DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLO2 and kcnt1

DIOPT Version :9

Sequence 1:	NP_001097259.2	Gene:	SLO2 / 5740325	FlyBaseID:	FBgn0261698	Length:	1878	Species:	Drosophila melanogaster
Sequence 2:	NP_001163984.3	Gene:	kcnt1 / 100316919	XenbaseID:	XB-GENE-22063991	Length:	1215	Species:	Xenopus tropicalis

Alignment Length:	1609	Identity:	662/1609 - (41%)
Similarity:	864/1609 - (53%)	Gaps:	465/1609 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EDLNDLAGYPPQQLP---TAPAVRRFSKSIFQRPRSMSVWSDISRSSMRLDERVRVEYYVNENTF 106
            ||||.::...|.::.   |:.|.:|.....|...||.|              :|:||:|||||||
Frog    26 EDLNGVSPLLPARIMGSLTSDAGQRNHTEEFSLDRSYS--------------QVQVEFYVNENTF 76

  Fly   107 KERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKL 171
            ||||:|:||||||||||||:.:..||||||.|||:||:||..            .:.|......:
Frog    77 KERLKLFFIKNQRSSLRIRVFNFSLKLLSCFLYIVRVLLDDL------------RQDECCPKQNV 129

  Fly   172 TEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILEL 236
            |..:.||   |.|||||||.|.|.|||:|:::|.:|.:::::|.||.||||||:||....||||:
Frog   130 TVHKHQE---IRWDAILWVERATPLWVIQVIVAAISFSETMLLIYLSYKGNIWEQIFRISFILEM 191

  Fly   237 VTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCL 301
            :.|:||.:||..|||||||||:||||||||..||||.||||||:|:.|||:..|:.||..|||||
Frog   192 INTVPFIITIFWPPLRNLFIPVFLNCWLAKCVLENMINDLHRAIQRIQSAMFNQVIILICTLLCL 256

  Fly   302 VFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQ 366
            |||.:|||||.:|||. :|:||:|.|:.:||||||||||..|.||||||.:||||||||:|||.|
Frog   257 VFTGMCGIQHLERAGD-NLSLFKSFYFCIVTFSTVGYGDVTPQIWPSQLLVVIMICVALVVLPLQ 320

  Fly   367 FEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPM 431
            ||:|.:.||||||.||:||.||||:|||||:|.::|..|.:|||||||||||.|||:|||:|.|.
Frog   321 FEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPT 385

  Fly   432 ELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRS 496
            |:|..:|.:||:|:|:|||||:|||.|||.||.||:|::|||||||::||..|:||||..||||:
Frog   386 EMDIQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDDAEACFILSSRNEVDRTAADHQTILRA 450

  Fly   497 WAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQ 561
            |||||||||.|.||||.:||:|.|||||:|||||:|||||:||.||.||..|||:|||:||||||
Frog   451 WAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEEFKYAMLALNCVCPATSTLITLLVHTSRGQ 515

  Fly   562 EGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPE 626
            |||||||:|.|:||:|||||:|||.||||:||.||||||||||:||:|:||||.|:||:..:
Frog   516 EGQQSPEQWQRMYGRCSGNEVYHIRLGDSKFFMEYEGKSFTYAAFHAHKKYGVCLIGVKRED--- 577

  Fly   627 FYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSA 691
              .::|||||||||||...|||:|::|||||||||:..|.:       .::..|.|...|.|...
Frog   578 --NKSILLNPGPRHIMAASDTCFYINITKEENSAFIFKQEE-------KQKRKGRGLYDGPSRLP 633

  Fly   692 SHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRV 756
            .|.                                :.||..|..::..:|...   |:.|
Frog   634 VHS--------------------------------IIASMGTVAMDLQNTECR---PINS----- 658

  Fly   757 PHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLK 821
                                                      :.|.:||||.|
Frog   659 ------------------------------------------SKLALPSENGT------------ 669

  Fly   822 DTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNH 886

Frog   670 ----------------------------------------------------------------- 669

  Fly   887 LDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWR 951
                                 |:|||||.||.::..:|:.
Frog   670 ---------------------GTRRPSIAPVLEIADTSTV------------------------- 688

  Fly   952 SPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYP 1016
                 :.|           .|:...|||..
Frog   689 -----LPC-----------DLLSDQSEDEL----------------------------------- 702

  Fly  1017 SDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLA 1081
                    |.:|..:.|..||
Frog   703 --------TQSDDESFPILEY-------------------------------------------- 715

  Fly  1082 ARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVK 1146
                                                                           ||
Frog   716 ---------------------------------------------------------------VK 717

  Fly  1147 GFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYN 1211
            |:||.||:||.|||||:||..|...|||:|.:.|:|.|:.:||.|.::||.||::|:.|.||:||
Frog   718 GYPPNSPYIGSSPTLCHLLPSKAAFCCLRLDKGCKHNSFEDAKAYGFKNKLIIVSAETAGNGLYN 782

  Fly  1212 FIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVV 1276
            ||:||||::||:..||||:|||:..||..||:|:..||:||:|:|:||.||:||:.||..|:::|
Frog   783 FIVPLRAYYRSRKELNPIVLLLDNPPDNHFLEAICCFPMVYFMVGTIDNLDNLLQCGIIYADNLV 847

  Fly  1277 VVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKME 1341
            ||:||.:.|||||.::|..|||.||.||:.|||:...|||:..||||||||||.|.|:|.|||:|
Frog   848 VVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLE 912

  Fly  1342 KREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMR 1406
            |:|:|.||::::|||||||||.|||.|||||||||:|||||:||..|||||:|..||||:|.:|:
Frog   913 KKERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMK 977

  Fly  1407 ITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLR 1471
            ||:||:||||||||:|||||::.|||:||||||       ||.          |.....|.:|.:
Frog   978 ITEDDLWIRTYGRLFQKLCSSSAEIPVGIYRTQ-------SHT----------FPTSEPHDIRTQ 1025

  Fly  1472 PSYDEETGTPDSTKDSTEMLRGV-TYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSI 1535
            ..........:.|||..|...|. |.|   ::|....|..|. .|::|:......| |||:..:.
Frog  1026 SQISINVEDCEDTKDVKEYWSGKNTQR---NSTSSDQSEHPL-LRRKSMQWARRLS-RKGNKQAN 1085

  Fly  1536 NLAD---EARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDV---------------------S 1576
            ..|:   :.|.|..::.||.|::.||::||:.|.|||:.|:||                     :
Frog  1086 KTAEWISQQRLNLYRRSERQELSELVKNRMKHLGLPTMGYEDVANVTASDVMNRVNLGYLQDEMN 1150

  Fly  1577 EKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNSRRKSN 1625
            :.:|.||||:|||..|.:||..|::||:|..|. |....|.| ||:.||
Frog  1151 DHQNTLSYVLINPPPDTRLELNDIVYLIRSDPL-AHVANESH-SRKSSN 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	46/65 (71%)
SLO2	NP_001097259.2	BK_channel_a	524..619	CDD:281490	72/94 (77%)
kcnt1	NP_001163984.3	Ion_trans	<187..317	CDD:366146	89/130 (68%)
		Ion_trans_2	253..319	CDD:369572	47/66 (71%)
		BK_channel_a	478..573	CDD:367524	72/94 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11055
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010