DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smal and DDR2

DIOPT Version :9

Sequence 1:	NP_723165.2	Gene:	smal / 5740323	FlyBaseID:	FBgn0085409	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001014796.1	Gene:	DDR2 / 4921	HGNCID:	2731	Length:	855	Species:	Homo sapiens

Alignment Length:	749	Identity:	206/749 - (27%)
Similarity:	293/749 - (39%)	Gaps:	229/749 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PRWTLCLWTL--VIASGCLMLNAPTTMAFDIATCNVPLGMESLLITDAQITASSAHDMAFVGPQH 109
            ||..|.|:.|  :::|....:|.        |.|..||||....|.|..|||||....: ...::
Human     5 PRMLLVLFLLLPILSSAKAQVNP--------AICRYPLGMSGGQIPDEDITASSQWSES-TAAKY 60

  Fly   110 ARLKTDNDGGAWCPKHMVS-NALKEYLQVDLLQTHVITAIRTQGRYGKGQGQEYTEAYVLEYWRP 173
            .||.::...|||||:..|. :.|||:||:||...|.||.:.||||:..|.|.|:...|.:.|.|.
Human    61 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRD 125

  Fly   174 GFDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRTVCLRAEIVGCPWEE 238
            | .:|..|:|..||::|.||.|.|......|:|.|.|..:|..|...:...||:|.|:.||.|.:
Human   126 G-TRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLD 189

  Fly   239 GIVSYSIPKGVQ----RGMEVDLSDKTYDGNEQGDRYVDGLGQLVDGQKGKDNFRTDIHGF--GK 297
            |:|||:.|.|.|    .|..:.|:|..||| ..|....:|||||.||..|.|:| |..|.:  ..
Human   190 GLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLDDF-TQTHEYHVWP 252

  Fly   298 GYEWIGWRND--TPGLLGKPVEIVFEFDTVRNFSAIVLHTNNMFTKDVQVFVHAKVFFSIGGRYF 360
            ||:::||||:  |.|.    :||:||||.:|||:.:.:|.||||.|.|::|...:.:|......:
Human   253 GYDYVGWRNESATNGY----IEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEW 313

  Fly   361 SGEPVQFSYMPDTIMDHARDVTIKLHHRVGKYLKINLYFAVKWIMLSEISFISVPAMGNFTDEQE 425
            ....:.|..:.|.:...||.||:.||||:...:|...:||..|:|.|||:|.|..||
Human   314 EPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAM-------- 370

  Fly   426 QRSNSPSQAQDVHDETNGSEYQANRNKPNGVGGSAGGLGEGVAAAGGDIVGNNKYNNGPQL---- 486
                                                                  |||...|
Human   371 ------------------------------------------------------YNNSEALPTSP 381

  Fly   487 IAPRPIDQ--EPNDANFIGVVIVVLTTIIILLVAIILFIVSR------TKRARGSNVLDAFQYSF 543
            :||...|.  :.:|:| ..::|..|..||.:|:|||:.|:.|      .::|....:.|....|.
Human   382 MAPTTYDPMLKVDDSN-TRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSL 445

  Fly   544 N-PNTLGGNVDKHRPNGNSIKANVDDNDSIGKNSLYHEPFNVNMYTCGVNGYAAVNDLQCNMTPD 607
            : |:      |....|.|...:..:.    |.||.|...|
Human   446 SLPS------DSSMFNNNRSSSPSEQ----GSNSTYDRIF------------------------- 475

  Fly   608 YTDVPEGGYAVPHMQDYMPSSKMGGGAPGGGGYVNVRRTPPPPLSSIFPRPPTVPPPPMEKYYAT 672
                       |...||...|::            :|:.|.                     :|
Human   476 -----------PLRPDYQEPSRL------------IRKLPE---------------------FA- 495

  Fly   673 TAIFKPLKGPGSERSGCSSNTNTVSSGGGKSSHSHSSHCSTGGPDHSGIYDDGIGTMNSKATAPM 737
                     ||.|.||||.....|...|.:           |.|.:              |.|.:
Human   496 ---------PGEEESGCSGVVKPVQPSGPE-----------GVPHY--------------AEADI 526

  Fly   738 IN--PYSSGNSSSAAA----------AAAAEFQR 759
            :|  ..:.||:.|..|          .|..||.|
Human   527 VNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smal	NP_723165.2	FA58C	78..234	CDD:214572	61/156 (39%)
smal	NP_723165.2	FA58C	81..233	CDD:238014	60/152 (39%)
DDR2	NP_001014796.1	FA58C	32..184	CDD:238014	60/153 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..471		5/22 (23%)
		PTKc_DDR2	557..851	CDD:270677	3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7173
eggNOG	1	0.900	-	-		E1_KOG1094
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1223
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm8570
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830