DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smal and ddr2l

DIOPT Version :9

Sequence 1:	NP_723165.2	Gene:	smal / 5740323	FlyBaseID:	FBgn0085409	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001072499.1	Gene:	ddr2l / 779954	XenbaseID:	XB-GENE-5884186	Length:	879	Species:	Xenopus tropicalis

Alignment Length:	617	Identity:	191/617 - (30%)
Similarity:	284/617 - (46%)	Gaps:	126/617 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 CLWTLVIASG---CLMLNAPTTMAFDIATCNVPLGMESLLITDAQITASSAHDMAFVGPQHARLK 113
            |.:.|.:.||   |.::.         |:|...|||....|.|..|.|||.. ....|||:|||:
Frog     4 CFFLLALLSGRAKCAVIP---------ASCRYALGMHDRTIRDEDIIASSQW-YESTGPQYARLQ 58

  Fly   114 TDNDGGAWCPKHMVSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYTEAYVLEYWRPGFDKW 178
            .:...|||||..::.....:|||:||.:.|.||.|.||||:.:..|:|:..||.::|.|.| .:|
Frog    59 REEGDGAWCPAGLLQPEDVQYLQIDLHELHFITLIGTQGRHARATGKEFARAYRVDYSRNG-GRW 122

  Fly   179 QRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLRAEIVGCPWEEGIVSY 243
            ..|::.||::::.||::.|..|...|:|.|.|..||:.|..:...|||:|.|:.||.|.:|:.||
Frog   123 LSWRDHQGQQVMRGNVDEYEVVLADLRPPIIARYIRVIPVTKVPMTVCMRVELYGCKWSDGLTSY 187

  Fly   244 SIPKG---VQRGMEVD-LSDKTYDGNEQGDRYVDGLGQLVDGQKGKDNFRTDI-HGFGKGYEWIG 303
            |:|:|   :..|..:. |:|.||||..:..|...|||||.||..|.|:|...: :....||::||
Frog   188 SVPEGETYIAPGQPIAFLNDSTYDGYLEKRRQFGGLGQLTDGIHGLDDFTQSLQYRVWPGYDYIG 252

  Fly   304 WRNDTPGLLGKP---VEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFS--IGGRYFSGE 363
            ||||:     .|   ||:.|.||..||||.:.:|.||:|:|.|::|..|:..|.  :.|.: ..|
Frog   253 WRNDS-----APRGYVEVEFHFDRPRNFSLMKVHCNNLFSKGVKIFQKAECLFKPRLEGEW-EAE 311

  Fly   364 PVQFSYMPDTIMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISF-----ISVPAMGNFTDE 423
            ||....:.|.....||.|||.|..|||..:....|||..|:|.|||||     |:||.:|.
Frog   312 PVVVLMVVDDKNPSARFVTIPLRQRVGSAILCRFYFADAWMMFSEISFESDMGIAVPTLGT---- 372

  Fly   424 QEQRSNSPSQAQDVHDE-TNGSEYQANRNKPNGVGGSAGGLGEGVAAAGGDIVGNNKYNNGPQLI 487
             :..:::|:|..:|... .|.:|.:.....|..:.
Frog   373 -QSPTSAPAQTTEVPVALQNSTERKLETTFPFTIS------------------------------ 406

  Fly   488 APRPIDQEPNDANFIGVVIVVLTTIIILLVAIILFIV------SRTKRARGSNVLD---AFQYSF 543
              ||:...|....  .|:|..|..||:|||.:|:.|:      .|.::| ...:|:   ..:.||
Frog   407 --RPVVNPPESRT--SVLIGCLVAIILLLVLVIVLILWKQYVQKRLEKA-PRRILEEDATVRLSF 466

  Fly   544 NPNTLGGNVDKHRPNGNSIKANVDDNDSIGKNSLYHEPFNVNMYTCGVNGY-------------- 594
            ...|:          |||.:..:..:     |..|...|.:::      .|
Frog   467 YSYTI----------GNSQQTQIHQS-----NPTYERIFPLDL------DYQQPTKPLRKLPELS 510

  Fly   595 AAVNDLQCN---MTPDYT-DVPEGGY--AVPH 620
            .:..|..|:   ..||.| ..|..|:  :|||
Frog   511 QSAEDSACSGDYAEPDLTKSTPHQGFQNSVPH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smal	NP_723165.2	FA58C	78..234	CDD:214572	61/155 (39%)
smal	NP_723165.2	FA58C	81..233	CDD:238014	60/151 (40%)
ddr2l	NP_001072499.1	FA58C	26..177	CDD:238014	60/152 (39%)
ddr2l	NP_001072499.1	PTKc_DDR_like	579..873	CDD:133228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm9464
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070