Protein Alignment SLO2 and Kcnma1

DIOPT Version :10

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_006518654.1
• Gene: Kcnma1 / 16531
• MGIID: 99923
• Length: 1323
• Species: Mus musculus
• Alignment Length: 1473
• Identity: 282/1473 - (19%)
• Similarity: 468/1473 - (31%)
• Gaps: 533/1473 - (36%)

  Fly   214 LTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLN-CWLAKRSLENMFNDLH 277
            |.::.....:|       |.||:.:.:.| .|:  ||   :|:.::|| .||..|.|
Mouse   231 LRFIAANDKLW-------FWLEVNSVVDF-FTV--PP---VFVSVYLNRSWLGLRFL-------- 274

  Fly   278 RAMQKSQ-SALSQQLTIL---------------------SATLLCLVFTSVCGIQHFQRAGHRHL 320
            ||::..| |.:.|.|.||                     :|..:.||..|....::||  .::.|
Mouse   275 RALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQ--NNQAL 337

  Fly   321 NLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYS 385
            ..::..|.::||.|||||||........:|:||..|...|.:..:...::......|:|.|||||
Mouse   338 TYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYS 402

  Fly   386 SHRAQSEKHVVVCS-TTLHADTIMDFLNEFYAHPLLQDFYVVL-----LSP-MELDTTM-RMILQ 442
            :  ....||:|||. .||  :::.:||.:| .|....|..|.:     :|| :||:... |...|
Mouse   403 A--VSGRKHIVVCGHITL--ESVSNFLKDF-LHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQ 462

  Fly   443 VPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVP 507
            |.       :.|||.|...||||.::..|:||.|||.:..||..|.|...|:|..::|::.|.:.
Mouse   463 VE-------FYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIR 520

  Fly   508 QYVQIFRPEHKLHV--------KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQ 564
            ...|:.:..:|.|:        |..:..:|..|.|...:|.:|...|.||::..|.  |.....:
Mouse   521 IITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLF--SMRSFIK 583

  Fly   565 QSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHS-----HRKYGVALVGV--RPA 622
            ...:.|.:.|.:...||:|          .||...:|...||.:     ..|..:.::.:  :.|
Mouse   584 IEEDTWQKYYLEGVSNEMY----------TEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSA 638

  Fly   623 ELPEFYEETILLNPGPRHIMKKDDTC--YYMSITKEENSAFV---VNQNQTSDPTAAAKEGSGTG 682
            .......:.||:||| .|:..::.|.  :..|..||...||.   ...:..:||....|    .|
Mouse   639 NRESRSRKRILINPG-NHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKK----CG 698

  Fly   683 GGGGASSSASHHHTAATA---------NPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINA 738
            ......|..|.:.....|         ...:.::..|:....|:..||..|::        ::|.
Mouse   699 CRRLIYSKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERTFPLSSV--------SVND 755

  Fly   739 TSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFV 803
            .||:..|                                     :....||
Mouse   756 CSTSFRA-------------------------------------FEDEQPP-------------- 769

  Fly   804 PSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHS 868
                                            ||        ||.....:||
Mouse   770 --------------------------------TL--------SPKKKQRNGG------------- 781

  Fly   869 MGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDD 933
                                  ..|:|| .||.::.     ..|.::|             |||.
Mouse   782 ----------------------MRNSPN-TSPKLMR-----HDPLLIP-------------GNDQ 805

  Fly   934 GEEGDESDDEIDDE--MPWRSPSE-----------KIACLGGHFPQSRTYSLIMSSSEDSYQRGC 985
            .:..|.:..:.|..  ..|.:|.|           .:..|.||        :::          |
Mouse   806 IDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGH--------VVV----------C 852

  Fly   986 SFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRV----- 1045
            .|    ...|:|.:.:.....|..|                       |..:..:|:..|
Mouse   853 IF----GDVSSALIGLRNLVMPLRA-----------------------SNFHYHELKHIVFVGSI 890

  Fly  1046 --MKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAA 1108
              :|:.:   ....:.|.:.:       |.|..|:|...|...:..|..|
Mouse   891 EYLKREW---ETLHNFPKVSI-------LPGTPLSRADLRAVNINLCDMC--------------- 930

  Fly  1109 TTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCC 1173
             ..::|.......||              :.|..||:...
Mouse   931 -VILSANQNNIDDTS--------------LQDKECILASL------------------------- 955

  Fly  1174 LQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPD 1238
                         |.|..|:.:...:|.|:  |.|   |..|  ...||....:|:..:| |:|.
Mouse   956 -------------NIKSMQFDDSIGVLQAN--SQG---FTPP--GMDRSSPDNSPVHGML-RQPS 999

  Fly  1239 VAFLDALSYFPLVYWMLG-SIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQN 1302
            :.              .| :|..:.:|.:.|   ...:|.||:|.::...
Mouse  1000 IT--------------TGVNIPIITELAKPG---KLPLVSVNQEKNSGTH--------------- 1032

  Fly  1303 MFKFFPSIKSITELSQSSNMRFMQFRAHD--KYALHLSKMEKREKERGSHISYMFRLPFAAGAVF 1365
                   |..||||...:|::|:.....|  ...|:|::                  |||.|..|
Mouse  1033 -------ILMITELVNDTNVQFLDQDDDDDPDTELYLTQ------------------PFACGTAF 1072

  Fly  1366 SASMLDTLLYQAFVKDYVITFVR------------LLLGIDQAPGSGFLTSMRITKDDMWIRT-- 1416
            :.|:||:|:...:..|.::|.:|            .|:..:.|...|:.|...:...|. .|.
Mouse  1073 AVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR-CRVAQ 1136

  Fly  1417 ----------------YGRLYQKLCSTTCEIPIGIYRTQDTSNADTSH------VSNSPVERWGP 1459
                            ||.|:.|...|...:..||||.:|...:..|.      ::|.|.|
Mouse  1137 LALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYE---- 1197

  Fly  1460 FSAFSRHCVRLRPSYDEETG--------TPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQ 1516
            |.......:.....:|...|        :..|::.|::....|...|..:........|....:|
Mouse  1198 FELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQ 1262

  Fly  1517 RSVNCLG-GCSERK------GSSYSINLADEARDNH-AQQIER 1551
            .:..... |.:|:|      .::|..|:..:....| |.||.:
Mouse  1263 NATRMTRMGQAEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQ 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	16/43 (37%)
		BK_channel_a	525..619	CDD:460947	21/98 (21%)
Kcnma1	XP_006518654.1	Ion_trans	179..396	CDD:459842	47/187 (25%)
		TrkA	343..>523	CDD:440335	64/191 (34%)
		BK_channel_a	546..633	CDD:460947	21/98 (21%)