DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment uex and CNNM2

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_060119.3	Gene:	CNNM2 / 54805	HGNCID:	103	Length:	875	Species:	Homo sapiens

Alignment Length:	811	Identity:	340/811 - (41%)
Similarity:	468/811 - (57%)	Gaps:	130/811 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IVGIRLED--ETVETKNGIPTVLVDKEQQFRVFGSGLEENT--AITFTNE--------KNDYGGP 110
            |:|:||||  :....:.|...|......:.||:|..:...|  .|.||..        :...|||
Human    74 IIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGP 138

  Fly   111 C------------LKPATDLFTPIEVSSNGFSALYSVKFPSF-----INEFFICAKTAEKTTNHS 158
            .            ::.:..:..|..:.:...|.:..::....     ...:::|...:.......
Human   139 APPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAG 203

  Fly   159 KA-----------------------ATTTPLEHQGNSDFLKI---KTFEPLIPVWLAIIIIVTCL 197
            .:                       |.||.:.|.|....:.:   |.|  |:|.||.:|.|...|
Human   204 GSGSTGGAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKF--LLPFWLQVIFISLLL 266

  Fly   198 GFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQGNYLLCSILLGNVLVNSTFT 262
            ..|.:|||||||||::|..||:|::|.||||||.||.:|.|||.||||||||:||||||||:|.|
Human   267 CLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLT 331

  Fly   263 ILLDGLT-SGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVTKTVMAITAPLSYPVSRI 326
            ||||.:. |||.||:.||:.||:||||.|||:|||||||:||.||.:||..|.:|.|.|||||::
Human   332 ILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKL 396

  Fly   327 LDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGALELRKKTVADVMTHINDAFMLSL 391
            ||.:||:|||.|||||:|.|::|||:..|||.|.|:|||.||||||.|||.||||.:.|.||::.
Human   397 LDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITG 461

  Fly   392 DALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDTDDNTPLKTLCEFYQNPVHFVF 456
            :|:|||.|:||||.|||:||||::|:|.|||.||::|||||||.||.|||||:.:||.:|:||||
Human   462 EAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVF 526

  Fly   457 EDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELIQAEIVDETDVFVD 521
            .|..||.|..:||:|. .|:|.|.||||||:||||||.:|:|||||||||:|::||:||||::.|
Human   527 NDTKLDAMLEEFKKGK-SHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTD 590

  Fly   522 NRTKTR-RNRYKKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDVISELILRRLL-N 584
            ||||.: .:|.:|.|||||.:......|:|||||.||..::|:|.|:||....:||.||.||| :
Human   591 NRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKH 655

  Fly   585 QDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESGPFTYFGTQALVP 649
            .:|...:|...|:|..|..|::.:.|.||:|||||:|:|||..|||.:.||:..|:|:|..||..
Human   656 PNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTA 720

  Fly   650 NVV--------------------------------------------ID--SPTQMGSLQSLNMD 668
            :.|                                            ||  :||...|...||
Human   721 SPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGSSNNQLN-- 783

  Fly   669 SKIRQSFVPDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSGTFSSETFDDEVERLLHSITE 733
            |.:.|.::|||||||:||:.::.|.|..|..|..|:.::|:.:|.       |.|..::..::||
Human   784 SSLLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSS-------DSENTKIELTLTE 841

  Fly   734 -------------NEKPSCFAQNQSTRRLSN 751
                         ||: :|...:::...|.|
Human   842 LHDGLPDETANLLNEQ-NCVTHSKANHSLHN 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	111/173 (64%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	77/121 (64%)
		CAP_ED	<604..>650	CDD:294041	23/45 (51%)
CNNM2	NP_060119.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..151		4/29 (14%)
		CorC_HlyC	256..>586	CDD:332085	213/330 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..763		0/20 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155082
Domainoid	1	1.000	218	1.000	Domainoid score	I2660
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9761
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1067
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm40918
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.760