similarity: 770/1555 - (49%)
• Gaps: 487/1555 - (31%)

  Fly    92 DERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILD-KNPTFITCY 155
            |.:.:||:.|.|::||||||.|.||||||||.:|:..|.||:|||:||:.||:.| |:.|..:.:
Zfish    25 DPKFQVEFLVKESSFKERLQWYLIKNQRSSLSVRVFYLSLKVLSCILYVSRVLTDCKHQTQCSSH 89

  Fly   156 GCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYK 220
            .   ||.|       |.|        |:|..::||:|..:||.:|:.:|::.|...::||||.|:
Zfish    90 H---GNYT-------LLE--------IDWAPVIWVDRNEILWAVQVSVAVICLFMRILLTYLRYR 136

  Fly   221 GNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQS 285
            |||.||:|...|||||:.|:||.:.|.:...|.||:|:|||||||||:||:..||||||:.::||
Zfish   137 GNILQQVLQMAFILELIDTVPFVIGIFYQSFRKLFVPVFLNCWLAKRALESTVNDLHRAIHRTQS 201

  Fly   286 ALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQL 350
            |:..|:.:|.:|::||:||.:||::|.||||.: |.:|.|.|:.:|||||||:||.|||||||:|
Zfish   202 AMFNQVLMLISTIVCLIFTFICGVEHLQRAGTK-LTVFDSFYFCIVTFSTVGFGDVVPDIWPSKL 265

  Fly   351 YMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFY 415
            .:|.||.|.|:|||.|||:||:.||||||.||.||..||::|||||:|.:::..|.:||||||||
Zfish   266 LVVFMILVTLMVLPIQFEELAYLWMERQKSGGYYSRQRAETEKHVVLCVSSIKIDLLMDFLNEFY 330

  Fly   416 AHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAAR 480
            |||.|::.||::|.|.|||..:|.:|::|:|:.||||:|||.|||.||.||:::.|||||||..|
Zfish   331 AHPKLEEHYVIILCPTELDAAVRSVLRIPMWSHRVIYLQGSALKDQDLVRAKLDYAEACFILTCR 395

  Fly   481 NYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCP 545
            ..||:.|||..||||:||||||||....:|||.:||:|.|||||:|:|||:|||:|:||.||.||
Zfish   396 CVADRNAADYQTILRAWAVKDFAPGCTLFVQILKPENKFHVKFADHIVCEEEFKFAMLAMNCICP 460

  Fly   546 GASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHR 610
            ..||.:|||:|||:|.|||.|||:|||:||||||||:|.|||..|.||.||||.:|.||||:::.
Zfish   461 ATSTFITLLVHTSQGLEGQHSPEDWHRIYGKCSGNEVYSIVLNKSIFFSEYEGNNFAYASFNAYN 525

  Fly   611 KYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAA 675
            |||:.|:||.|.:     .::||||||.::.|...|||:|:|:||||||  .|.|.:..:
Zfish   526 KYGICLIGVCPED-----TKSILLNPGAQYTMNAMDTCFYISLTKEENS--YVKQRECGN----- 578

  Fly   676 KEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATS 740
                                                                             
Zfish   579 ----------------------------------------------------------------- 578

  Fly   741 TAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPS 805
                                                                             
Zfish   579 ----------------------------------------------------------------- 578

  Fly   806 ENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMG 870
                                       .:.|.||                             ||
Zfish   579 ---------------------------NSKTQPP-----------------------------MG 587

  Fly   871 TSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGE 935
            :::: .|.|:......:.:|.:..|:|.:....::|   |:|.|:||.::..|.||..:....|:
Zfish   588 SAIT-RPGTMAIDIQEISIPSSLEPSLSTGANTSER---RQPIIIPVLELPDSPSFQASKLLSGQ 648

  Fly   936 -----EGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASAS 995
                 .||||:|                   |:|
Zfish   649 SKSHINGDESND-------------------GYF------------------------------- 663

  Fly   996 AAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVP 1060
                                                                             
Zfish   664 ----------------------------------------------------------------- 663

  Fly  1061 GMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSS 1125
                                                                             
Zfish   664 ----------------------------------------------------------------- 663

  Fly  1126 SVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQ----LAQVCEHCSYR 1186
                                .|:||..|:||.|..||:|.|:|.|.||:.    |::.|.|....
Zfish   664 --------------------IGYPPNLPYIGSSTILCHLRKKKMPTCCMHLEKFLSKTCNHKDDE 708

  Fly  1187 NAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLV 1251
            :||.|..::|.:|::.:.|.|.:||||:||||.:|.:..|.||:||||..||..||:.:|:||::
Zfish   709 DAKVYSLKSKLVIVSVETAGNSLYNFILPLRASYRPQNELWPIVLLLEHVPDEEFLETISWFPMI 773

  Fly  1252 YWMLGSID----------C---------LDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTI 1297
            |::|||||          |         ||||||.|::.|.|:|||:||.:.:|:||.::|..||
Zfish   774 YYLLGSIDSTITVVLNYACNIFSAFPYSLDDLLRCGVSFAASMVVVDKESTMTAKEDYMADAKTI 838

  Fly  1298 VAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAG 1362
            |.||.:|:.|..:..||||:.|:|||||||...|.::|..||:.|:|:|:||::|::|.||||||
Zfish   839 VNVQTLFRLFSGLNIITELTHSANMRFMQFSTKDCHSLAFSKLAKKEREKGSNLSFIFHLPFAAG 903

  Fly  1363 AVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCST 1427
            .|||.|||||||||:|||||:||..|||||::..|.||||.:|.||::|:.|.|||||||:|.||
Zfish   904 RVFSISMLDTLLYQSFVKDYMITITRLLLGLETTPQSGFLCAMSITEEDLCIETYGRLYQRLSST 968

  Fly  1428 TCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLRPSY--DEETGTPDSTKDSTEM 1490
            ..:||||||||:       |....||.                .|.:  .::....|...|..|.
Zfish   969 VGDIPIGIYRTK-------SQTVESPE----------------TPQFQMSDKASVFDEGGDLDEQ 1010

  Fly  1491 LRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQI---ERA 1552
            .:.:....|.      |..:.|..|:||:.   ..|...|..::...||....:....:   ||.
Zfish  1011 HQNLQCEIPD------SQLQTQSLRRRSMQ---WASSLLGPWHTEREADRLSQHRGVLLSCSERL 1066

  Fly  1553 EIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQ 1612
            |:..||:.||::|.|.|:.:|:.:..:|..:|::||||.|.|||..|::|::|....|::
Zfish  1067 EVTELVKKRMKNLGLSTLGFDEQTNIKNSHAYILINPSSDTKLELNDIVYIIRKDTLSSK 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	38/65 (58%)
		BK_channel_a	524..619	CDD:281490	61/94 (65%)
kcnt2	XP_021324135.1	Ion_trans	<148..278	CDD:306908	73/130 (56%)
		Ion_trans_2	<234..286	CDD:311712	32/52 (62%)
		BK_channel_a	439..534	CDD:308870	61/94 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750