DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment uex and Cnnm3

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001100371.2	Gene:	Cnnm3 / 301345	RGDID:	1307926	Length:	711	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	218/573 - (38%)
Similarity:	318/573 - (55%)	Gaps:	48/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 LGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQGNYLLCSILLGNVLVNSTF 261
            |..:|:..||.|..:::...|:::||.:|:|.|:..|.::.|.|......|.::||...|..:..
  Rat   149 LALAAVARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWAGCALGALLLLASLAQAAL 213

  Fly   262 TILLDGLTS--GLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVTKTVMAITAPLSYPVS 324
            .:||.|...  .:.||:.....:.|.||:.|.||..|..||:..:.:.:::..:.:|.|::.||.
  Rat   214 AVLLYGAVGQRAVPAVLGCAGLVFLVGEVLPAAVSGRWALALAPRALGLSRLAVLLTLPVALPVG 278

  Fly   325 RILDKLLGEEIGNVYNRERLKELVRVTND-VNDLDKNEVNIISGALELRKKTVADVMTHINDAFM 388
            ::|:  |....|.:  |||:.||.|...| .:||.|.         .||.:||.||:|.:.|.||
  Rat   279 QLLE--LAARPGRL--RERVLELARGGGDPYSDLSKG---------VLRYRTVEDVLTPLEDCFM 330

  Fly   389 LSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDTDDNTPLKTLCEFYQNPVH 453
            |....:|||..::.||.||::||||::.:|.|||.:||:|||||||.:|.|||.|:..||.:|:|
  Rat   331 LDSGTVLDFSVLASIMQSGHTRIPVFEEERSNIVDMLYLKDLAFVDPEDCTPLSTITRFYNHPLH 395

  Fly   454 FVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELIQAEIVDETDV 518
            |||.|..||.:..:||.|. .|:|.|.:|||||:||||||.:|||||||||||:|::||:||::.
  Rat   396 FVFNDTKLDAVLEEFKRGK-SHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIRSEILDESED 459

  Fly   519 FVDNRTKTRRNRY-----KKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDVISELI 578
            :.|.:.|.:....     :|.:||.|....:...|:|||||.|||.::||..||.|....|||.:
  Rat   460 YSDTKVKKKAVTLGAPLKRKEEFSLFKVSDDEYKVKISPQLLLATQRFLSREVDVFSPLRISEKV 524

  Fly   579 LRRLL-NQDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESGPFTYF 642
            |..|| :..|...:|....::.....|::.:.:.||:|:|||:|||||.||||.|.||:|.|||:
  Rat   525 LLHLLKHPSVNQEVKFDESNRLATHHYLYQRSQPVDYFILILQGRVEVEIGKEGLKFENGAFTYY 589

  Fly   643 GTQAL-VPNVVIDSPTQ-----MGSLQSLNMDSKIRQSFVPDYSVRAISDVIYITIKRVLYLTAK 701
            |..|| .|:....||..     ...||....||....::.|||:|||:||:..|.:.|:.||.|.
  Rat   590 GVSALTAPSSAHQSPVSSRQLIRHDLQPEPADSTRSCTYCPDYTVRALSDLQLIKVTRLQYLNAL 654

  Fly   702 KATLLE-----------------KSRKSGTFSSETFDDEVERLLHSITENEKP 737
            .||..:                 ::|..|..|.||......|  .||...|.|
  Rat   655 LATRAQSLPPSPENAELQAIPGSQTRLLGDKSRETAGPSSSR--RSIPVEESP 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	49/166 (30%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	69/121 (57%)
		CAP_ED	<604..>650	CDD:294041	26/46 (57%)
Cnnm3	NP_001100371.2	CBS_pair_CorC_HlyC_assoc	327..447	CDD:239963	69/120 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348960
Domainoid	1	1.000	145	1.000	Domainoid score	I4454
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710