DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment uex and cnnm2a

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001138257.1	Gene:	cnnm2a / 555472	ZFINID:	ZDB-GENE-050208-36	Length:	811	Species:	Danio rerio

Alignment Length:	804	Identity:	356/804 - (44%)
Similarity:	485/804 - (60%)	Gaps:	83/804 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TSVDTSNKLLLQKANDFNLSQNLSSSRTRRTI-----ANSFRIVGIRLE--DETVETKNGIPTVL 78
            |:|.|||...|.:|....:...:.||...::|     :....|:|:|||  ||......|...|.
Zfish     6 TAVPTSNMAALNRAGSLTVIFLIVSSCLIKSIDGKDPSEETVIIGLRLEDTDEVSFMDRGFLRVS 70

  Fly    79 VDKEQQFRVFGSGLEENT--AITFTNEKNDYGGPCLKPA-TDLFTPIEVSSNGFSALYSVKF--- 137
            .....:.||:|..:...|  .:.||..:::.....|.|. .....|..:.|:....|.:::.
Zfish    71 ERSRVRLRVYGQNINNETWSKLAFTEHRSNAPAESLSPGDAPASHPCGIRSSDIIILPTMEVNRK 135

  Fly   138 PSFINEFFI--CAKTAEKTTNHSKAATTTP-----------LEHQG-NSDFLKIKTFEPLIPVWL 188
            .|.|.|..:  ..||.:..|.:...|..||           :.|:| ::..:.::..:.|:|.||
Zfish   136 TSGIIELEVKPLRKTEKSKTYYLCTAIGTPGAQDSWSEHTWVYHEGHDTKVIVVEEKKFLLPFWL 200

  Fly   189 AIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQGNYLLCSILLG 253
            .:|.|...|..|.:|||||||||::|..||:|::|.||||||.||..|.|||.||||||||:|||
Zfish   201 QVIFIAMLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKHYAKAIEPVRSQGNYLLCSLLLG 265

  Fly   254 NVLVNSTFTILLDGLT-SGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVTKTVMAITA 317
            |||||:|.|||||.:. |||.||:.||:.||:||||.|||:|||||||:||.||.:||..|.:|.
Zfish   266 NVLVNTTLTILLDDIAGSGLIAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMILTF 330

  Fly   318 PLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGALELRKKTVADVMTH 382
            |.|||||::||.:||:|||.|||||:|.|::|||:..|||.|.|:|||.||||||.|||.||||.
Zfish   331 PASYPVSKLLDHVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTP 395

  Fly   383 INDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDTDDNTPLKTLCEF 447
            :.|.||:|.||:|||.|:||||.|||:|||||:|:|.:||.||::|||||||.||.|||||:.:|
Zfish   396 LRDCFMISGDAILDFATMSEIMESGYTRIPVYEGERCHIVDLLFVKDLAFVDPDDCTPLKTITKF 460

  Fly   448 YQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELIQAEI 512
            |.:|:||||.|..||.|..:||:|. .|:|.|.||||||:||||||.:|:|||||||||:|::||
Zfish   461 YSHPLHFVFNDTKLDAMLEEFKKGK-SHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEI 524

  Fly   513 VDETDVFVDNRTKTR-RNRYKKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDVISE 576
            :||||::.||:||.: .:|.||.|||||........|:|||||.|||.::|:|.|::|....:||
Zfish   525 LDETDLYTDNKTKKKIAHREKKQDFSAFKPTENELRVKISPQLLLATLRFLATEVESFSATQMSE 589

  Fly   577 LILRRLL-NQDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESGPFT 640
            .||.||| :.:|...:|...|.|.....|:|.:.|.||:|:|||:|:|||..|||.:.||:|.|:
Zfish   590 KILLRLLKHPNVIQELKYDDKDKKMSEHYLFHRNKPVDYFILILQGKVEVEAGKEGMKFEAGAFS 654

  Fly   641 YFGTQALVPN----------VVIDSPTQMGSLQ--------------SLNMDSKIR--------- 672
            |:|..:|..:          ||..:.:..||.:              |||...::.
Zfish   655 YYGVLSLTSSPVPLSLSRTFVVSRAESLAGSPENKSPPRPFGLNHSDSLNRSDRMEAVTPTLGSS 719

  Fly   673 --------QSFVPDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSG---------TFSSETF 720
                    |.:||||||||:||::||.:.|..|..|..|:.::|:.:|.         || :|..
Zfish   720 NNQLNSFLQVYVPDYSVRAVSDLLYIKVTRQQYQNALMASRMDKTPQSTDSEFTKIELTF-TEHQ 783

  Fly   721 DDEVERLLHSITEN-EKPSCFAQN 743
            |..:|.....:|.| .||:..|.|
Zfish   784 DGPLEESATLLTTNSHKPNHTAHN 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	111/173 (64%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	79/121 (65%)
		CAP_ED	<604..>650	CDD:294041	23/45 (51%)
cnnm2a	NP_001138257.1	DUF21	200..374	CDD:279876	111/173 (64%)
cnnm2a	NP_001138257.1	CBS_pair_CorC_HlyC_assoc	398..518	CDD:239963	79/120 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590140
Domainoid	1	1.000	222	1.000	Domainoid score	I2520
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	581	1.000	Inparanoid score	I984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm25855
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760