DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and kcnma1

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	XP_031761893.1	Gene:	kcnma1 / 100491898	XenbaseID:	XB-GENE-922336	Length:	1334	Species:	Xenopus tropicalis

Alignment Length:	1556	Identity:	295/1556 - (18%)
Similarity:	475/1556 - (30%)	Gaps:	621/1556 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLN-CWLAKRSLENMFNDLH 277
            |.::.....:|       |.||:.:.:.| .|:  ||   :|:.::|| .||..|.|
Frog   203 LRFIAANDKLW-------FWLEVNSVVDF-FTV--PP---VFVSVYLNRSWLGLRFL-------- 246

  Fly   278 RAMQKSQ-SALSQQLTILSAT------LLCLVFTS----VCGIQHF-QRAG--------HRHLNL 322
            ||::..| |.:.|.|.||..:      .||.:|.|    ..|..|. :.:|        .:.|:.
Frog   247 RALRLIQFSEILQFLNILKTSNSIKLVNLCSIFISTWLTAAGFIHLVENSGDPWRNFENSQDLSY 311

  Fly   323 FQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSH 387
            ::..|.::||.|||||||........:|:||..|...|.:..:...::......|:|.|||||:
Frog   312 WECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSA- 375

  Fly   388 RAQSEKHVVVCS-TTLHADTIMDFLNEFYAHPLLQDFYVVL-----LSP-MELDTTM-RMILQVP 444
             ....||:|||. .||  :::.:||.:| .|....|..|.:     :|| :||:... |...||.
Frog   376 -VSGRKHIVVCGHITL--ESVSNFLKDF-LHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVE 436

  Fly   445 IWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQY 509
                   :.|||.|...||||.::..|:||.|||.:..||..|.|...|:|..::|::.|.:...
Frog   437 -------FYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRII 494

  Fly   510 VQIFRPEHKLHV--------KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQS 566
            .|:.:..:|.|:        |..:..:|..|.|...:|.:|...|.||::..|.  |.....:..
Frog   495 TQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLF--SMRSFIKIE 557

  Fly   567 PEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHS-----HRKYGVALVGVRPAELPE 626
            .:.|.:.|.:...||:|          .||...:|...||.:     ..|..:.::.:      |
Frog   558 EDTWQKYYLEGVSNEMY----------TEYLSSAFVGLSFPAVCELCFVKLKLLMIAI------E 606

  Fly   627 FYEE--------TILLNPGPRHIMKKDDTC--YYMSITKEENSAFV---VNQNQTSDPTAAAKEG 678
            |..|        .|::||| .|:..|:.|.  :..|..||...||.   ...:..:||....|
Frog   607 FKSEKGESRSRKRIIINPG-NHVKIKEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKK-- 668

  Fly   679 SGTGGGGGASSSASHHHTAATANPT------TTITTTVQATTTTISTTFTSSTLLSASTTTATIN 737
                              .|...||      :....::...|...|.:..||.|.:..
Frog   669 ------------------CACKRPTREENRLSIHRLSIHPQTAKASYSVASSKLCTEQ------- 708

  Fly   738 ATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLF 802
                    ..|||.|                                          :....|||
Frog   709 --------QEPVPLV------------------------------------------NNRKGSLF 723

  Fly   803 VPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAH 867
            :|.::....:                             |.:||.                |:.|
Frog   724 LPCDSSLLHL-----------------------------QLLGSS----------------GTEH 743

  Fly   868 SMGTSLSITPATLTTTGN---HLDVPFA-------NNPNLLSPDVLNQRRGSRRPSILPVPDMFT 922
            .  ||:.:..| |:..|.   |.:.|..       ..|:.|||. ..||.|..|.|....|:|..
Frog   744 R--TSIKLQRA-LSLPGKYRYHPNQPVLIQKQFEDEQPSALSPK-KKQRNGGMRQSPNSSPNMMR 804

  Fly   923 SSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSF 987
            .....:.||          |:||:                          :.|||...|
Frog   805 HDPLLMTGN----------DQIDN--------------------------MDSSSVKRY------ 827

  Fly   988 CSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAM----PSEEYLPQLRRRVMKK 1048
                                                    ||..|    |::|
Frog   828 ----------------------------------------DSTGMFHWCPAKE------------ 840

  Fly  1049 SYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMA 1113
                                        |.::...|.:                    ||.|.::
Frog   841 ----------------------------LDKVLLTRSE--------------------AAMTVLS 857

  Fly  1114 AGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQ 1178
            .......|...:|
Frog   858 GHVVVCIFGDMTS---------------------------------------------------- 870

  Fly  1179 VCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRA---HFRSKTSLNPIILLLERRPDVA 1240
                                      |..|:.|.::||||   |:.   .|..|:
Frog   871 --------------------------ALIGVRNLVMPLRASNFHYH---ELKHIV---------- 896

  Fly  1241 FLDALSY----------FPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCN 1295
            |:.:|.|          ||.|..:.|:.....||....|.|.:..|:::.. .|:.::.||.|..
Frog   897 FVGSLDYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSAN-QNNIDDTSLQDKE 960

  Fly  1296 TIVAVQNM--FKFFPSIKSITELSQSSNMRFMQFRAHDKYALH-------------------LSK 1339
            .|:|..|:  .:|..||..:...||......|:..:.|...:|                   |:|
Frog   961 CILASLNIKSMQFDDSIGLLQANSQGFTPPGMERSSPDNSPVHGVARQASITTGANIPIITELAK 1025

  Fly  1340 MEK--------REKERGSHISYMFRL-------------------------PFAAGAVFSASMLD 1371
            ..|        :||..|:||..:..|                         |||.|..|:.|:||
Frog  1026 PGKLLPLISFSQEKNSGTHIPIITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLD 1090

  Fly  1372 TLLYQAFVKDYVITFVR------------LLLGIDQAPGSGFLTSMRITKDDMWIRT-------- 1416
            :|:...:..|.::|.:|            .|:..:.|...|:.|...:...|. .|.
Frog  1091 SLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR-CRVAQLALYDG 1154

  Fly  1417 ----------YGRLYQKLCSTTCEIPIGIYRTQDTSNADTSH------VSNSPVERWGPFS---- 1461
                      ||.||.|...|...:..||||.:|...:..|.      ::|.|.|    |.
Frog  1155 PFADLGDGGCYGDLYCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYE----FELVPT 1215

  Fly  1462 -------AFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSV 1519
                   .|..:..:.|.|....:.:..|:...:..:..:.:....:......: |....:|:
Frog  1216 DLIFCLMQFDHNASQSRASLSHSSHSSHSSSKKSSSVTSILHTASANRQNRVKA-RDSRDKQK-- 1277

  Fly  1520 NCLGGCSERKGSSYSINLADEARDNHAQQIE----RAEIANLVRSRMESLNL--PTIDYDD 1574
                  :.|.|.:......||..:.:.:.|:    ...:||.:.....:.:|  |..:.:|
Frog  1278 ------TNRMGQAEKKWYTDETENTYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVED 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	23/84 (27%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	21/99 (21%)
kcnma1	XP_031761893.1	Ion_trans	151..368	CDD:395416	48/185 (26%)
		PRK10537	<315..475	CDD:236711	59/171 (35%)
		BK_channel_a	510..605	CDD:397526	22/106 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000