Protein Alignment SLO2 and slo-2

DIOPT Version :10

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: NP_001257146.1
• Gene: slo-2 / 181332
• WormBaseID: WBGene00004831
• Length: 1143
• Species: Caenorhabditis elegans
• Alignment Length: 1628
• Identity: 549/1628 - (33%)
• Similarity: 762/1628 - (46%)
• Gaps: 518/1628 - (31%)

  Fly    14 MSDDNQ-TCSYSMPSVASPSLNHRLQRNVNFNEDLNDLAGYPPQQLPTAPAVRRFSKSIFQRPRS 77
            ||||.| |....:||:::.|           ::|::|:|....:...|  ..:....|:....:.
 Worm     1 MSDDIQYTGLRRIPSMSNMS-----------DQDVDDIARTDSEAEGT--VYKNSYASLMNELQP 52

  Fly    78 MSVWSDISRSSMRLDERVRVE----YYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVL 138
            .:.:.|..:|..:|.:..|.:    .|..:...|.:||.:||:|...|.|||..::.:|||:|:|
 Worm    53 TTSFDDFKQSITQLTDIFRADPARMQYGEKKNIKHKLQQWFIENPSISARIRSCNVLIKLLTCIL 117

  Fly   139 YIIRVILDKNPTFITCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLL 203
            |.|||:.|           |.....:|..|    |||..:..:..:..:|||:....:|.||.:.
 Worm   118 YCIRVVND-----------ERSYPDDFPFS----EEEAGKQDVTLYKYLLWVDFDFKIWFLQTMF 167

  Fly   204 AMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRS 268
            |.:|:..::::.||.|.|::.:.:::.||:|||:|:.||.::|..|.|..|::|:||||||||.:
 Worm   168 ACISMVYTILVFYLSYSGSVVRLLINIHFLLELITSFPFIISIFIPSLTYLYVPVFLNCWLAKGA 232

  Fly   269 LENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTF 333
            |:.|.|||:|....|.|||.:||.:|.:.|.||:||.:|.|:|.|||..:.::||.|.|:|:|||
 Worm   233 LQAMMNDLNRKSFISSSALFRQLLLLFSVLACLIFTGMCSIEHLQRARGKRIDLFTSFYFVMVTF 297

  Fly   334 STVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVC 398
            |||||||:.||.|.|||.:||:|||||.::|.|.::|..||.||||.|..:||... .|.||||.
 Worm   298 STVGYGDWYPDYWASQLCVVILICVALGLIPKQLDELGQTWSERQKSGTDFSSWNG-VESHVVVT 361

  Fly   399 STTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDL 463
            .|||..:.|.|||.||||||..|...:|||||.|||...||:|::|:|..||.|::||.|:|.||
 Worm   362 ITTLEVEFIRDFLEEFYAHPENQRIQIVLLSPAELDNQTRMLLKIPLWNNRVHYVRGSSLRDEDL 426

  Fly   464 ARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVV 528
            .||.:..::|||||:||:...|.|.||||||||||:|||||||.|||||||.|.|:|::.||.::
 Worm   427 ERANVATSKACFILSARHVNRKVATDEHTILRSWAIKDFAPNVKQYVQIFRAETKMHIEHAEVLI 491

  Fly   529 CEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFF 593
            ||||||||||||||.|||.||.:|||:|||||:|||:|.|.||::||..||||:|.|.:.||:||
 Worm   492 CEDEFKYALLANNCICPGISTFITLLMHTSRGEEGQKSTEPWHKVYGFHSGNEMYQIKVQDSKFF 556

  Fly   594 GEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEEN 658
            .||.||||:..|||:|::||:.|:.|.    |:.....:.||||..||::..||.|||.:|.||
 Worm   557 CEYVGKSFSSTSFHAHKEYGIGLIAVS----PDGDTSRMKLNPGSSHIIQPTDTVYYMGLTNEE- 616

  Fly   659 SAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTS 723
                                |.|....|..|....      ||..:||..
 Worm   617 --------------------SLTDFRKGIRSQQKR------ANVASTIAN--------------- 640

  Fly   724 STLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHP 788
                                     :.:|.|.||.|
 Worm   641 -------------------------IGTVAVDVPRS----------------------------- 651

  Fly   789 PMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGS 853
                 |..|              ::...::..|:....:
 Worm   652 -----DKTE--------------LVGRKKKKRKEKAADE-------------------------- 671

  Fly   854 GGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVP 918
                        .|            |...|.|:                   :.||||||..|
 Worm   672 ------------IH------------LIEVGEHV-------------------QSSRRPSIAMV- 692

  Fly   919 DMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQR 983
                                 ::.:||                              ||.||.|
 Worm   693 ---------------------TEGKID------------------------------SSSDSDQ- 705

  Fly   984 GCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKK 1048
                                                               ||.
 Worm   706 ---------------------------------------------------EEI----------- 708

  Fly  1049 SYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMA 1113
               || :||.                      ...:.:|||.
 Worm   709 ---CD-KCRG----------------------PCIQHKLQRT----------------------- 724

  Fly  1114 AGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQ 1178
                                              :|.|..:||.|.|:|:::||::.||||:|.:
 Worm   725 ----------------------------------YPQVRTYIGTSNTVCHMMKERRSLCCLKLDE 755

  Fly  1179 VCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRP----DV 1239
            .|.|.|..:|.||||:|:.||||||..|:|:||.:|||||::|....|:|||:|||...    :.
 Worm   756 KCAHKSATSAHEYQWRNRPIILAADRTSSGMYNLVIPLRAYYRPVHDLHPIIILLELEEQDSLND 820

  Fly  1240 AFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMF 1304
            |||||:||||.||||.|.:..||.|||||::.||.|||| ||.:..|||.: :|||||:.||.:.
 Worm   821 AFLDAISYFPDVYWMKGKVGNLDCLLRAGVSSAEHVVVV-KETAVMAEEHT-ADCNTIITVQKIH 883

  Fly  1305 KFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASM 1369
            :.||.::.||||:.::||||:||..|:.|:|..|:.||:|::||||:.:|||||||.|.||||:|
 Worm   884 RMFPRLRMITELTHATNMRFVQFNPHNAYSLAQSRFEKKERKRGSHMPFMFRLPFAQGGVFSANM 948

  Fly  1370 LDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIG 1434
            ||.|||||.:|.:|:..|||||||||....|:|||..||.||:|||.||||||||||:..:||||
 Worm   949 LDRLLYQAIIKPFVVDLVRLLLGIDQHSDGGYLTSFVITSDDLWIRNYGRLYQKLCSSVADIPIG 1013

  Fly  1435 IYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPP 1499
            |:||:   ..||..||....|:...|                         ::|||.|
 Worm  1014 IFRTK---KMDTKTVSLDLQEQCKDF-------------------------ENTEMGR------- 1043

  Fly  1500 GSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMES 1564
                                                               ..::.:.|::||..
 Worm  1044 ---------------------------------------------------NKDMYDHVKNRMRL 1057

  Fly  1565 LNL-PTIDYDDVSEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNS----RRKS 1624
            ||: .|....:.|::::.:|||||||:.||:||.||::|::| ||.....|..|.|.    ||..
 Worm  1058 LNIKDTHTLLEGSDEKSQISYVIINPAQDLELESGDIVYVIR-SPIRKDATNARINPRRGLRRSK 1121

  Fly  1625 NIS 1627
            |:|
 Worm  1122 NVS 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	28/43 (65%)
		BK_channel_a	525..619	CDD:460947	60/93 (65%)
slo-2	NP_001257146.1	Ion_trans	112..320	CDD:459842	95/222 (43%)
		Ion_trans_2	<285..327	CDD:462301	28/41 (68%)
		BK_channel_a	490..582	CDD:460947	59/91 (65%)