DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and kcnt1b

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	XP_021332348.1	Gene:	kcnt1b / 563670	ZFINID:	ZDB-GENE-141210-6	Length:	1261	Species:	Danio rerio

Alignment Length:	1659	Identity:	661/1659 - (39%)
Similarity:	874/1659 - (52%)	Gaps:	504/1659 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SYSMPSVASPSLN---------HRLQRNVNFNE----DLNDL-AGYPPQQLPTAPAVRRFSKSIF 72
            |.:.||:..|..:         ..:|||.:.|.    |::.| ......::|..|...||...:
Zfish     8 SQAEPSMTPPRRSSTAADRLPTETVQRNNSSNTGVILDISTLKLADVDSEVPPLPPRYRFRDLL- 71

  Fly    73 QRPRSMSVWSDISRSSMRLDERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCV 137
                       :...|.:.|:||:||:|||||||||||:|:||||||||||||:.:|.||||:|:
Zfish    72 -----------LGDQSFQNDDRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNLSLKLLTCL 125

  Fly   138 LYIIRVILDKNPTFITCYGCEVGNKTEFIIS-------AKLTEEEFQENPIINWDAILWVNRPTV 195
            ||||||.||.....:||......|.|:.:.|       |.||.:..|    |||:.|.||||...
Zfish   126 LYIIRVSLDDPTNQVTCARKHCANITDALCSKACANYTANLTADPTQ----INWELIFWVNRRVP 186

  Fly   196 LWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFL 260
            :|.:|:.:|::|..|:::|.||.||||||:||....||:|::.|:||.:||..|||||:|:|:||
Zfish   187 VWAIQVTVALISFLQAMLLVYLSYKGNIWEQIFQISFIIEMINTVPFIITIFWPPLRNIFVPVFL 251

  Fly   261 NCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQS 325
            ||||||.:||||.||||||:|::.||:..|:.||..||||||||..|||||.:||| ::|.||.:
Zfish   252 NCWLAKSALENMINDLHRAIQRTHSAMFNQVLILICTLLCLVFTGACGIQHLERAG-KNLTLFDA 315

  Fly   326 TYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQ 390
            .|:.:||||||||||..|.||||||.:||||||||:|||.|||:||:.||||||.||:||.||||
Zfish   316 LYFCIVTFSTVGYGDVTPRIWPSQLLVVIMICVALVVLPLQFEELAYLWMERQKSGGNYSRHRAQ 380

  Fly   391 SEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQG 455
            :|||||:|.|:|..|.:|||||||||||.|||:|||:|.|.|:|..:|.|||:|:|:|||||:||
Zfish   381 TEKHVVLCVTSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDIQVRRILQIPLWSQRVIYLQG 445

  Fly   456 SCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLH 520
            |.|||.||.||:|::|||||||::||..|:||||..||||:|||||||||.|.||||.:||:|.|
Zfish   446 SALKDQDLMRAKMDDAEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFH 510

  Fly   521 VKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHI 585
            ||||:|||||:|||||:||.||.||..|||||||:|||||||||.|||:|.|.||:|||||:|||
Zfish   511 VKFADHVVCEEEFKYAMLALNCVCPATSTLVTLLVHTSRGQEGQTSPEQWQRTYGRCSGNEVYHI 575

  Fly   586 VLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYY 650
            .|.||:|||||:||||||||||:|:||||.|:|.:..:     .::|||||||||||...|||||
Zfish   576 RLMDSKFFGEYDGKSFTYASFHAHKKYGVCLIGTKRED-----NKSILLNPGPRHIMSATDTCYY 635

  Fly   651 MSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTT 715
            ::|||||||||:..|.:        |...|.        ||:..:.|.:..|..:|..::
Zfish   636 INITKEENSAFIFKQEE--------KHSKGL--------SAAGVYDAPSRLPVQSIIASM----- 679

  Fly   716 TISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYP 780
                                                    |..|.||       ||..:.
Zfish   680 ----------------------------------------VDQSTSY-------GTVAID----- 692

  Fly   781 QSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMG 845
                     :|.||                                            ||..:
Zfish   693 ---------LQNPD--------------------------------------------PPADS-- 702

  Fly   846 SPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSR 910
                                                   |.|.:|..|.            .|||
Zfish   703 ---------------------------------------NKLALPTENG------------AGSR 716

  Fly   911 RPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMS 975
            ||||.||.::..||:.                              :.|           .|:..
Zfish   717 RPSIAPVLEIADSSAI------------------------------LPC-----------DLLND 740

  Fly   976 SSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQ 1040
            .|||.                                    ::.:.|.|
Zfish   741 PSEDE------------------------------------TNQSDEDG---------------- 753

  Fly  1041 LRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPA 1105
                                                                          .||
Zfish   754 --------------------------------------------------------------APA 756

  Fly  1106 VAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKP 1170
            :                                   .| |||:||.||:||.|||||:||::|.|
Zfish   757 I-----------------------------------DC-VKGYPPNSPYIGSSPTLCHLLQQKAP 785

  Fly  1171 LCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLER 1235
            .|||:|.:.|.|.|:.:||.|.::||.||::|:.|.||:||||:||||::|.:..||||:|||:.
Zfish   786 FCCLRLDKGCRHNSFEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRPRKELNPIVLLLDN 850

  Fly  1236 RPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAV 1300
            .||..||:|:..||:||:|.|:||.||:||:.||..|:::|||:||.:.|||||.::|..|||.|
Zfish   851 PPDNHFLEAICCFPMVYYMAGTIDNLDNLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNV 915

  Fly  1301 QNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVF 1365
            |.||:.|||:..||||:..||||||||||.|.|:|.|||:||.|:::||::::|||||||||.||
Zfish   916 QTMFRLFPSLSIITELTHPSNMRFMQFRAKDCYSLALSKLEKIERDKGSNLAFMFRLPFAAGRVF 980

  Fly  1366 SASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCE 1430
            |.|||||||||:|||||:|...|||||:|..||||:|.:|::|::|:||||||||:|||||::.|
Zfish   981 SISMLDTLLYQSFVKDYMILIARLLLGLDTTPGSGYLCAMKVTEEDLWIRTYGRLFQKLCSSSAE 1045

  Fly  1431 IPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRL---RPSYDEETGTPDST-------- 1484
            ||||||||:  |:..:|..|...||          .|...   |.|:.|:|...:||
Zfish  1046 IPIGIYRTE--SHMFSSSESQVSVE----------DCEDQRDHRESWKEKTAHRNSTGSDQSEHP 1098

  Fly  1485 ---KDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHA 1546
               |.|.:..|.::.:          :.:| |.|...:|                   :.|.|..
Zfish  1099 LLRKKSMQWARRLSRK----------NTKP-PSRAERIN-------------------QQRLNLY 1133

  Fly  1547 QQIERAEIANLVRSRMESLNLPTIDYDDV-----------------------------------S 1576
            ::.||.|::.||::||:.|.|||:.|:||                                   :
Zfish  1134 RRSERQELSELVKNRMKHLGLPTVGYEDVANLTASDVMNRVNLGYLQEGTYMTEGTAVAQTDEMN 1198

  Fly  1577 EKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFS 1610
            :.:|.||||:|||..|..||..|::|::|..|.:
Zfish  1199 DNQNTLSYVLINPPPDTILELNDIVYIIRSDPLA 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	45/65 (69%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	72/94 (77%)
kcnt1b	XP_021332348.1	Ion_trans_2	<309..361	CDD:311712	35/51 (69%)
kcnt1b	XP_021332348.1	BK_channel_a	514..608	CDD:308870	72/93 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587081
Domainoid	1	1.000	482	1.000	Domainoid score	I394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I222
OMA	1	1.010	-	-		QHG48024
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	1	1.000	-	-		FOG0002662
OrthoInspector	1	1.000	-	-		otm24770
orthoMCL	1	0.900	-	-		OOG6_103731
Panther	1	1.100	-	-	O	PTHR10027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910