DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and Kcnt2

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	XP_017454291.1	Gene:	Kcnt2 / 304827	RGDID:	735074	Length:	1167	Species:	Rattus norvegicus

Alignment Length:	1574	Identity:	646/1574 - (41%)
Similarity:	842/1574 - (53%)	Gaps:	496/1574 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYG 156
            |:||:||:|:|||||||||:|:||||||||||||:.:..||||||:||||||:|:| |:
  Rat    30 DDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLEK-PS------ 87

  Fly   157 CEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKG 221
              .||                     :|..|.||||...||.||:.:|::||.::::|.||.|||
  Rat    88 --QGN---------------------DWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKG 129

  Fly   222 NIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSA 286
            |||:|||...||||::..:||.::|..|.|||||:|:||||||||.:||||.||||||:|::|||
  Rat   130 NIWEQILRVPFILEIINAVPFIISIFWPTLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSA 194

  Fly   287 LSQQLTILSATLLCLVFT-------------------------SVCGIQHFQRAGHRHLNLFQST 326
            :..|:.||.:|||||:||                         |:|||||.:|.| :.||||.|.
  Rat   195 MFNQVLILISTLLCLIFTCFTDKTREHMYHVTLGFTETLTFSQSICGIQHLERIG-KKLNLFDSL 258

  Fly   327 YYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQS 391
            |:.:|||||||:||..|:.|.|:|::|.||||||:|||.||||||:.||||||.||:||.||||:
  Rat   259 YFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQT 323

  Fly   392 EKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGS 456
            |||||:|.::|..|.:|||||||||||.|||:|||:|.|.|:|..:|.:||:|:|:|||||:|||
  Rat   324 EKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGS 388

  Fly   457 CLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHV 521
            .|||.||.||:|:.|||||||::|...|:|::|..||||:|||||||||.|.||||.:||:|.|:
  Rat   389 ALKDQDLLRAKMDNAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHI 453

  Fly   522 KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIV 586
            |||:|||||:|||||:||.||.||..|||:|||:|||||||||||||:|.:.||:|||||:||||
  Rat   454 KFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKTYGRCSGNEVYHIV 518

  Fly   587 LGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYM 651
            |.:|.||.|||||||||||||:|:|:||.|||||..:     .:.||||||||:||...|.|:|:
  Rat   519 LEESTFFAEYEGKSFTYASFHAHKKFGVCLVGVRRED-----NKNILLNPGPRYIMNASDICFYI 578

  Fly   652 SITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTT 716
            :||||||||| .||:|...                ::.|.|.:|     .|
  Rat   579 NITKEENSAF-KNQDQQRK----------------SNVSRSFYH-----GP-------------- 607

  Fly   717 ISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQ 781
             |.....|.:.|..|....:..||..||:.|
  Rat   608 -SRLPVHSIIASMGTVAIDLQDTSCRAASGP---------------------------------- 637

  Fly   782 SYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGS 846
                              :|.:|||
  Rat   638 ------------------TLALPSE---------------------------------------- 644

  Fly   847 PSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRR 911
                        ||..|                                              ||
  Rat   645 ------------GGKEL----------------------------------------------RR 651

  Fly   912 PSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSS 976
            |||.||.::..:||.                                         :|..|:...
  Rat   652 PSIAPVLEVADTSSI-----------------------------------------QTCDLLSDQ 675

  Fly   977 SEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQL 1041
            |||.                                                  ..|.||
  Rat   676 SEDE--------------------------------------------------TTPDEE----- 685

  Fly  1042 RRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAV 1106

  Rat   686 ----------------------------------------------------------------- 685

  Fly  1107 AATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPL 1171
                            :||::|               ..||:||.||:||.|||.|:||:||.|.
  Rat   686 ----------------TSSNLE---------------YAKGYPPYSPYIGSSPTFCHLLQEKVPF 719

  Fly  1172 CCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERR 1236
            |||:|.:.|:|..|.:||.|.::||.||:||:.|.||:||||:||||::|.|..||||:|||:..
  Rat   720 CCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNP 784

  Fly  1237 PDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQ 1301
            ||:.||||:.:||:||:|:||||.||||||.|:|.|.::|||:||.:.|||||.::|..|||.||
  Rat   785 PDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQ 849

  Fly  1302 NMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFS 1366
            .:|:.|.|:..||||:..:|||||||||.|.|:|.|||:||:|:||||::::|||||||||.|||
  Rat   850 TLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFS 914

  Fly  1367 ASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEI 1431
            .|||||||||:|||||:|:..|||||:|..||||||.||:||:||:|||||.||||||||:|.::
  Rat   915 ISMLDTLLYQSFVKDYMISITRLLLGLDTIPGSGFLCSMKITEDDLWIRTYARLYQKLCSSTGDV 979

  Fly  1432 PIGIYRTQD----TSN----ADTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDST 1488
            |||||||:.    ||.    |..|.:|.| ||.|                        :.|||
  Rat   980 PIGIYRTESQKLTTSESREIASQSQISIS-VEEW------------------------EDTKD-- 1017

  Fly  1489 EMLRGVTYRPPG-------SATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLAD---EARD 1543
                   .:.||       ::|....|..|. .|::|:......| |||..:|...|:   :.|.
  Rat  1018 -------VKDPGHHRSIHRNSTSSDQSDHPL-LRRKSMQWARRLS-RKGPKHSGKTAEKITQQRL 1073

  Fly  1544 NHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSP 1608
            |..::.||.|:|.||::||:.|.|.|:.||::::.::.|||::||||.|.:||..|::||:||.|
  Rat  1074 NLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRLELNDVVYLIRPDP 1138

  Fly  1609 FSAQKTFE--RHNS 1620
            .|.....|  |.||
  Rat  1139 LSYLPNSEPSRKNS 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	41/90 (46%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	71/94 (76%)
Kcnt2	XP_017454291.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346122
Domainoid	1	1.000	507	1.000	Domainoid score	I316
eggNOG	1	0.900	-	-		E1_KOG3193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1188	1.000	Inparanoid score	I183
OMA	1	1.010	-	-		QHG48024
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	1	1.000	-	-		FOG0002662
OrthoInspector	1	1.000	-	-		otm44441
orthoMCL	1	0.900	-	-		OOG6_103731
Panther	1	1.100	-	-	O	PTHR10027
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1773
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810