Protein Alignment SLO2 and kcnt2a

DIOPT Version :10

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_068069686.1
• Gene: kcnt2a / 568327
• ZFINID: ZDB-GENE-130530-783
• Length: 1111
• Species: Danio rerio
• Alignment Length: 1536
• Identity: 545/1536 - (35%)
• Similarity: 769/1536 - (50%)
• Gaps: 468/1536 - (30%)

  Fly    92 DERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILD-KNPTFITCY 155
            |.:.:||:.|.|::||||||.|.||||||||.:|:..|.||:|||:||:.||:.| |:.|..:.:
Zfish    25 DPKFQVEFLVKESSFKERLQWYLIKNQRSSLSVRVFYLSLKVLSCILYVSRVLTDCKHQTQCSSH 89

  Fly   156 GCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYK 220
            .   ||.|       |.|        |:|..::||:|..:||.:|:.:|::.|...::||||.|:
Zfish    90 H---GNYT-------LLE--------IDWAPVIWVDRNEILWAVQVSVAVICLFMRILLTYLRYR 136

  Fly   221 GNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQS 285
            |||.||:|...|||||:.|:||.:.|.:...|.||:|:|||||||||:||:..||||||:.::||
Zfish   137 GNILQQVLQMAFILELIDTVPFVIGIFYQSFRKLFVPVFLNCWLAKRALESTVNDLHRAIHRTQS 201

  Fly   286 ALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQL 350
            |:..|:.:|.:|::||:||.:||::|.||||.: |.:|.|.|:.:|||||||:||.|||||||:|
Zfish   202 AMFNQVLMLISTIVCLIFTFICGVEHLQRAGTK-LTVFDSFYFCIVTFSTVGFGDVVPDIWPSKL 265

  Fly   351 YMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFY 415
            .:|.||.|.|:|||.|||:||:.||||||.||.||..||::|||||:|.:::..|.:||||||||
Zfish   266 LVVFMILVTLMVLPIQFEELAYLWMERQKSGGYYSRQRAETEKHVVLCVSSIKIDLLMDFLNEFY 330

  Fly   416 AHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAAR 480
            |||.|::.||::|.|.|||..:|.:|::|:|:.||||:|||.|||.||.||:::.|||||||..|
Zfish   331 AHPKLEEHYVIILCPTELDAAVRSVLRIPMWSHRVIYLQGSALKDQDLVRAKLDYAEACFILTCR 395

  Fly   481 NYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCP 545
            ..||:.|||..||||:||||||||....:|||.:||:|.|||||:|:|||:|||:|:||.||.||
Zfish   396 CVADRNAADYQTILRAWAVKDFAPGCTLFVQILKPENKFHVKFADHIVCEEEFKFAMLAMNCICP 460

  Fly   546 GASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHR 610
            ..||.:|||:|||:|.|||.|||:|||:||||||||:|.|||..|.||.||||.:|.||||:::.
Zfish   461 ATSTFITLLVHTSQGLEGQHSPEDWHRIYGKCSGNEVYSIVLNKSIFFSEYEGNNFAYASFNAYN 525

  Fly   611 KYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAA 675
            |||:.|:||.|.:     .::||||||.::.|...|||:|:|:||||||  .|.|.:..:
Zfish   526 KYGICLIGVCPED-----TKSILLNPGAQYTMNAMDTCFYISLTKEENS--YVKQRECGN----- 578

  Fly   676 KEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATS 740
                                                                             
Zfish   579 ----------------------------------------------------------------- 578

  Fly   741 TAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPS 805
                                                                             
Zfish   579 ----------------------------------------------------------------- 578

  Fly   806 ENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMG 870
                                       .:.|.||                             ||
Zfish   579 ---------------------------NSKTQPP-----------------------------MG 587

  Fly   871 TSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGE 935
            :::: .|.|:......:.:|.:..|:|.:....::|   |:|.|:||.::..|.||..:....|:
Zfish   588 SAIT-RPGTMAIDIQEISIPSSLEPSLSTGANTSER---RQPIIIPVLELPDSPSFQASKLLSGQ 648

  Fly   936 -----EGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASAS 995
                 .||||:|                   |:|
Zfish   649 SKSHINGDESND-------------------GYF------------------------------- 663

  Fly   996 AAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVP 1060
                                                                             
Zfish   664 ----------------------------------------------------------------- 663

  Fly  1061 GMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSS 1125
                                                                             
Zfish   664 ----------------------------------------------------------------- 663

  Fly  1126 SVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQ----LAQVCEHCSYR 1186
                                .|:||..|:||.|..||:|.|:|.|.||:.    |::.|.|....
Zfish   664 --------------------IGYPPNLPYIGSSTILCHLRKKKMPTCCMHLEKFLSKTCNHKDDE 708

  Fly  1187 NAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLV 1251
            :||.|..::|.:|::.:.|.|.:||||:||||.:|.:..|.||:||||..||..||:.:|:||::
Zfish   709 DAKVYSLKSKLVIVSVETAGNSLYNFILPLRASYRPQNELWPIVLLLEHVPDEEFLETISWFPMI 773

  Fly  1252 YWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITEL 1316
            |::|||||.||||||.|::.|.|:|||:||.:.:|:||.::|..|||.||.:|:.|..:..||||
Zfish   774 YYLLGSIDSLDDLLRCGVSFAASMVVVDKESTMTAKEDYMADAKTIVNVQTLFRLFSGLNIITEL 838

  Fly  1317 SQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKD 1381
            :.|:|||||||...|.::|..||:.|:|:|:||::|::|.||||||.|||.|||||||||:||||
Zfish   839 THSANMRFMQFSTKDCHSLAFSKLAKKEREKGSNLSFIFHLPFAAGRVFSISMLDTLLYQSFVKD 903

  Fly  1382 YVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADT 1446
            |:||..|||||::..|.||||.:|.||::|:.|.|||||||:|.||..:||||||||:
Zfish   904 YMITITRLLLGLETTPQSGFLCAMSITEEDLCIETYGRLYQRLSSTVGDIPIGIYRTK------- 961

  Fly  1447 SHVSNSPVERWGPFSAFSRHCVRLRPSY--DEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSF 1509
            |....||.                .|.:  .::....|...|..|..:.:....|.      |..
Zfish   962 SQTVESPE----------------TPQFQMSDKASVFDEGGDLDEQHQNLQCEIPD------SQL 1004

  Fly  1510 RPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQI---ERAEIANLVRSRMESLNLPTID 1571
            :.|..|:||:.   ..|...|..::...||....:....:   ||.|:..||:.||::|.|.|:.
Zfish  1005 QTQSLRRRSMQ---WASSLLGPWHTEREADRLSQHRGVLLSCSERLEVTELVKKRMKNLGLSTLG 1066

  Fly  1572 YDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQ 1612
            :|:.:..:|..:|::||||.|.|||..|::|::|....|::
Zfish  1067 FDEQTNIKNSHAYILINPSSDTKLELNDIVYIIRKDTLSSK 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	26/43 (60%)
		BK_channel_a	525..619	CDD:460947	60/93 (65%)
kcnt2a	XP_068069686.1	Ion_trans	<148..278	CDD:459842	73/130 (56%)
		Ion_trans_2	214..286	CDD:462301	43/72 (60%)
		BK_channel_a	440..534	CDD:460947	60/93 (65%)