Protein Alignment SLO2 and kcnt1a

DIOPT Version :9

• Sequence 1: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Sequence 2: XP_009293403.1
• Gene: kcnt1a / 100004419
• ZFINID: ZDB-GENE-091231-1
• Length: 1173
• Species: Danio rerio
• Alignment Length: 1588
• Identity: 631/1588 - (39%)
• Similarity: 846/1588 - (53%)
• Gaps: 489/1588 - (30%)

  Fly    73 QRPRSMSVWSDISRSSMRLD-------ERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLF 130
            ::..::..|.:.:..:.|||       :||.||:||:||||||||:|:|||||||||||||.:..
Zfish     2 EQKNAVPSWVNPALVNWRLDSFGSDAGQRVHVEFYVDENTFKERLKLFFIKNQRSSLRIRIFNFC 66

  Fly   131 LKLLSCVLYIIRVILDKNPTFI--TCYGCEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRP 193
            ||||:||||||||:.| ||..:  ||..|...|.                   |||:.|.||:|.
Zfish    67 LKLLTCVLYIIRVMTD-NPAQLRHTCVNCSSQND-------------------INWELIFWVDRK 111

  Fly   194 TVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPI 258
            ..:|.:|:::|.:|..::::||||.||||:|:||....|:||::.|:||.:||..|||||||||:
Zfish   112 VPVWAIQVIVASISFMEAMLLTYLSYKGNLWEQIFQVSFLLEMLNTVPFIITIFWPPLRNLFIPV 176

  Fly   259 FLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLF 323
            ||||||||.:||:|.||||||:|::.||:..|:.||..||||||||..|||||.:|||.:.|:||
Zfish   177 FLNCWLAKCALESMINDLHRAIQRTHSAMFNQVLILICTLLCLVFTGTCGIQHLERAGKKSLSLF 241

  Fly   324 QSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHR 388
            .:.|:.:|||||||:||..|.||||||.:|:||||||:|||.|||:|.:.||||||.||:||.||
Zfish   242 NALYFCIVTFSTVGFGDVTPQIWPSQLLVVVMICVALVVLPLQFEELIYLWMERQKSGGNYSRHR 306

  Fly   389 AQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYI 453
            ||:|:|||:|.:||..|.:|||||||||||..||:|||:|.|.|:|..:|.|||:|:|:|||||:
Zfish   307 AQTERHVVLCVSTLKIDLLMDFLNEFYAHPHTQDYYVVILCPCEVDVQVRRILQIPLWSQRVIYL 371

  Fly   454 QGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHK 518
            |||.||:.||.||:|::|||||||::||.||:.|||..||||:|||||||||.|.||||.:||:|
Zfish   372 QGSALKNQDLLRAKMDDAEACFILSSRNEADRMAADHQTILRAWAVKDFAPNCPLYVQILKPENK 436

  Fly   519 LHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIY 583
            .|||||:|||||:|||||:||.||.||..|||:|||:|||||||||||||:|.|:||:|||||:|
Zfish   437 FHVKFADHVVCEEEFKYAMLALNCLCPATSTLITLLVHTSRGQEGQQSPEQWQRMYGRCSGNEVY 501

  Fly   584 HIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTC 648
            ||.||||.||.||..||||||:||:|:||||.::||:..:     .::|||||||||||...|||
Zfish   502 HIRLGDSMFFREYNSKSFTYAAFHAHKKYGVCMIGVKRED-----NKSILLNPGPRHIMSASDTC 561

  Fly   649 YYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGASSSASHHHTAATANPTTTITTTVQAT 713
            ||::|||||||||:..|          :|..|.|          ..|.....:|:.....::.|:
Zfish   562 YYINITKEENSAFIFRQ----------EEDQGKG----------RSHCDFLNSPSGLPVHSIIAS 606

  Fly   714 TTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYP 778
            ..|::..|.:::
Zfish   607 MGTVAMDFQNTS----------------------------------------------------- 618

  Fly   779 YPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQT 843
                                     |:|:           .||               |.||
Zfish   619 -------------------------PTES-----------GLK---------------LAPP--- 629

  Fly   844 MGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRG 908
                                                   |.|.|                    |
Zfish   630 ---------------------------------------TENEL--------------------G 635

  Fly   909 SRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLI 973
            ||||||.||.::..|:|.                              :.|           .|:
Zfish   636 SRRPSIAPVLEIADSTSL------------------------------LPC-----------DLL 659

  Fly   974 MSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYL 1038
            ...||                                       |.||.|  |.|
Zfish   660 SDQSE---------------------------------------DEAGHS--NED---------- 673

  Fly  1039 PQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTT 1103
                                                                             
Zfish   674 ----------------------------------------------------------------- 673

  Fly  1104 PAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEK 1168
              :.||                              |:   |||:||.||:||.|||||:||.:|
Zfish   674 --ITAT------------------------------DF---VKGYPPNSPYIGSSPTLCHLLPQK 703

  Fly  1169 KPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLL 1233
            .|.|||:|.|.|||.|:.:||.|.::||.||::|:.|.||:||||:||||::|.:..||||:|||
Zfish   704 APFCCLRLDQSCEHVSFEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRPRRELNPIVLLL 768

  Fly  1234 ERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIV 1298
            :..||..||:|:|.||:||:|.|:||.||.||:.|:..|:::|||:||.:.|||||.::|..|||
Zfish   769 DNLPDDHFLEAISCFPMVYYMGGTIDNLDSLLQCGVLYADNLVVVDKESTMSAEEDYMADAKTIV 833

  Fly  1299 AVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLSKMEK--------------REKERGS 1349
            .||.||:.|||:..||||:..||||||||||.|.|:|.|||:||              :|:::||
Zfish   834 NVQTMFRLFPSLSIITELTHPSNMRFMQFRAKDCYSLALSKLEKFCNWNIAKCVFDQQKERDKGS 898

  Fly  1350 HISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLTSMRITKDDMWI 1414
            ::::|||||||||.|||.|||||||||.|||||:|...|||||:|..||||:|.:|.|.:.|:||
Zfish   899 NLAFMFRLPFAAGRVFSISMLDTLLYQCFVKDYMIPIARLLLGLDTTPGSGYLCAMHICEADLWI 963

  Fly  1415 RTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCVRLRPSYDEETG 1479
            ||||||:||.||::.|||||||||:          |::|.|            ::...|.|....
Zfish   964 RTYGRLFQKFCSSSSEIPIGIYRTE----------SHAPPE------------LQSSVSIDGLND 1006

  Fly  1480 TPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERKGSSYSINLADEARDN 1544
            |.:..::|..:.|        |::....|..|. .|::|::.     .|:.|..|:..:|.:..:
Zfish  1007 TREKGEESKILTR--------SSSSSDQSDHPL-LRKKSMHW-----TRRLSRRSVKRSDSSLSS 1057

  Fly  1545 HAQQI------ERAEIANLVRSRMESLNLPTIDY---------------------DDVSEKRNHL 1582
            ..|::      ||.|:..|||:||:.|.|.|..|                     |::::::|.:
Zfish  1058 IQQRLGVLRRSEREELTELVRNRMQHLGLHTGGYKDVTNLTASDVMNRVNLGYLQDELNDQQNSI 1122

  Fly  1583 SYVIINPSCDLKLEEGDLIYLVRPSPFS 1610
            |||:|||:.|..|:..|:::|:||.|.:
Zfish  1123 SYVLINPAPDTLLQLNDVVFLIRPDPLA 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLO2	NP_001097259.2	Ion_trans_2	297..363	CDD:285168	43/65 (66%)
		BK_channel_a	524..619	CDD:281490	69/94 (73%)
kcnt1a	XP_009293403.1	Ion_trans_2	<239..289	CDD:285168	32/49 (65%)
		BK_channel_a	442..537	CDD:281490	69/94 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587082
Domainoid	1	1.000	482	1.000	Domainoid score	I394
eggNOG	1	0.900	-	-		E1_KOG3193
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11055
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I222
OMA	1	1.010	-	-		QHG48024
OrthoDB	1	1.010	-	-		D143826at33208
OrthoFinder	1	1.000	-	-		FOG0002662
OrthoInspector	1	1.000	-	-		otm24770
orthoMCL	1	0.900	-	-		OOG6_103731
Panther	1	1.100	-	-	O	PTHR10027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1773
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770