DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and Kcnt2

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	XP_017175995.1	Gene:	Kcnt2 / 240776	MGIID:	3036273	Length:	1174	Species:	Mus musculus

Alignment Length:	1581	Identity:	646/1581 - (40%)
Similarity:	843/1581 - (53%)	Gaps:	503/1581 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYG 156
            |:||:||:|:|||||||||:|:||||||||||||:.:..||||||:||||||:|:| |:    .|
Mouse    30 DDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLEK-PS----QG 89

  Fly   157 CEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKG 221
            .|                         |..|.||||...||.||:.:|::||.::::|.||.|||
Mouse    90 SE-------------------------WSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKG 129

  Fly   222 NIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSA 286
            |||:|||...||||::..:||.::|..|.|||||:|:||||||||.:||||.||||||:|::|||
Mouse   130 NIWEQILRIPFILEIINAVPFIISIFWPTLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSA 194

  Fly   287 LSQQLTILSATLLCLVFT-------------------------SVCGIQHFQRAGHRHLNLFQST 326
            :..|:.||.:|||||:||                         |:|||||.:|.| :.||||.|.
Mouse   195 MFNQVLILISTLLCLIFTCFTDKTRKHMYHVTLGFTETLTFSQSICGIQHLERIG-KKLNLFDSL 258

  Fly   327 YYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQS 391
            |:.:|||||||:||..|:.|.|:|::|.||||||:|||.||||||:.||||||.||:||.||||:
Mouse   259 YFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQT 323

  Fly   392 EKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGS 456
            |||||:|.::|..|.:|||||||||||.|||:|||:|.|.|:|..:|.:||:|:|:|||||:|||
Mouse   324 EKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGS 388

  Fly   457 CLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHV 521
            .|||.||.||:|:.|||||||::|...|:|::|..||||:|||||||||.|.||||.:||:|.|:
Mouse   389 ALKDQDLLRAKMDNAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHI 453

  Fly   522 KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQ-------EGQQSPEEWHRLYGKCSG 579
            |||:|||||:|||||:||.||.||..|||:|||:||||||       |||||||:|.:.||:|||
Mouse   454 KFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQCVCLCCREGQQSPEQWQKTYGRCSG 518

  Fly   580 NEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKK 644
            ||:|||||.:|.||.|||||||||||||:|:|:||.|||||..:     .:.||||||||:||..
Mouse   519 NEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLVGVRRED-----NKNILLNPGPRYIMNA 578

  Fly   645 DDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTT 709
            .|.|:|::||||||||| .||:|...                ::.|.|.:| ..:..|..:|.
Mouse   579 SDICFYINITKEENSAF-KNQDQQRK----------------SNVSRSFYH-GPSRLPVHSII-- 623

  Fly   710 VQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHL 774
                               ||..|..|:...|:..|                      |:|.|
Mouse   624 -------------------ASMGTVAIDLQDTSCRA----------------------TSGPT-- 645

  Fly   775 QPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPP 839
                                      |.:|||
Mouse   646 --------------------------LALPSE--------------------------------- 651

  Fly   840 PPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLN 904
                               ||..|
Mouse   652 -------------------GGKEL----------------------------------------- 656

  Fly   905 QRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRT 969
                 |||||.||.::..:||.                                         :|
Mouse   657 -----RRPSIAPVLEVADTSSI-----------------------------------------QT 675

  Fly   970 YSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPS 1034
            ..|:...|||.                                                  ..|.
Mouse   676 CDLLSDQSEDE--------------------------------------------------TTPD 690

  Fly  1035 EEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTAT 1099
            ||
Mouse   691 EE--------------------------------------------------------------- 692

  Fly  1100 TTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYL 1164
                                   :||::|               ..||:||.||:||.|||.|:|
Mouse   693 -----------------------TSSNLE---------------YAKGYPPYSPYIGSSPTFCHL 719

  Fly  1165 LKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPI 1229
            |:||.|.|||:|.:.|:|..|.:||.|.::||.||:||:.|.||:||||:||||::|.|..||||
Mouse   720 LQEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPI 784

  Fly  1230 ILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDC 1294
            :|||:..||:.||||:.:||:||:|:||||.||||||.|:|.|.::|||:||.:.|||||.::|.
Mouse   785 VLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADA 849

  Fly  1295 NTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPF 1359
            .|||.||.:|:.|.|:..||||:..:|||||||||.|.|:|.|||:||:|:||||::::||||||
Mouse   850 KTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPF 914

  Fly  1360 AAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKL 1424
            |||.|||.|||||||||:|||||:|:..|||||:|..||||||.||:||:||:|||||.||||||
Mouse   915 AAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTIPGSGFLCSMKITEDDLWIRTYARLYQKL 979

  Fly  1425 CSTTCEIPIGIYRTQD----TSNA----DTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTP 1481
            ||:|.::|||||||:.    ||.:    ..|.:|.| ||.|
Mouse   980 CSSTGDVPIGIYRTESQKLTTSESREIGSQSQISIS-VEEW------------------------ 1019

  Fly  1482 DSTKDSTEMLRGVTYRPPG-------SATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLAD 1539
            :.|||         .:.||       ::|....|..|. .|::|:......| |||..:|...|:
Mouse  1020 EDTKD---------VKDPGHHRSLHRNSTSSDQSDHPL-LRRKSMQWARRLS-RKGPKHSGKTAE 1073

  Fly  1540 ---EARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLI 1601
               :.|.|..::.||.|:|.||::||:.|.|.|:.||::::.::.|||::||||.|.:||..|::
Mouse  1074 KITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRLELNDVV 1138

  Fly  1602 YLVRPSPFSAQKTFE--RHNS 1620
            ||:||.|.|.....|  |.||
Mouse  1139 YLIRPDPLSYLPNSEPSRKNS 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	41/90 (46%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	71/101 (70%)
Kcnt2	XP_017175995.1	Ion_trans	<140..295	CDD:366146	80/155 (52%)
		Ion_trans_2	242..297	CDD:369572	33/55 (60%)
		BK_channel_a	456..558	CDD:367524	71/101 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842660
Domainoid	1	1.000	507	1.000	Domainoid score	I331
eggNOG	1	0.900	-	-		E1_KOG3193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1194	1.000	Inparanoid score	I191
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48024
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002662
OrthoInspector	1	1.000	-	-		otm42378
orthoMCL	1	0.900	-	-		OOG6_103731
Panther	1	1.100	-	-	O	PTHR10027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3407
SonicParanoid	1	1.000	-	-		X1773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790