Protein Alignment smal and DDR1

DIOPT Version :10

• Sequence 1: NP_723165.2
• Gene: smal / 5740323
• FlyBaseID: FBgn0085409
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_054186331.1
• Gene: DDR1 / 780
• HGNCID: 2730
• Length: 984
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 197/716 - (27%)
• Similarity: 297/716 - (41%)
• Gaps: 191/716 - (26%)

  Fly    53 LWTLVIASGCLMLNAPTTMAFDIATCNVPLGMESLLITDAQITASSAHDMAFVGPQHARLKTDND 117
            |..|::|||    :|.....||.|.|...|||:...|.|:.|:|||:...: ...:|:||::.:.
Human    28 LLLLLVASG----DADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDS-TAARHSRLESSDG 87

  Fly   118 GGAWCPKHMVSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYTEAYVLEYWRPGFDKWQRWK 182
            .|||||...|....:|||||||.:.|::..:.||||:..|.|:|::.:|.|.|.|.| .:|..||
Human    88 DGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDG-RRWMGWK 151

  Fly   183 NIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLRAEIVGCPWEEGIVSYSIPK 247
            :..|:|::.||.:....|...|.|.:.|..:|.||......:||||.|:.||.|.:|::||:.|.
Human   152 DRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPV 216

  Fly   248 G--VQRGMEVDLSDKTYDGNEQGDRYVDGLGQLVDGQKGKDNFRTDIH-GFGKGYEWIGWRNDTP 309
            |  :.....|.|:|.||||:..|.....|||||.||..|.|:||.... ....||:::||.|.:
Human   217 GQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHS- 280

  Fly   310 GLLGKPVEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFSIG-GRYFSGEPVQFSYMPDT 373
             .....||:.||||.:|.|.|:.:|.|||.|...::....:..|..| ...:.|||::.:...:.
Human   281 -FSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNL 344

  Fly   374 IMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISFI------SVPAMG-------------- 418
            ....||.|::.|..||.::|:....||..|::.||||||      |.||:|
Human   345 GDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPP 409

  Fly   419 --NFTD-EQEQRSNSPSQAQDVHDETNGSEYQANRNKPNGVGGSAGGLGEGVAAAGGDIVGNNKY 480
              ||:. |.|.|...|                                   ||.|.|
Human   410 PTNFSSLELEPRGQQP-----------------------------------VAKAEG-------- 431

  Fly   481 NNGPQLIAPRPIDQEPNDANFIGVVIVVLTTIIILLVAIILF------IVSRTKRARGSNVLDAF 539
                   :|..|        .||.::.:: .:::|::|::|:      ::|:.:|    .||:.
Human   432 -------SPTAI--------LIGCLVAII-LLLLLIIALMLWRLHWRRLLSKAER----RVLEE- 475

  Fly   540 QYSFNPNTLGGNV--------------DKHRPNGNSIKANVDDNDSIGKNSLYHEPFNVNMYTCG 590
            :.:.:.:..|..:              .:.||.||                   .|.:.   .|.
Human   476 ELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGN-------------------PPHSA---PCV 518

  Fly   591 VNGYAAV--NDLQCNMTPDYTDVPEG------GYAVP-----HMQDYMPSSKMGGGAPGGGGYVN 642
            .||.|.:  |.....:...|...|.|      .:|.|     :..|||...|  .|||
Human   519 PNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEK--PGAP------- 574

  Fly   643 VRRTPPPPLSSIFPR-------------------PPTVPP------PPMEKYYATTAIFKPLKGP 682
              ..||||.:|: |.                   .|.:||      ||...:..:...||...|.
Human   575 --LLPPPPQNSV-PHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGE 636

  Fly   683 G 683
            |
Human   637 G 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smal	NP_723165.2	FA58C	81..233	CDD:238014	57/151 (38%)
DDR1	XP_054186331.1	FA58C	78..202	CDD:238014	48/124 (39%)
		PTKc_DDR1	622..931	CDD:133227	4/16 (25%)