DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment uex and CNNM1

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001332816.1	Gene:	CNNM1 / 26507	HGNCID:	102	Length:	972	Species:	Homo sapiens

Alignment Length:	762	Identity:	283/762 - (37%)
Similarity:	403/762 - (52%)	Gaps:	123/762 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 FFICAKTAEKTTNHSKAA----TTTPLEHQGNSDFLKIKTFEPLIPVWLAIIIIVTCLGFSALFS 204
            |.:||.......:|..|.    ...|..:....|.|.        |.||..:..:..|..|||||
Human   184 FSLCAWDGRAWHHHGAAGGFLLRVRPRLYGPGGDLLP--------PAWLRALGALLLLALSALFS 240

  Fly   205 GLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQGNYLLCSILLGNVLVNSTFTILL---- 265
            ||.|.|:|:|..||::|||:|:..|::.|.::..||.:|.:|||::|||....|:.....|
Human   241 GLRLSLLSLDPVELRVLRNSGSAAEQEQARRVQAVRGRGTHLLCTLLLGQAGANAALAGWLYTSL 305

  Fly   266 -------------DGLTSGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVTKTVMAITA 317
                         :|:.......:..|.|:.|..||.|.:|||||||||.:.::.:|:.:||...
Human   306 PPGFGGTGEDYSEEGIHFPWLPALVCTGAVFLGAEICPYSVCSRHGLAIASHSVCLTRLLMAAAF 370

  Fly   318 PLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGALELRKKTVADVMTH 382
            |:.||:.|:||..|.:||...|.||:|.|.:|..:..:||.|.|:|||.||||||.|.|.:|:|.
Human   371 PVCYPLGRLLDWALRQEISTFYTREKLLETLRAADPYSDLVKEELNIIQGALELRTKVVEEVLTP 435

  Fly   383 INDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGD-RKNIVTLLYIKDLAFVDTDDNTPLKTLCE 446
            :.|.|||..||:|||.|||||:.|||:|||||:|| |.|||.:|::|||||||.||.|||.|:..
Human   436 LGDCFMLRSDAVLDFATVSEILRSGYTRIPVYEGDQRHNIVDILFVKDLAFVDPDDCTPLLTVTR 500

  Fly   447 FYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELIQAE 511
            ||..|:|.||.|..||.:..:||:|. .|:|.|.||||||:||||||.:|:|||||:|||:|::|
Human   501 FYNRPLHCVFNDTRLDTVLEEFKKGK-SHLAIVQRVNNEGEGDPFYEVMGIVTLEDIIEEIIKSE 564

  Fly   512 IVDETDVFVDNRTKTR---RNRYKKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDV 573
            |:||||::.|||.|.|   |.| |:.|||.|........|:|||||.|||.::::|.|:.||...
Human   565 ILDETDLYTDNRKKQRVPQRER-KRHDFSLFKLSDTEMRVKISPQLLLATHRFMATEVEPFKSLY 628

  Fly   574 ISELILRRLL-NQDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESG 637
            :||.||.||| :.:|...:|...|:|..|..|::.:.:.||:|||:|:|:|||.:|||.|.||:|
Human   629 LSEKILLRLLKHPNVIQELKFDEKNKKAPEHYLYQRNRPVDYFVLLLQGKVEVEVGKEGLRFENG 693

  Fly   638 PFTYFGTQALVPNVVID---------------------------------------SPTQMGSLQ 663
            .|||:|..|::.....|                                       ||::...|.
Human   694 AFTYYGVPAIMTTACSDNDVRKVGSLAGSSVFLPVSVSRTFAVSRGDSLAGSPVNRSPSRCSGLN 758

  Fly   664 SLNMDSKIRQSF---------------VPDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSG 713
            .....::.|..|               :|||||..:|||.::.|.|..|..|..|..::.|.:|.
Human   759 RSESPNRERSDFGGSNTQLYSSSNNLYMPDYSVHILSDVQFVKITRQQYQNALTACHMDSSPQSP 823

  Fly   714 TFSSETFDDEVERLLHSITENEKPSCFAQNQSTRRLSNRSINSSPTNMN---RSP-DFVYNSVDE 774
            ...:.|..|..:    :.|....|.....:.:...|:||  ||.|.:.:   ||| :.||..::|
Human   824 DMEAFTDGDSTK----APTTRGTPQTPKDDPAITLLNNR--NSLPCSRSDGLRSPSEVVYLRMEE 882

  Fly   775 AIQDDTKLKNIKHADNVTTSISLVAAELEDL--HSGEQDT-TAASMP 818
                                ::....|:.|.  ||.:|.| :.|::|
Human   883 --------------------LAFTQEEMTDFEEHSTQQLTLSPAAVP 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	69/189 (37%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	76/122 (62%)
		CAP_ED	<604..>650	CDD:294041	23/45 (51%)
CNNM1	NP_001332816.1	DUF21	237..414	CDD:279876	66/176 (38%)
		CBS	429..553	CDD:223591	74/124 (60%)
		CBS_pair_CorC_HlyC_assoc	438..553	CDD:239963	71/115 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155083
Domainoid	1	1.000	147	1.000	Domainoid score	I4513
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1067
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm40918
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760