DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and KCNU1

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	NP_001027006.2	Gene:	KCNU1 / 157855	HGNCID:	18867	Length:	1149	Species:	Homo sapiens

Alignment Length:	1509	Identity:	260/1509 - (17%)
Similarity:	440/1509 - (29%)	Gaps:	633/1509 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 VLQLLLAMVSLTQSLVLTYL----------GYKGN------IWQQILSFHFILELVTT---IPFA 243
            ||.:|:.::|: .||::.::          .|:..      ::....||:|.|..:..   |.|.
Human   104 VLVILVFVLSI-GSLIIYFINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFW 167

  Fly   244 L---TIVH----PPLRNLFIPIFLNC-WLAKRSLENM-------FNDLHRAMQKSQSA-LSQQLT 292
            |   :||.    ||   .||..:|.. ||..|.|..:       ...:.||::.|.|. .|:.|:
Human   168 LEMNSIVDIFTIPP---TFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLS 229

  Fly   293 ILSATLLCLVFTSVCGIQHFQRAG--------HRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQ 349
            |:.:|.    ||:...|...:.:|        .::::.|:|.|.|:.|.||||:||.|......:
Human   230 IILSTW----FTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGR 290

  Fly   350 LYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEF 414
            .:::.....:||:......::...:..::|...||.:  .:.:|.:|||. .:..|::..||..|
Human   291 TFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEA--LKGKKFIVVCG-NITVDSVTAFLRNF 352

  Fly   415 YAHPLLQD------FYVVLLS----PMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMN 469
                 |:|      ..:|.|.    .:||:|..:..|..      ..:|.||.:|..||.|..:.
Human   353 -----LRDKSGEINTEIVFLGETPPSLELETIFKCYLAY------TTFISGSAMKWEDLRRVAVE 406

  Fly   470 EAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHV--------KFAEH 526
            .||||.|:|....:|..|.|...|:|..::|::.......:||.:..:|:::        ...::
Human   407 SAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDN 471

  Fly   527 VVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEE-WHRLYGKCSGNEIYHIVLGDS 590
            ::|..|.|...:|..|..||..|.:|.|...   |..:..|:: |.:.:.....|:|....|.|
Human   472 IICFAELKLGFIAQGCLVPGLCTFLTSLFVE---QNKKVMPKQTWKKHFLNSMKNKILTQRLSD- 532

  Fly   591 RFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEE---TILLNPGPRHIMKKDDTCYYMS 652
                ::.|.||...:.....|..:.|:.:   |....:.:   .::|||.|:..::|:...::::
Human   533 ----DFAGMSFPEVARLCFLKMHLLLIAI---EYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIA 590

  Fly   653 ITKEE--NSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTT 715
            .|.::  .:.|..
Human   591 ETPKDVRRALFYC---------------------------------------------------- 603

  Fly   716 TISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYP 780
                                               |||        :|
Human   604 -----------------------------------SVC--------HD----------------- 608

  Fly   781 QSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMG 845
                               .:|:|.........|.|||
Human   609 -------------------DVFIPELITNCGCKSRSRQ--------------------------- 627

  Fly   846 SPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSR 910
                                                    |:.||
Human   628 ----------------------------------------HITVP-------------------- 632

  Fly   911 RPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMS 975
                                                     |......||.|  ..||.
Human   633 -----------------------------------------SVKRMKKCLKG--ISSRI------ 648

  Fly   976 SSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQ 1040
            |.:||..|        .|||.::::                                       .
Human   649 SGQDSPPR--------VSASTSSIS---------------------------------------N 666

  Fly  1041 LRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPA 1105
            ...|.::.....||:.....||                        ...|...|....|...|
Human   667 FTTRTLQHDVEQDSDQLDSSGM------------------------FHWCKPTSLDKVTLKRT-- 705

  Fly  1106 VAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKP 1170

Human   706 ----------------------------------------------------------------- 705

  Fly  1171 LCCLQLAQVCEHCSYRNAKEYQWQNKTIILA---ADYASNGIYNFIIPLRAHFRSKTSLNPIILL 1232
                            ...:|:::|..:...   |..|..|:.||::||||...::..|.
Human   706 ----------------GKSKYKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELK----- 749

  Fly  1233 LERRPDVAFLDALSY----------FPLVYWMLGSIDCLDDLLRAGI------------------ 1269
                 |:.|:.:|.|          ||.:|.:.|......||..|.|
Human   750 -----DIVFIGSLDYLQREWRFLWNFPQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSN 809

  Fly  1270 -TLAESVVVVNKELSNSAEEDSLSDCNTIVAVQ--------NMFKFFPSIKSITELSQSSNMRFM 1325
             ||.::..::......|.:.||.||.:..|:.:        |.......:..:|||...||:.|:
Human   810 QTLVDTEAIMATLTIGSLQIDSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKNPSNIHFI 874

  Fly  1326 QFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLL 1390
            :         .|..:|...:|...|:|    ..|:.|.|||.|.||:||..||...:|:..:::|
Human   875 E---------QLGGLEGSLQETNLHLS----TAFSTGTVFSGSFLDSLLATAFYNYHVLELLQML 926

  Fly  1391 LGIDQAPGSGFLTS---MRITKDDMWIRTYG--RLYQKLCSTTCEIPIGIYRTQDTSNADTSHVS 1450
            :       :|.::|   ..:.||    :.||  .....|.|......:|:....:|..:|.:..:
Human   927 V-------TGGVSSQLEQHLDKD----KVYGVADSCTSLLSGRNRCKLGLLSLHETILSDVNPRN 980

  Fly  1451 NSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQR 1515
            .......|....|...||.|....|||...|::.       |.|..||       |:.|:..|
Human   981 TFGQLFCGSLDLFGILCVGLYRIIDEEELNPENK-------RFVITRP-------ANEFKLLP-- 1029

  Fly  1516 QRSVNCL----GGCSERK-----GSSYSI-NLADEARDNHAQQIERAEIANLVRSRMESLNLPTI 1570
            ...|.|.    ..|.:|.     ..||.| |.|.:..:.|:.    ......:.|..|:|..|..
Human  1030 SDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSD----TNCPPTIDSVTETLYSPVY 1090

  Fly  1571 DYDDVSEKRNHLSY 1584
            .|   ..:.|.||:
Human  1091 SY---QPRTNSLSF 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	19/73 (26%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	22/95 (23%)
KCNU1	NP_001027006.2	Ion_trans	141..323	CDD:278921	45/188 (24%)
		Ion_trans_2	230..317	CDD:285168	20/90 (22%)
		Selectivity for potassium	276..279		2/2 (100%)
		BK_channel_a	469..557	CDD:281490	22/95 (23%)
		Segment S7	480..500		6/19 (32%)
		Segment S8	537..557		4/19 (21%)
		Segment S9	711..731		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..854		6/25 (24%)
		Segment S10	895..915		11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1149
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D858812at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850