DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment uex and Cnnm2

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001011942.1	Gene:	Cnnm2 / 294014	RGDID:	1308162	Length:	875	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	341/812 - (41%)
Similarity:	468/812 - (57%)	Gaps:	127/812 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IVGIRLED--ETVETKNGIPTVLVDKEQQFRVFGSGLEENT--AITFTNE--------KNDYGGP 110
            |:|:||||  :....:.|...|......:.||:|..:...|  .|.||..        :...|||
  Rat    74 IIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHTPGERGLGGP 138

  Fly   111 C------------LKPATDLFTPIEVSSNGFSALYSVKFPSF-----INEFFICAK--------- 149
            .            ::.:..:..|..:.:...|.:..::....     ...:::|..
  Rat   139 APPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAG 203

  Fly   150 ---TAEKTTNHSKA-----------ATTTPLEHQGNSDFLKI---KTFEPLIPVWLAIIIIVTCL 197
               :|..|......           |.||.:.|.|....:.:   |.|  |:|.||.:|.|...|
  Rat   204 GSGSASGTVGGKGGAGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKF--LLPFWLQVIFISLLL 266

  Fly   198 GFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQGNYLLCSILLGNVLVNSTFT 262
            ..|.:|||||||||::|..||:|::|.||||||.||.:|.|||.||||||||:||||||||:|.|
  Rat   267 CLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLT 331

  Fly   263 ILLDGLT-SGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVTKTVMAITAPLSYPVSRI 326
            ||||.:. |||.||:.||:.||:||||.|||:|||||||:||.||.:||..|.:|.|.|||||::
  Rat   332 ILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKL 396

  Fly   327 LDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGALELRKKTVADVMTHINDAFMLSL 391
            ||.:||:|||.|||||:|.|::|||:..|||.|.|:|||.||||||.|||.||||.:.|.||::.
  Rat   397 LDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITG 461

  Fly   392 DALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDTDDNTPLKTLCEFYQNPVHFVF 456
            :|:|||.|:||||.|||:||||::|:|.|||.||::|||||||.||.|||||:.:||.:|:||||
  Rat   462 EAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVF 526

  Fly   457 EDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELIQAEIVDETDVFVD 521
            .|..||.|..:||:|. .|:|.|.||||||:||||||.:|:|||||||||:|::||:||||::.|
  Rat   527 NDTKLDAMLEEFKKGK-SHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTD 590

  Fly   522 NRTKTR-RNRYKKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDVISELILRRLL-N 584
            ||||.: .:|.:|.|||||.:......|:|||||.||..::|:|.|:||....:||.||.||| :
  Rat   591 NRTKKKVAHRERKQDFSAFKQTDSETKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKH 655

  Fly   585 QDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESGPFTYFGTQALVP 649
            .:|...:|...|:|..|..|::.:.|.||:|||||:|:|||..|||.:.||:..|:|:|..||..
  Rat   656 PNVIQELKYDEKNKKAPECYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTA 720

  Fly   650 NVV--------------------------------------------IDSPTQMGSLQSLNMDSK 670
            :.|                                            ||:.|......:..:.|.
  Rat   721 SPVPLSLSRTFVVSRTEVLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLSSS 785

  Fly   671 IRQSFVPDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSG-----------TFSSETFDDEV 724
            ..|.::|||||||:||:.::.|.|..|..|..|:.::|:.:|.           |...:...||.
  Rat   786 FLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTEMHDGLPDET 850

  Fly   725 ERLLHSITENEKPSCFAQNQSTRRLSNRSINS 756
            ..||     ||: :|.:.|:     :|.|::|
  Rat   851 ANLL-----NEQ-NCVSHNK-----ANHSLHS 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	111/173 (64%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	77/121 (64%)
		CAP_ED	<604..>650	CDD:294041	23/45 (51%)
Cnnm2	NP_001011942.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..148		3/25 (12%)
		DUF21	257..431	CDD:279876	111/173 (64%)
		CBS_pair_CorC_HlyC_assoc	470..575	CDD:239963	69/105 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..763		0/21 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348957
Domainoid	1	1.000	218	1.000	Domainoid score	I2570
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9761
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1030
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm45055
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760