Protein Alignment SLO2 and LOC565691

DIOPT Version :9

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_009298041.1
• Gene: LOC565691 / 565691
• -ID: -
• Length: 1231
• Species: Danio rerio
• Alignment Length: 1615
• Identity: 634/1615 - (39%)
• Similarity: 849/1615 - (52%)
• Gaps: 457/1615 - (28%)

  Fly    58 LPTAPAVRRFSKSIFQRPRSMSVWSDISRSSMRLDERVRVEYYVNENTFKERLQLYFIKNQRSSL 122
            ||..|..|               :.|:.....:.|:||:||:|||||||||||:|:|||||||||
Zfish     9 LPLPPRYR---------------FRDLLLGDWQTDDRVQVEFYVNENTFKERLKLFFIKNQRSSL 58

  Fly   123 RIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGC-----EVGNKTEFIISAKLTEEEFQENPII 182
            |:|:.:.|||:|||:|||:||:||.......|.||     ...|::.|
Zfish    59 RVRLFNFFLKVLSCLLYIVRVLLDDPREERDCPGCLRQNASAHNRSHF----------------- 106

  Fly   183 NWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIV 247
            :|..|:|||||..||.||:|:|.:|.:::::|.||.||||:|:|:|...||||:::.:||.:|::
Zfish   107 DWSLIIWVNRPLPLWALQVLVAFISFSETMLLVYLSYKGNVWEQVLRIPFILEMISAVPFVITVI 171

  Fly   248 HPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHF 312
            .|.|||||||:||||||||.:||||.||||||:|::.||:..|:.||.:|||||:||.:|||||.
Zfish   172 LPSLRNLFIPVFLNCWLAKHALENMINDLHRAIQRTHSAMFNQVLILISTLLCLIFTCICGIQHL 236

  Fly   313 QRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMER 377
            :|||: :|.||.|.|:.||||||||:||..|.||||||.:||||||||||||.|||||||.||||
Zfish   237 ERAGN-NLTLFDSLYFCVVTFSTVGFGDVTPQIWPSQLLVVIMICVALIVLPIQFEQLAFLWMER 300

  Fly   378 QKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQ 442
            ||.||:||.:|||:|||||:|.:.|..|.:|||||||:|||.|||:|||:|.|.|:|..:|.:|.
Zfish   301 QKSGGNYSRYRAQTEKHVVLCVSCLKIDLLMDFLNEFFAHPRLQDYYVVILCPAEMDVQVRRVLH 365

  Fly   443 VPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVP 507
            :|:|||||||:|||.|||.||.||:|::|||||||:.|...|:.|||..||||:|||||||||.|
Zfish   366 IPLWAQRVIYLQGSALKDQDLMRAKMDDAEACFILSNRFEVDRFAADHQTILRAWAVKDFAPNCP 430

  Fly   508 QYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQE---------- 562
            .||||.:||:|.|:|||:|||||:|||||:||.||.||..|||:|||:|:||||.
Zfish   431 LYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCVCPATSTLITLLIHSSRGQTASSEAFRQRA 495

  Fly   563 ----------GQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALV 617
                      |..|.::|.|.|.:|:.||::||.|.:|:|||||:|||||:||||:|:||||.|:
Zfish   496 GAFQPLNREGGASSVDQWQRTYRRCAANEVHHIRLEESKFFGEYQGKSFTFASFHAHKKYGVCLI 560

  Fly   618 GVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTG 682
            |||..:     ...|||||||.|||...|||:|::|:||||||||....:.            ..
Zfish   561 GVRRMD-----TANILLNPGPCHIMGASDTCFYINISKEENSAFVRGHREP------------VR 608

  Fly   683 GGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPP 747
            |.||.|....                         .|.:...|.|
Zfish   609 GPGGDSRGVP-------------------------QTIYHGLTRL-------------------- 628

  Fly   748 PVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVI 812
            ||.|:                                                  :.|....|:.
Zfish   629 PVHSI--------------------------------------------------IASMGTVAID 643

  Fly   813 ISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMG--TSLSI 875
            :.||..:                          ||.      |.|...||.|:....|  |.:|:
Zfish   644 LQDSSDS--------------------------SPE------GSGPAALGSGTVSRSGCRTEVSV 676

  Fly   876 TPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDES 940
            .        |.|.:|..:...       .:||.|..| :|.|.|...:|:|.:.       ||:|
Zfish   677 C--------NTLSLPAVSGSG-------EERRHSIAP-VLEVVDGVHNSTFDLL-------GDQS 718

  Fly   941 DDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAA 1005
            :||
Zfish   719 EDE-------------------------------------------------------------- 721

  Fly  1006 APAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGV 1070
                          .||.|...|.                               |...|...|
Zfish   722 --------------GGEEGKEEDG-------------------------------GEQKGQWWG- 740

  Fly  1071 GLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRP 1135
                                :.|.
Zfish   741 --------------------AHCE----------------------------------------- 744

  Fly  1136 VWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIIL 1200
             |       |||:|..||:||.||.||:||:||.|.|||:|.:.|.|..|.:|:.|.::||.||:
Zfish   745 -W-------VKGYPLNSPYIGSSPALCHLLQEKMPFCCLRLDKACHHMPYEDARSYGFKNKLIIV 801

  Fly  1201 AADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLL 1265
            :|:.|.||:||||:||||::|.:..||||:||||..|:..||:|:.:||:|::.:||||.||.||
Zfish   802 SAESAGNGLYNFIVPLRAYYRPRKELNPIVLLLENVPEADFLEAICWFPMVFYTVGSIDNLDSLL 866

  Fly  1266 RAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAH 1330
            |.|:|.|:::|||:||.|..||||.::|..|||.||.:|:.||::..||||:..:|||||||:..
Zfish   867 RCGVTFADTMVVVDKESSMIAEEDYMADAKTIVNVQTLFRLFPALSIITELTHPANMRFMQFKVK 931

  Fly  1331 DKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQ 1395
            |.|:|.|||:||:|:||||::.:|||||||||.|||.|||||||||:|||||:|:..|||||:|.
Zfish   932 DHYSLALSKLEKKERERGSNLVFMFRLPFAAGKVFSVSMLDTLLYQSFVKDYMISITRLLLGLDS 996

  Fly  1396 APGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPF 1460
            .||||||.:|:||::|:||||||||||||||:|.:||||||||:       :|
Zfish   997 MPGSGFLCAMKITEEDLWIRTYGRLYQKLCSSTGDIPIGIYRTE-------AH------------ 1042

  Fly  1461 SAFSRHCVRLRPSYDEETGTPDSTKDSTE-----MLRGVTYR------PPGSATGGASSFRP--- 1511
                    :|..|..:.:.|.:..:|:.|     :.|...:|      ||.|::...:...|
Zfish  1043 --------KLPVSESQVSITVEDYEDTREPREPLLCRSGLHRNSTSSEPPSSSSSSQAMDHPLLR 1099

  Fly  1512 ----QPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDY 1572
                |..|:.|.....|....||...:.....:.|.:..::.||.|:..|||:||:.|.|....:
Zfish  1100 RKSMQWARRLSRKSGRGSGGAKGVGSAAERITQQRLSLFRRSERQELNALVRTRMKHLGLSPSGF 1164

  Fly  1573 DDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRP---SPFSAQKTFERHNSRRKS 1624
            :.::::.|.|||::||||.|.:||..|::||:||   ||...|.     .||:.|
Zfish  1165 NGMTDQGNRLSYILINPSPDTRLELHDVVYLIRPDLLSPVPNQA-----GSRKPS 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	46/65 (71%)
		BK_channel_a	524..619	CDD:281490	60/114 (53%)
LOC565691	XP_009298041.1	Ion_trans	<156..286	CDD:278921	85/130 (65%)
		Ion_trans_2	<241..288	CDD:285168	33/47 (70%)
		BK_channel_a	447..562	CDD:281490	60/114 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587080
Domainoid	1	1.000	482	1.000	Domainoid score	I394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I222
OMA	1	1.010	-	-		QHG48024
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	1	1.000	-	-		FOG0002662
OrthoInspector	1	1.000	-	-		otm24770
orthoMCL	1	0.900	-	-		OOG6_103731
Panther	1	1.100	-	-	LDO	PTHR10027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910