DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment uex and Cnnm4

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_017451999.1	Gene:	Cnnm4 / 363216	RGDID:	1305571	Length:	793	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	327/770 - (42%)
Similarity:	452/770 - (58%)	Gaps:	104/770 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IVGIRL---EDETVETKNGIPTVLVDKEQQFRVFGSGLEE--NTAITFT---------NEKNDYG 108
            |:|:||   ........:||..|........|::|..|.|  :..|:||         |..|
  Rat    44 ILGMRLASCNKSCGMNPDGIIFVSEGSTVNLRLYGHRLGEISSNLISFTEVDDAETVHNSTN--- 105

  Fly   109 GPCLKPATDLFTP--IEVSSNGFSALYSVKFPSFINE------FFICAKTAE-----KTTNHSKA 160
              ||:...||...  :.||....|.:. |....|:..      :.:|.:|..     |.|:  |.
  Rat   106 --CLELTKDLVVQRLVNVSRGNTSGML-VVITKFLRRSENMKLYALCTRTRADGPWLKWTD--KD 165

  Fly   161 ATTTPLEHQGNSDFLKIKTFEPLIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTG 225
            :....:|..|.           .:|:||.|::::..|..|.:|||||||||::|..||:|::|.|
  Rat   166 SLLFMVEEHGR-----------FLPLWLHILLVLVLLVLSGIFSGLNLGLMALDPMELRIVQNCG 219

  Fly   226 TEKEKKYASKIAPVRDQGNYLLCSILLGNVLVNSTFTILLDGLT-SGLFAVIFSTLAIVLFGEIT 289
            ||||::||.||.|:|.:|||||||:||||||||::.|||||.|. ||:.||..||:.||:||||.
  Rat   220 TEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGIMAVASSTIGIVIFGEIL 284

  Fly   290 PQAVCSRHGLAIGAKTILVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDV 354
            |||:|||||||:||.||::||..|.:|.|||:|:|::||.:||:||..|||||:|.|:::||...
  Rat   285 PQALCSRHGLAVGANTIVLTKIFMLLTFPLSFPISKLLDFVLGQEIRTVYNREKLMEMLKVTEPY 349

  Fly   355 NDLDKNEVNIISGALELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRK 419
            |||.|.|:|:|.||||||.|||.|:||.::|.||:..||:|||.|:||||.|||:||||::.::.
  Rat   350 NDLVKEELNMIQGALELRTKTVEDIMTQLHDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQS 414

  Fly   420 NIVTLLYIKDLAFVDTDDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNN 484
            |||.:||:|||||||.||.|||||:..||.:||||||.|..||.|..:||:|. .|:|.|.:|||
  Rat   415 NIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGK-SHLAIVQKVNN 478

  Fly   485 EGDGDPFYETVGLVTLEDVIEELIQAEIVDETDVFVDNRTKTRRNRYKKADFSAFAERREVQTVR 549
            ||:||||||.:|||||||||||:|::||:||:|.:.||||:.|.:...|.|||||.:......|:
  Rat   479 EGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDTYTDNRTRKRVSMKNKRDFSAFKDADNELKVK 543

  Fly   550 ISPQLTLATFQYLSTAVDAFKKDVISELILRRLLN-QDVFHNIKTKGKSKDDPSLYIFTQGKAVD 613
            |||||.||..::|:|.|..|...::||.||.|||. .||...::....:|.....|::|:.|..|
  Rat   544 ISPQLLLAAHRFLATEVPQFSPSLMSEKILLRLLKYPDVIQELRFDEHNKHCTRHYLYTRNKPAD 608

  Fly   614 FFVLILEGRVEVTIGKEALMFESGPFTYFGTQAL---VPNVVIDSPTQMGSLQSL---------- 665
            .|:|||:|:|||..|||.:.||:|.|:|:||.||   .|...:.:....|.|.||
  Rat   609 CFILILQGKVEVEAGKENMKFETGAFSYYGTMALSLAPPAPPVQAGCSTGKLNSLLSRLADRSPA 673

  Fly   666 ----------------NMD-------------SKIRQSFVPDYSVRAISDVIYITIKRVLYLTAK 701
                            |.|             |.|...:|.|:||||::|:.||.:.|..|....
  Rat   674 HPTPLSRSASLSYPDRNTDMTPSSLAGSNQFGSCILGQYVSDFSVRALTDLQYIKVTRQQYQNGL 738

  Fly   702 KATLLEKSRKSGTFSSETFDDEVERLLHSITEN--EKPSCFAQNQSTRRLSNRSI 754
            .|:.::.|.:.      |.|.     ..:.|||  |:|.....:::|..|:.|::
  Rat   739 LASRMDNSPQL------TLDG-----CATCTENLSERPELPVVDETTTLLNERNL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	104/173 (60%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	77/121 (64%)
		CAP_ED	<604..>650	CDD:294041	24/48 (50%)
Cnnm4	XP_017451999.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348959
Domainoid	1	1.000	218	1.000	Domainoid score	I2570
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1030
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm45055
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	LDO	PTHR12064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760